Lymphocyte activation gene 3 negatively regulates the function of intrahepatic hepatitis C virus-specific CD8+ T cells

2015 ◽  
Vol 30 (12) ◽  
pp. 1788-1795 ◽  
Author(s):  
Na Chen ◽  
Yehong Liu ◽  
Yonghong Guo ◽  
Yunru Chen ◽  
Xiaojing Liu ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cd8 T Cells ◽  
Lymphocyte Activation ◽  
Lymphocyte Activation Gene

Detection of naïve hepatitis C virus-specific CD8+ T cells in chronically infected patients

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
J Schmidt ◽  
DA Price ◽  
C Neumann-Haefelin ◽  
HE Blum ◽  
R Thimme
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cd8 T Cells

scholarly journals Quantitative analysis of hepatitis C virus-specific CD8+ T cells in peripheral blood and liver using peptide-MHC tetramers

1999 ◽  
Vol 96 (10) ◽  
pp. 5692-5697 ◽  
Author(s):  
X.-S. He ◽  
B. Rehermann ◽  
F. X. Lopez-Labrador ◽  
J. Boisvert ◽  
R. Cheung ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Quantitative Analysis ◽  
Hepatitis C ◽  
Cd8 T Cells ◽  
Peripheral Blood ◽  
Mhc Tetramers

The use of class-I HLA tetramers for the detection of hepatitis C virus NS3-specific CD8+ T cells in patients with chronic infection

2004 ◽  
Vol 287 (1-2) ◽  
pp. 91-99 ◽  
Author(s):  
F.Xavier López-Labrador ◽  
Xiao-Song He ◽  
Marina Berenguer ◽  
Ramsey C. Cheung ◽  
Teresa L. Wright ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cd8 T Cells ◽  
Chronic Infection ◽  
Class I

scholarly journals Apoptotic Epitope–Specific CD8+T Cells and Interferon Signaling Intersect in Chronic Hepatitis C Virus Infection

2015 ◽  
Vol 213 (4) ◽  
pp. 674-683 ◽  
Author(s):  
Helene Martini ◽  
Alessandra Citro ◽  
Carmela Martire ◽  
Gabriella D'Ettorre ◽  
Giancarlo Labbadia ◽  
...  
Keyword(s):  
T Cells ◽  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Cd8 T Cells ◽  
Interferon Signaling ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

scholarly journals Sa1525 – Visne Analysis of Hepatitis C Virus-Specific Cd8 T Cells from Direct Acting Antiviral-Treated Chronic Hcv Patients and Hcv Resolvers

2019 ◽  
Vol 156 (6) ◽  
pp. S-1232
Author(s):  
Jihad Aljabban ◽  
Pierre Tonnerre ◽  
Dan Kvistad ◽  
Max Robidoux ◽  
Joelle Brown ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cd8 T Cells ◽  
Direct Acting Antiviral ◽  
Chronic Hcv ◽  
Direct Acting

scholarly journals Cutting Edge: Identification of Hepatitis C Virus-Specific CD8+T Cells Restricted by Donor HLA Alleles following Liver Transplantation

2004 ◽  
Vol 173 (9) ◽  
pp. 5355-5359 ◽  
Author(s):  
Hugo R. Rosen ◽  
David J. Hinrichs ◽  
Rachel L. Leistikow ◽  
Glenda Callender ◽  
Anne M. Wertheimer ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cd8 T Cells ◽  
Cutting Edge ◽  
Hla Alleles

scholarly journals Priming of Antiviral CD8 T Cells without Effector Function by a Persistently Replicating Hepatitis C-Like Virus

2020 ◽  
Vol 94 (10) ◽  
Author(s):  
Alex S. Hartlage ◽  
Christopher M. Walker ◽  
Amit Kapoor
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Animal Models ◽  
Cd8 T Cells ◽  
Persistent Infection ◽  
Cd8 T Cell ◽  
Effector Function ◽  
Viral Escape

ABSTRACT Immune-competent animal models for the hepatitis C virus (HCV) are nonexistent, impeding studies of host-virus interactions and vaccine development. Experimental infection of laboratory rats with a rodent hepacivirus isolated from Rattus norvegicus (RHV) is a promising surrogate model due to its recapitulation of HCV-like chronicity. However, several aspects of rat RHV infection remain unclear, for instance, how RHV evades host adaptive immunity to establish persistent infection. Here, we analyzed the induction, differentiation, and functionality of RHV-specific CD8 T cell responses that are essential for protection against viral persistence. Virus-specific CD8 T cells targeting dominant and subdominant major histocompatibility complex class I epitopes proliferated considerably in liver after RHV infection. These populations endured long term yet never acquired antiviral effector functions or selected for viral escape mutations. This was accompanied by the persistent upregulation of programmed cell death-1 and absent memory cell formation, consistent with a dysfunctional phenotype. Remarkably, transient suppression of RHV viremia with a direct-acting antiviral led to the priming of CD8 T cells with partial effector function, driving the selection of a viral escape variant. These data demonstrate an intrinsic abnormality within CD8 T cells primed by rat RHV infection, an effect that is governed at least partially by the magnitude of early virus replication. Thus, this model could be useful in investigating mechanisms of CD8 T cell subversion, leading to the persistence of hepatotropic pathogens such as HCV. IMPORTANCE Development of vaccines against hepatitis C virus (HCV), a major cause of cirrhosis and cancer, has been stymied by a lack of animal models. The recent discovery of an HCV-like rodent hepacivirus (RHV) enabled the development of such a model in rats. This platform recapitulates HCV hepatotropism and viral chronicity necessary for vaccine testing. Currently, there are few descriptions of RHV-specific responses and why they fail to prevent persistent infection in this model. Here, we show that RHV-specific CD8 T cells, while induced early at high magnitude, do not develop into functional effectors capable of controlling virus. This defect was partially alleviated by short-term treatment with an HCV antiviral. Thus, like HCV, RHV triggers dysfunction of virus-specific CD8 T cells that are vital for infection resolution. Additional study of this evasion strategy and how to mitigate it could enhance our understanding of hepatotropic viral infections and lead to improved vaccines and therapeutics.

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