scholarly journals Risk factors for histological progression of non‐alcoholic steatohepatitis analyzed from repeated biopsy cases

2020 ◽  
Vol 35 (8) ◽  
pp. 1412-1419
Author(s):  
Kana Daijo ◽  
Takashi Nakahara ◽  
Yuki Inagaki ◽  
Maiko Nanba ◽  
Yuno Nishida ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alcoholic Steatohepatitis ◽  
Histological Progression

Incidence and risk factors for non-alcoholic steatohepatitis in females treated with tamoxifen for breast cancer

2011 ◽  
Vol 12 (1) ◽  
pp. 34-36 ◽  
Author(s):  
Mohsen Akhondi-Meybodi ◽  
Mohammad-Reza Mortazavy-zadah ◽  
Zahra Hashemian ◽  
Mahdiah Moaiedi
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Alcoholic Steatohepatitis

P1034 : Characterisation of the prevalence and risk factors for biopsy-proven non-alcoholic steatohepatitis among patients with gallstones: A prospective study

2015 ◽  
Vol 62 ◽  
pp. S735-S736
Author(s):  
C. Garcia-Monzon ◽  
J. Vargas-Castrillon ◽  
J.L Porrero ◽  
M.T. Alonso ◽  
O. Bonachia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prospective Study ◽  
Alcoholic Steatohepatitis ◽  
A Prospective Study

scholarly journals Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver

Diagnostics ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 129
Author(s):  
Toshihiro Niikura ◽  
Kento Imajo ◽  
Anna Ozaki ◽  
Takashi Kobayashi ◽  
Michihiro Iwaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery ◽  
Fatty Liver ◽  
Smoking Status ◽  
Calcium Score ◽  
Agatston Score ◽  
Coronary Artery Lesions ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Steatohepatitis ◽  
Independent Risk Factors

Non-alcoholic fatty liver disease (NAFLD) is associated with a higher risk of atherosclerotic disease. However, the relationships between the severity of coronary atherosclerosis and pathologic findings in patients with NAFLD remain unknown. We aimed to characterize the coronary artery lesions in patients with NAFLD using coronary computed tomography angiography (CCTA). Overall, 101 patients with liver biopsy-proven NAFLD who had chest pain or electrocardiographic abnormalities underwent CCTA. Coronary artery lesions, including coronary artery stenosis (CAS), calcium score (CACS, Agatston score), and coronary artery non-calcified plaque were assessed using multi-slice CT. Multivariate analysis showed that age, smoking status, prevalence of dyslipidemia (DLP) and non-alcoholic steatohepatitis (NASH), and stage of fibrosis were independent risk factors for CAS. Age, and the prevalence of DM and DLP, were independent risk factors for CACS, and the prevalence of NASH tended to be an independent risk factor. In addition, the prevalence of DLP and NASH were independent risk factors for non-calcified plaques. Coronary artery lesions are more common in patients with NASH than in those with non-alcoholic fatty liver, suggesting a higher risk in patients with NASH. Therefore, patients with NASH should be closely followed, with particular vigilance for coronary artery diseases.

scholarly journals Metabolic syndrome and risk factors for non-alcoholic fatty liver disease

2012 ◽  
Vol 49 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Mônica Rodrigues de Araújo Souza ◽  
Margareth de Fátima Formiga de Melo Diniz ◽  
José Eymard Moraes de Medeiros-Filho ◽  
Maria Salete Trigueiro de Araújo
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Experimental Studies ◽  
Final Analysis ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Steatohepatitis ◽  
Alcoholic Fatty Liver Disease

