scholarly journals Human liver regeneration following massive hepatic necrosis: Two distinct patterns

2019 ◽  
Vol 35 (1) ◽  
pp. 124-134 ◽  
Author(s):  
Katalin Dezső ◽  
Péter Nagy ◽  
Sándor Paku
Keyword(s):  
Liver Regeneration ◽  
Human Liver ◽  
Hepatic Necrosis ◽  
Massive Hepatic Necrosis

Distribution of hepatic stem cell markers in human liver with massive hepatic necrosis

2010 ◽  
Vol 3 (2) ◽  
pp. 39-45
Author(s):  
Jeong Eun Hwang ◽  
Sang Hak Han ◽  
Ji-Hun Kim ◽  
Yong-Mee Cho ◽  
Eunsil Yu
Keyword(s):  
Stem Cell ◽  
Human Liver ◽  
Hepatic Necrosis ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Hepatic Stem Cell ◽  
Massive Hepatic Necrosis

Regional Radioactivity Discrepancy Between Tc-99m GSA and Tc-99m Phytate Liver Scans in a Patient with Massive Hepatic Necrosis

2002 ◽  
Vol 27 (8) ◽  
pp. 584-588
Author(s):  
SHIRO AKAKI ◽  
MOTOTSUGU SAEKI ◽  
TOSHIHIRO IGUCHI ◽  
YOSHIHIRO OKUMURA ◽  
SHUHEI SATO ◽  
...  
Keyword(s):  
Hepatic Necrosis ◽  
Massive Hepatic Necrosis

Acute Fulminant Hepatic Failure in a Woman Treated With Phenytoin and Trimethoprim-Sulfamethoxazole

2000 ◽  
Vol 124 (12) ◽  
pp. 1800-1803 ◽  
Author(s):  
Marius J-M. Ilario ◽  
Jose E. Ruiz ◽  
Constantine A. Axiotis
Keyword(s):  
Liver Injury ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Acute Hepatic Failure ◽  
Hepatic Necrosis ◽  
Rare Occurrence ◽  
Autopsy Findings ◽  
Massive Hepatic Necrosis

Abstract Massive hepatic necrosis following exposure to phenytoin and trimethoprim-sulfamethoxazole is a rare occurrence and to the best of our knowledge has not been reported previously. Acute hepatic failure following administration of trimethoprim-sulfamethoxazole has rarely been seen, and only 4 cases have been well documented pathologically. We report a case of acute liver failure in a 60-year-old woman following ingestion of phenytoin and trimethoprim-sulfamethoxazole concomitantly over a 9-day period. Autopsy findings revealed acute fulminant hepatic failure. This case demonstrates the effects of chemical-chemical interactions in the potentiation of hepatotoxicity of single agents and specifically illustrates the need for discontinuing trimethoprim-sulfamethoxazole in the presence of early liver injury.

scholarly journals Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits

Toxins ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 695
Author(s):  
Mark Grey Collett ◽  
Zoe Maree Matthews ◽  
Kathleen Henry Parton
Keyword(s):  
New Zealand ◽  
Pilot Trial ◽  
Elevated Serum ◽  
Hepatic Necrosis ◽  
Severe Illness ◽  
Forage Crops ◽  
Brassica Spp ◽  
Massive Hepatic Necrosis ◽  
New Zealand White Rabbits ◽  
Higher Doses

Cattle occasionally develop brassica-associated liver disease (BALD) and photosensitisation when grazing turnip or swede (Brassica spp.) forage crops. The liver toxin in these brassica varieties has yet to be discovered. Progoitrin is the dominant glucosinolate in incriminated crops. Apart from goitrin, progoitrin hydrolysis yields the nitrile, 1-cyano-2-hydroxy-3-butene (CHB), and the epithionitrile, 1-cyano-2-hydroxy-3,4-epithiobutane (CHEB). The two compounds were custom-synthesised. In a small pilot trial, New Zealand White rabbits were given either CHB or CHEB by gavage. Single doses of 0.75 mmol/kg of CHB or 0.25 mmol/kg of CHEB were subtoxic and elicited subclinical effects. Higher doses were severely hepatotoxic, causing periportal to massive hepatic necrosis associated with markedly elevated serum liver biomarkers often resulting in severe illness or death within 24 h. The possibility that one or both of these hepatotoxic nitriles causes BALD in cattle requires further investigation.

Provocation of massive hepatic necrosis by endotoxin after partial hepatectomy in rats

1990 ◽  
Vol 99 (3) ◽  
pp. 771-777 ◽  
Author(s):  
Satoshi Mochida ◽  
Itsuro Ogata ◽  
Keiichi Hirata ◽  
Yasuhiko Ohta ◽  
Shinwa Yamada ◽  
...  
Keyword(s):  
Partial Hepatectomy ◽  
Hepatic Necrosis ◽  
Massive Hepatic Necrosis

Massive Hepatic Necrosis Associated with General Anesthesia

1964 ◽  
Vol 129 (12) ◽  
pp. 1148-1151 ◽  
Author(s):  
Lawrence B. Perry ◽  
John A. Jenicek
Keyword(s):  
General Anesthesia ◽  
Hepatic Necrosis ◽  
Massive Hepatic Necrosis

MASSIVE HEPATIC NECROSIS following general anesthesia*

1962 ◽  
Vol 41 (5) ◽  
pp. 586???592 ◽  
Author(s):  
ROBERT L. TEMPLE ◽  
ROGER A. COTE ◽  
SHERWOOD W. GORENS
Keyword(s):  
General Anesthesia ◽  
Hepatic Necrosis ◽  
Massive Hepatic Necrosis
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