Evidence for the association between IgG-antimitochondrial antibody and biochemical response to ursodeoxycholic acid treatment in primary biliary cholangitis

2017 ◽  
Vol 32 (3) ◽  
pp. 659-666 ◽  
Author(s):  
Libo Tang ◽  
Ruihua Zhong ◽  
Xuanqiu He ◽  
Weibin Wang ◽  
Jinhong Liu ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Acid Treatment ◽  
Biochemical Response ◽  
Primary Biliary Cholangitis ◽  
Antimitochondrial Antibody

Worse Response to Ursodeoxycholic Acid in Primary Biliary Cholangitis Patients with Autoimmune Hepatitis Features

2020 ◽  
Author(s):  
Maoyao Wen ◽  
Ruoting Men ◽  
Xiaoli Fan ◽  
Yi Shen ◽  
Ping Ni ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Ursodeoxycholic Acid ◽  
Total Bilirubin ◽  
Response Rate ◽  
Immunosuppressive Agents ◽  
Biochemical Response ◽  
Primary Biliary Cholangitis ◽  
Lower Response Rate ◽  
One Year ◽  
Glutamyl Transpeptidase

Background: There is limited evidence on the treatment response of primary biliary cholangitis (PBC) with autoimmune hepatitis (AIH) features but not meet the criteria of PBC-AIH syndromes. This study was to elucidate the clinical characteristics of PBC patients with features of AIH. Methods: We included patients with diagnostic criteria of PBC. All patients were treated with ursodeoxycholic acid (UDCA) and without immunosuppressive agents for more than one year. The biochemical response was evaluated at one year after treatment of UCDA. Results: Among 432 patients with PBC, 166 (38.4%) patients did not achieve biochemical response within one year of UDCA treatment. Non-responders had lower albumin (ALB) level and higher immunoglobulin G (IgG), alanine transaminase (ALT), alanine aminotransferase (AST), alkaline phosphatase (ALP), glutamyl transpeptidase (GGT) and total bilirubin (TB) levels (P < 0.05). The response rates were significantly lower in patients with elevated level of IgG or ALT or AST. Moreover, the higher the IgG or AST level was, the lower the response rate was in patients with PBC regardless of cirrhosis. For patients with cirrhosis, there was no differences among patients with different level of ALT. Patients in the PBC with AIH features group had a significant lower response rate than patients in the PBC-only group. Among the 139 patients who underwent liver biopsy, 54 were non-responsive to UDCA and 48 (88.9%) shown mild interface hepatitis. Conclusion: In conclusion, PBC patients with AIH features had a worse response to UDCA therapy.

scholarly journals Predictive Model of Ursodeoxycholic Acid Treatment Response in Primary Biliary Cholangitis

2021 ◽  
Vol 000 (000) ◽  
pp. 000-000
Author(s):  
Yanyun Shu ◽  
Yuhu Song ◽  
Tao Bai ◽  
Xiaoli Pan ◽  
Haitao Shang ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Predictive Model ◽  
Treatment Response ◽  
Acid Treatment ◽  
Primary Biliary Cholangitis

Ursodeoxycholic Acid Treatment Preferentially Improves Overall Survival Among African Americans With Primary Biliary Cholangitis

2020 ◽  
Vol 115 (2) ◽  
pp. 262-270 ◽  
Author(s):  
Stuart C. Gordon ◽  
Kuan-Han Hank Wu ◽  
Keith Lindor ◽  
Christopher L. Bowlus ◽  
Carla V. Rodriguez ◽  
...  
Keyword(s):  
Overall Survival ◽  
African Americans ◽  
Ursodeoxycholic Acid ◽  
Acid Treatment ◽  
Primary Biliary Cholangitis
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