Gastrointestinal: Metastatic gastrinoma with secretory differentiation to ACTH

2016 ◽  
Vol 31 (10) ◽  
pp. 1669-1669
Author(s):  
J Matta ◽  
MR Oliver
Keyword(s):  
Secretory Differentiation

A T.E.M. study of mouse mammary epithelial cell secretory differentiation cultured on collagen and Matrigel

1991 ◽  
Vol 49 ◽  
pp. 188-189
Author(s):  
W.N. Bentham ◽  
V. Rocha
Keyword(s):  
Cell Culture ◽  
Mammary Epithelial ◽  
Secretory Process ◽  
Cell Culture System ◽  
Protein Maturation ◽  
Cell Culture Techniques ◽  
Culture Techniques ◽  
Mouse Mammary Epithelial Cell ◽  
Secretory Differentiation

It has been an interest of our lab to develop a mammary epethelial cell culture system that faithfully duplicates the in vivo condition of the lactating gland. Since the introduction of collagen as a matrix on which cells are cultivated other E.C.M. type matrices have been made available and are used in many cell culture techniques. We have previously demonstrated that cells cultured on collagen and Matrigel do not differentiate as they do in vivo. It seems that these cultures often produce cells that show a disruption in the secretory process. The appearance of large ribosomal studded vesicles, that specifically label with antibody to casein, suggest an interruption of both protein maturation and secretion at the E.R. to golgi transition. In this report we have examined cultures on collagen and Matrigel at relative high and low seeding densities and compared them to cells from the in vivo condition.

Ciliary and Secretory Differentiation of Normal Human Middle Ear Epithelial Cells

2002 ◽  
Vol 122 (3) ◽  
pp. 270-275 ◽  
Author(s):  
Jae Young Choi ◽  
Chang-Hoon Kim ◽  
Won-Sang Lee ◽  
Hee-Nam Kim ◽  
Kyoung-Seob Song ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Middle Ear ◽  
Normal Human ◽  
Human Middle Ear ◽  
Secretory Differentiation

scholarly journals Protein tyrosine phosphatase 1B restrains mammary alveologenesis and secretory differentiation

Development ◽  
2012 ◽  
Vol 140 (1) ◽  
pp. 117-125 ◽  
Author(s):  
E. S. Milani ◽  
H. Brinkhaus ◽  
R. Dueggeli ◽  
I. Klebba ◽  
U. Mueller ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Secretory Differentiation

scholarly journals PTHrP Induces STAT5 Activation, Secretory Differentiation and Mammary Tumor Progression

2021 ◽  
Author(s):  
Diego Y. Grinman ◽  
Kata Boras-Granic ◽  
Farzin M. Takyar ◽  
Pamela Dann ◽  
Julie R. Hens ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Milk Production ◽  
Mammary Tumor ◽  
Cancer Biology ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Breast Cancers ◽  
The Impact ◽  
Secretory Differentiation

Background: Parathyroid hormone-related protein (PTHrP) is required for embryonic breast development and has important functions during lactation, when it is produced by alveolar epithelial cells and secreted into the maternal circulation to mobilize skeletal calcium used for milk production. PTHrP is also produced by breast cancers and GWAS studies suggest that it influences breast cancer risk. However, the exact functions of PTHrP in breast cancer biology remain unsettled. Methods: We developed a tetracyline-regulated, MMTV (mouse mammary tumor virus)-driven model of PTHrP overexpression in mammary epithelial cells (Tet-PTHrP mice) and bred these mice with the MMTV-PyMT (polyoma middle tumor-antigen) breast cancer model to analyze the impact of PTHrP overexpression on normal mammary gland biology and in breast cancer progression. Results: Overexpression of PTHrP in luminal epithelial cells caused alveolar hyperplasia and secretory differentiation of the mammary epithelium with milk production. This was accompanied by activation of Stat5 and increased expression of E74-like factor-5 (Elf5). In MMTV-PyMT mice, overexpression of PTHrP (Tet-PTHrP;PyMT mice) shortened tumor latency and accelerated tumor growth, ultimately reducing overall survival. Tumors overproducing PTHrP also displayed increased expression of nuclear pSTAT5 and Elf5, increased expression of markers of secretory differentiation and milk constituents, and histologically resembled secretory carcinomas of the breast. Overexpression of PTHrP within cells isolated from tumors, but not PTHrP exogenously added to cell culture media, led to activation of STAT5 and milk protein gene expression. In addition, neither ablating the Type 1 PTH/PTHrP receptor (PTH1R) in epithelial cells or treating Tet-PTHrP;PyMT mice with an anti-PTH1R antibody prevented secretory differentiation or altered tumor latency. These data suggest that PTHrP acts in a cell-autonomous, intracrine manner. Finally, expression of PTHrP in human breast cancers is associated with expression of genes involved in milk production and STAT5 signaling. Conclusions: Our study suggests that PTHrP promotes pathways leading to secretory differentiation and proliferation in both normal mammary epithelial cells and in breast tumor cells.

Multiple Eccrine Syringofibroadenoma of Mascaro of the Lower Extremity

2016 ◽  
Vol 106 (6) ◽  
pp. 433-438
Author(s):  
Danae L. Lowell ◽  
Nichol L. Salvo ◽  
William J. Weily ◽  
Michael Swiatek ◽  
Hannah Sahli
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Lower Extremity ◽  
Benign Lesion ◽  
Unknown Etiology ◽  
Secretory Differentiation

Eccrine syringofibroadenoma (ESFA) is a rare benign lesion of ductal and secretory differentiation exhibiting multiple cutaneous polymorphic presentations with an unknown etiology. We present a case of ESFA that uniquely exhibited large, thick, verrucous-like hyperplastic growths as well as superficial shiny mosaic plaques and deep ulcerations in three different anatomical locations in the same patient. The diagnosis of ESFA was confirmed histologically after biopsies were performed on all of the affected areas. In addition to a case report and literature review, we also present classification, clinical, and histologic aspects of ESFA.

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