CONTEXT: Non-alcoholic fatty liver disease (NAFLD), hepatic manifestation of metabolic syndrome, has been considered the most common liver disease nowadays, which is also the most frequent cause of elevated transaminases and cryptogenic cirrhosis. The greatest input of fatty acids into the liver and consequent increased beta-oxidation contribute to the formation of free radicals, release of inflammatory cytokines and varying degrees of hepatocytic aggression, whose histological expression may vary from steatosis (HS) to non-alcoholic steatohepatitis (NASH). The differentiation of these forms is required by the potential risk of progression to cirrhosis and development of hepatocellular carcinoma. OBJECTIVE: To review the literature about the major risk factors for NAFLD in the context of metabolic syndrome, focusing on underlying mechanisms and prevention. METHOD: PubMed, MEDLINE and SciELO data basis analysis was performed to identify studies describing the link between risk factors for metabolic syndrome and NAFLD. A combination of descriptors was used, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, metabolic syndrome and risk factors. At the end, 96 clinical and experimental studies, cohorts, meta-analysis and systematic reviews of great impact and scientific relevance to the topic, were selected. RESULTS: The final analysis of all these data, pointed out the central obesity, type 2 diabetes, dyslipidemia and hypertension as the best risk factors related to NAFLD. However, other factors were highlighted, such as gender differences, ethnicity, genetic factors and the role of innate immunity system. How these additional factors may be involved in the installation, progression and disease prognosis is discussed. CONCLUSION: Risk factors for NAFLD in the context of metabolic syndrome expands the prospects to 1) recognize patients with metabolic syndrome at high risk for NAFLD, 2) elucidate pathways common to other co-morbidities, 3) determine risk factors associated with a worse prognosis, 4) develop therapeutic strategies with goal of reducing risk factors, 5) apply acquired knowledge in public health policies focusing on preventive strategies.

scholarly journals Incidence and risk factors for non-alcoholic steatohepatitis: prospective study of 5408 women enrolled in Italian tamoxifen chemoprevention trial

BMJ ◽  
2005 ◽  
Vol 330 (7497) ◽  
pp. 932 ◽  
Author(s):  
Savino Bruno ◽  
Patrick Maisonneuve ◽  
Paola Castellana ◽  
Nicole Rotmensz ◽  
Sonia Rossi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Prospective Study ◽  
Alcoholic Steatohepatitis ◽  
Chemoprevention Trial

scholarly journals Non-Alcoholic Steatohepatitis as a Risk Factor for Intrahepatic Cholangiocarcinoma and Its Prognostic Role

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3182
Author(s):  
Stefania De Lorenzo ◽  
Francesco Tovoli ◽  
Alessandro Mazzotta ◽  
Francesco Vasuri ◽  
Julien Edeline ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Confidence Interval ◽  
Intrahepatic Cholangiocarcinoma ◽  
Cox Regression ◽  
Relevant Information ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Steatohepatitis ◽  
Group B ◽  
Healthy Liver

Non-alcoholic fatty liver disease (NAFLD) and its most aggressive form, non-alcoholic steatohepatitis (NASH), are causing a rise in the prevalence of hepatocellular carcinoma. Data about NAFLD/NASH and intrahepatic cholangiocarcinoma (iCCA) are few and contradictory, coming from population registries that do not correctly distinguish between NAFLD and NASH. We evaluated the prevalence of NAFLD and NASH in peritumoral tissue of resected iCCA (n = 180) and in needle biopsies of matched liver donors. Data of iCCA patients were subsequently analysed to compare NASH-related iCCA (Group A), iCCA arisen in a healthy liver (Group B) or in patients with classical iCCA risk factors (Group C). NASH was found in 22.5% of 129 iCCA patients without known risk factors and in 6.2% of matched controls (risk ratio 3.625, 95% confidence interval 1.723–7.626, p < 0.001), while NAFLD was equally represented in both groups. The overall survival of NASH-related iCCA was inferior to that of patients with healthy liver (38.5 vs. 48.1 months, p = 0.003) and similar to that of patients with known risk factors (31.9 months, p = 0.948), regardless of liver fibrosis. The multivariable Cox regression confirmed NASH as a prognostic factor (hazard ratio 1.773, 95% confidence interval 1.156–2.718, p = 0.009). We concluded that NASH (but not NAFLD) is a risk factor for iCCA and might affect its prognosis. Dissecting NASH from NAFLD by histology is necessary to correctly assess the actual role of these conditions. Prevention protocols for NASH patients should also consider the risk for iCCA and not only HCC. Mechanistic studies aimed to find a direct pathogenic link between NASH and iCCA could add further relevant information.

Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis

2009 ◽  
Vol 51 (2) ◽  
pp. 371-379 ◽  
Author(s):  
Curtis K. Argo ◽  
Patrick G. Northup ◽  
Abdullah M.S. Al-Osaimi ◽  
Stephen H. Caldwell
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Fibrosis Progression ◽  
Alcoholic Steatohepatitis
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