Tailored therapy for the refractory GERD patients by combined multichannel intraluminal impedance-pH monitoring

2016 ◽  
Vol 31 (2) ◽  
pp. 350-354 ◽  
Author(s):  
Yinglian Xiao ◽  
Mengya Liang ◽  
Sui Peng ◽  
Ning Zhang ◽  
Minhu Chen
Keyword(s):  
Ph Monitoring ◽  
Multichannel Intraluminal Impedance ◽  
Tailored Therapy ◽  
Intraluminal Impedance ◽  
Refractory Gerd ◽  
Multichannel Intraluminal Impedance Ph

scholarly journals Tailored therapy guided by multichannel intraluminal impedance pH monitoring for refractory non-erosive reflux disease

2017 ◽  
Vol 8 (9) ◽  
pp. e3040-e3040 ◽  
Author(s):  
Nunzio Ranaldo ◽  
Giuseppe Losurdo ◽  
Andrea Iannone ◽  
Mariabeatrice Principi ◽  
Michele Barone ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Ph Monitoring ◽  
Multichannel Intraluminal Impedance ◽  
Tailored Therapy ◽  
Intraluminal Impedance ◽  
Multichannel Intraluminal Impedance Ph

Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review

2019 ◽  
Vol 160 (5) ◽  
pp. 762-782 ◽  
Author(s):  
Jerome R. Lechien ◽  
Lee M. Akst ◽  
Abdul Latif Hamdan ◽  
Antonio Schindler ◽  
Petros D. Karkos ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Laryngopharyngeal Reflux ◽  
Ph Monitoring ◽  
Diagnosis And Treatment ◽  
Cochrane Library ◽  
Diagnostic Tools ◽  
Multichannel Intraluminal Impedance ◽  
Intraluminal Impedance ◽  
Number Of Patients ◽  
Multichannel Intraluminal Impedance Ph

Objective To review the current literature about the epidemiology, clinical presentation, diagnosis, and treatment of laryngopharyngeal reflux (LPR). Data Sources PubMed, Cochrane Library, and Scopus. Methods A comprehensive review of the literature on LPR epidemiology, clinical presentation, diagnosis, and treatment was conducted. Using the PRISMA statement, 3 authors selected relevant publications to provide a critical analysis of the literature. Conclusions The important heterogeneity across studies in LPR diagnosis continues to make it difficult to summarize a single body of thought. Controversies persist concerning epidemiology, clinical presentation, diagnosis, and treatment. No recent epidemiologic study exists regarding prevalence and incidence with the use of objective diagnostic tools. There is no survey that evaluates the prevalence of symptoms and signs on a large number of patients with confirmed LPR. Regarding diagnosis, an increasing number of authors used multichannel intraluminal impedance–pH monitoring, although there is no consensus regarding standardization of the diagnostic criteria. The efficiency of proton pump inhibitor (PPI) therapy remains poorly demonstrated and misevaluated by incomplete clinical tools that do not take into consideration many symptoms and extralaryngeal findings. Despite the recent advances in knowledge about nonacid LPR, treatment protocols based on PPIs do not seem to have evolved. Implications for Practice The development of multichannel intraluminal impedance–pH monitoring and pepsin and bile salt detection should be considered for the establishment of a multiparameter diagnostic approach. LPR treatment should evolve to a more personalized regimen, including diet, PPIs, alginate, and magaldrate according to individual patient characteristics. Multicenter international studies with a standardized protocol could improve scientific knowledge about LPR.

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