Risk of gastrointestinal bleeding and benefit from colorectal cancer reduction from long-term use of low-dose aspirin: A retrospective study of 612 509 patients

2018 ◽  
Vol 33 (10) ◽  
pp. 1728-1736 ◽  
Author(s):  
Kelvin KF Tsoi ◽  
Felix CH Chan ◽  
Hoyee W Hirai ◽  
Joseph JY Sung
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Study ◽  
Gastrointestinal Bleeding ◽  
Low Dose ◽  
Dose Aspirin ◽  
Low Dose Aspirin

Comparing mortality of colorectal cancer and gastrointestinal bleeding among patients with long-term use of low dose aspirin: A population-based study of 689,209 patients.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 527-527
Author(s):  
Joseph Sung ◽  
Kelvin Kf Tsoi
Keyword(s):  
Colorectal Cancer ◽  
Gastrointestinal Bleeding ◽  
Large Scale ◽  
Low Dose ◽  
Population Based ◽  
Dose Aspirin ◽  
Increased Risk ◽  
Incidence And Mortality ◽  
Low Dose Aspirin

527 Background: Aspirin, commonly used for prevention of cardiovascular and cerebrovascular diseases, is well-known to protect against colorectal cancer (CRC) development but increase risk of gastrointestinal bleeding (GIB). Few large-scale studies have compared the benefit and risk of long-term aspirin usage. This cohort study aims to evaluate the use of low-dose aspirin to prevent CRC and the risk of GIB associated with the aspirin use. Methods: A population-based clinical dataset was used to compare incidence and mortality of CRC and GIB patients receiving low-dose aspirin with sex-and-age matched controls (in 1:2 ratio). Patients with aspirin≤6 months were excluded. Clinical data of 206,243 aspirin users (mean dose 80 mg/day, mean duration 7.7 years) and 482,966 non-users were included. All patients must have at least 10-year follow up on clinical outcome. Results: Among aspirin users 5,776 (2.80%) were diagnosed with CRC; 2,097 (1.02%) died of the malignancy. 16,483 (3.41%) non-users were diagnosed with CRC; 7,963 (1.65%) died of CRC. Using the cox-proportional hazard regression, aspirin usage showed a modest but significant reduction in CRC mortality (HR = 0.65; 95% CI = 0.62 to 0.69). On the other hand, 11,187 (5.42%) aspirin users developed GIB, and 841 (0.41%) died. 15,186 (3.14%) non-users developed GIB, and 1,682 patients (0.35%) died. Aspirin users showed modest but significant increased risk of GIB-related mortality (HR = 1.24; 95% CI = 1.14 to 1.35). Conclusions: The long-term use of low dose aspirin shows preventive effect on CRC, but also increases the associated GIB risk. Considerations of prophylactic use of aspirin should balance the benefit and the risk of this treatment to the target population. [Table: see text]

Lower gastrointestinal bleeding and risk of colorectal cancer in users and non-users of low-dose aspirin

2018 ◽  
Vol 164 ◽  
pp. S239 ◽  
Author(s):  
F. Schønfeldt Troelsen ◽  
D. Körmendiné Farkas ◽  
A. Gulbech Ording ◽  
S. Friis ◽  
R. Erichsen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastrointestinal Bleeding ◽  
Low Dose ◽  
Lower Gastrointestinal Bleeding ◽  
Dose Aspirin ◽  
Low Dose Aspirin

scholarly journals Public health impact of low-dose aspirin on colorectal cancer, cardiovascular disease and safety in the UK – Results from micro-simulation model

2021 ◽  
Vol 36 ◽  
pp. 100851
Author(s):  
Jorne Biccler ◽  
Kaatje Bollaerts ◽  
Pareen Vora ◽  
Elodie Sole ◽  
Luis Alberto Garcia Rodriguez ◽  
...  
Keyword(s):  
Public Health ◽  
Colorectal Cancer ◽  
Cardiovascular Disease ◽  
Simulation Model ◽  
Low Dose ◽  
Health Impact ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Micro Simulation ◽  
The Uk

Risk of upper gastrointestinal bleeding associated with use of low-dose aspirin

2000 ◽  
Vol 95 (9) ◽  
pp. 2218-2224 ◽  
Author(s):  
Henrik Toft Sorensen ◽  
Lene Mellemkjaer ◽  
William J. Blot ◽  
Gunnar Lauge Nielsen ◽  
Flemming Hald Steffensen ◽  
...  
Keyword(s):  
Gastrointestinal Bleeding ◽  
Low Dose ◽  
Upper Gastrointestinal Bleeding ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Upper Gastrointestinal

scholarly journals Effects of low-dose aspirin on the osseointegration process in rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Ana Carolina Lupepsa ◽  
Paula Vargas-Sanchez ◽  
Marcella Goetz Moro ◽  
Leomar Emanuel Almeida Mecca ◽  
Marcela Claudino ◽  
...  
Keyword(s):  
Low Dose ◽  
Inhibitory Effect ◽  
Control Group ◽  
Implant Placement ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Male Wistar Rats ◽  
Bone To Implant Contact ◽  
Bone Deposition

Abstract Background Several drugs are capable of promoting changes in bone metabolism. The aim of this study was to evaluate the effect of long-term low-dose aspirin (LDA) therapy on implant osseointegration. Methods Male Wistar rats were divided into 4 groups (n = 8/group) according to oral gavage solution received prior (42 days) to the implant surgery on the tibia. The control group was treated with saline solution for 7 (CG-7) and 28 (CG-28) days. The use of low-dose aspirin was performed in AG groups (6.75 mg/kg of aspirin) for 7 (AG-7) and 28 (AG-28) days. After experimental periods, histomorphometric evaluation of bone-to-implant contact (BIC) and the bone area between threads (BABT) was performed. Results Reduced BIC values were detected in AG-7 (62.8% ± 17.1) group compared to AG-28 (91.9% ± 5.4), CG-7 (82.7% ± 15.2), and CG-28 (89.9% ± 9.7). BABT evaluation revealed lower values in AG-7 (70.9% ± 15.2) compared to AG-28 (95.4% ± 3.7) and CG-28 (87.1% ± 10.2) groups. Conclusions The treatment with low doses of aspirin promoted a discrete inhibitory effect in the early stages (7 days) of repair after implant placement, specifically in the bone deposition. However, these effects were not detected in the late stages (28 days), considering BIC and BABT parameters.

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