The tumor-suppressive function of miR-1 by targeting LASP1 and TAGLN2 in esophageal squamous cell carcinoma

2016 ◽  
Vol 31 (2) ◽  
pp. 384-393 ◽  
Author(s):  
Yan-Yan Du ◽  
Lian-Mei Zhao ◽  
Liang Chen ◽  
Mei-Xiang Sang ◽  
Jie Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Suppressive Function ◽  
Tumor Suppressive Function

scholarly journals Characterization of Tumor Suppressive Function of cornulin in Esophageal Squamous Cell Carcinoma

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e68838 ◽  
Author(s):  
Kai Chen ◽  
Yan Li ◽  
Yongdong Dai ◽  
Jiangchao Li ◽  
Yanru Qin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Suppressive Function ◽  
Tumor Suppressive Function

scholarly journals Tumor-Suppressive Function of miR-139-5p in Esophageal Squamous Cell Carcinoma

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77068 ◽  
Author(s):  
Ran Liu ◽  
Miao Yang ◽  
Yanli Meng ◽  
Juan Liao ◽  
Jingyi Sheng ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Suppressive Function ◽  
Tumor Suppressive Function

scholarly journals Tumor Suppressive Function of NQO1 in Cutaneous Squamous Cell Carcinoma (SCC) Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Qing-Ling Zhang ◽  
Xue Mei Li ◽  
De-De Lian ◽  
Ming Ji Zhu ◽  
Su-Hyuk Yim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Proliferation ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Mesenchymal Transition ◽  
Suppressive Function ◽  
Phosphorylated Akt ◽  
Tumor Suppressive Function

Cutaneous squamous cell carcinoma (SCC) is a common cancer that significantly decreases the quality of life. It is known that external stimulus such as ultraviolet (UV) radiation induces cutaneous SCC via provoking oxidative stress. NAD(P)H dehydrogenase 1 (NQO1) is a ubiquitous flavoenzyme that functions as a guardian against oxidative stress. However, the effect of NQO1 on cutaneous SCC is not clearly elucidated. In this study, we investigated the effect of NQO1 on cutaneous SCC cells using the recombinant adenoviruses that can upregulate and/or downregulate NQO1 expression. Overexpression of NQO1 resulted in significant decrease of cell proliferation and colony forming activity of SCC lines (SCC12 and SCC13 cells). By contrast, knockdown of NQO1 increased the cell proliferation and colony forming activity. Accordingly, the levels of proliferation-related regulators, such as Cyclin D1, Cyclin E, PCNA, SOX2, and p63, were decreased by the overexpression of NQO1, while those were increased by knockdown of NQO1. In addition, NQO1 affected the invasion and migration of SCC cells in a very similar way, with the regulation of epithelial-mesenchymal transition- (EMT-) related molecules, including E-cadherin, N-cadherin, Vimentin, Snail, and Slug. Finally, the overexpression of NQO1 decreased the level of phosphorylated AKT, JNK, and p38 MAPK, while the knockdown of NQO1 increased the level of phosphorylated signaling molecules. Based on these data, NQO1 has tumor suppressive function in cutaneous SCC cells.

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