Downregulation of serotonin reuptake transporter gene expression in healing colonic mucosa in presence of remaining low-grade inflammation in ulcerative colitis

2016 ◽  
Vol 31 (8) ◽  
pp. 1443-1452 ◽  
Author(s):  
Yasumasa Tada ◽  
Shunji Ishihara ◽  
Kousaku Kawashima ◽  
Nobuhiko Fukuba ◽  
Hiroki Sonoyama ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ulcerative Colitis ◽  
Serotonin Reuptake ◽  
Colonic Mucosa ◽  
Low Grade ◽  
Transporter Gene ◽  
Serotonin Reuptake Transporter ◽  
Low Grade Inflammation

scholarly journals The serotonin reuptake transporter is reduced in the epithelium of active Crohn’s disease and ulcerative colitis

2020 ◽  
Vol 319 (6) ◽  
pp. G761-G768
Author(s):  
Jonas Woll Jørandli ◽  
Silje Thorsvik ◽  
Helene Kolstad Skovdahl ◽  
Benedikt Kornfeld ◽  
Siri Sæterstad ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Intestinal Epithelium ◽  
Serotonin Reuptake ◽  
Tryptophan Hydroxylase ◽  
Intestinal Inflammation ◽  
Serotonin Synthesis ◽  
Crohn’S Colitis ◽  
Tnf Α ◽  
Serotonin Reuptake Transporter

The serotonin reuptake transporter is potently reduced in inflamed areas of Crohn’s ileitis, Crohn’s colitis, and ulcerative colitis. The changes are localized to the intestinal epithelium and can be induced by TNF-α. The serotonin synthesis through tryptophan hydroxylase 1 is unchanged. This regulation is suggested as a mechanism underlying the increased extracellular serotonin levels associated with intestinal inflammation.

scholarly journals Corticotropin-Releasing Factor and Toll-Like Receptor Gene Expression Is Associated with Low-Grade Inflammation in Irritable Bowel Syndrome Patients with Depression

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Song Jizhong ◽  
Wang Qiaomin ◽  
Wang Chao ◽  
Li Yanqing
Keyword(s):  
Gene Expression ◽  
Irritable Bowel Syndrome ◽  
Inflammatory Response ◽  
Psychiatric Symptoms ◽  
Corticotropin Releasing Factor ◽  
Low Grade ◽  
Lower Grade ◽  
Toll Like Receptor ◽  
Irritable Bowel ◽  
Low Grade Inflammation

The mechanism of low-grade inflammation in irritable bowel syndrome (IBS) is unclear; our research concentrates on the involvement of the corticotropin-releasing factor (CRF) and Toll-like receptor (TLR) gene expression in the process of low-grade inflammation in IBS patients with depression. This study suggests more IBS patients are presenting with the states of depression and anxiety. IBS patients with depression have shown a lower grade inflammatory response and an imbalance of the inflammatory response. CRF1, CRF2, TLR2, and TLR4 in IBS patients with depression are significantly higher than those without depression and controls. Thus, activation of the CRF-TLR associated pathways produces an inflammatory reaction, which can concurrently affect the digestive tract and the CNS and induce the corresponding digestive and psychiatric symptoms.

scholarly journals Obesity, Insulin Resistance, and Colorectal Cancer: Could miRNA Dysregulation Play a Role?

2019 ◽  
Vol 20 (12) ◽  
pp. 2922 ◽  
Author(s):  
Francesca Cirillo ◽  
Cecilia Catellani ◽  
Chiara Sartori ◽  
Pietro Lazzeroni ◽  
Sergio Amarri ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Insulin Resistance ◽  
Low Grade ◽  
Regulate Gene Expression ◽  
New Perspective ◽  
Obesity And Cancer ◽  
Low Grade Inflammation ◽  
Regulate Gene

Obesity is associated with insulin resistance and low-grade inflammation. Insulin resistance is a risk factor for cancer. A recent chapter in epigenetics is represented by microRNAs (miRNAs), which post-transcriptionally regulate gene expression. Dysregulated miRNA profiles have been associated with diseases including obesity and cancer. Herein we report dysregulated miRNAs in obesity both in animal models and in humans, and we also document dysregulated miRNAs in colorectal cancer (CRC), as example of an obesity-related cancer. Some of the described miRNAs are found to be similarly dysregulated both in obesity, insulin resistance (IR), and CRC. Thus, we present miRNAs as a potential molecular link between obesity and CRC onset and development, giving a new perspective on the role of miRNAs in obesity-associated cancers.

Effect of Long-Term Mesalamine Therapy on Cancer-Associated Gene Expression in Colonic Mucosa of Patients with Ulcerative Colitis

2018 ◽  
Vol 64 (3) ◽  
pp. 740-750 ◽  
Author(s):  
Manisha Bajpai ◽  
Darren N. Seril ◽  
James Van Gurp ◽  
Xin Geng ◽  
Janet Alvarez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ulcerative Colitis ◽  
Colonic Mucosa
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