scholarly journals Use of non-invasive serum glycan markers to distinguish non-alcoholic steatohepatitis from simple steatosis

2015 ◽  
Vol 30 (3) ◽  
pp. 528-534 ◽  
Author(s):  
Yasushi Yamasaki ◽  
Kazuhiro Nouso ◽  
Koji Miyahara ◽  
Nozomu Wada ◽  
Chihiro Dohi ◽  
...  
Keyword(s):  
Simple Steatosis ◽  
Non Invasive ◽  
Alcoholic Steatohepatitis

Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis

2006 ◽  
Vol 111 (2) ◽  
pp. 135-143 ◽  
Author(s):  
Piero Portincasa ◽  
Ignazio Grattagliano ◽  
Bernhard H. Lauterburg ◽  
Vincenzo O. Palmieri ◽  
Giuseppe Palasciano ◽  
...  
Keyword(s):  
Body Size ◽  
Stable Isotope ◽  
Predictive Value ◽  
Breath Tests ◽  
Alcoholic Fatty Liver ◽  
Simple Steatosis ◽  
Non Invasive ◽  
Alcoholic Steatohepatitis ◽  
Metabolic Functions ◽  
Mitochondrial Functions

Effectively assessing subtle hepatic metabolic functions by novel non-invasive tests might be of clinical utility in scoring NAFLD (non-alcoholic fatty liver disease) and in identifying altered metabolic pathways. The present study was conducted on 39 (20 lean and 19 obese) hypertransaminasemic patients with histologically proven NAFLD {ranging from simple steatosis to severe steatohepatitis [NASH (non-alcoholic steatohepatitis)] and fibrosis} and 28 (20 lean and eight overweight) healthy controls, who underwent stable isotope breath testing ([13C]methacetin and [13C]ketoisocaproate) for microsomal and mitochondrial liver function in relation to histology, serum hyaluronate, as a marker of liver fibrosis, and body size. Compared with healthy subjects and patients with simple steatosis, NASH patients had enhanced methacetin demethylation (P=0.001), but decreased (P=0.001) and delayed (P=0.006) ketoisocaproate decarboxylation, which was inversely related (P=0.001) to the degree of histological fibrosis (r=−0.701), serum hyaluronate (r=−0.644) and body size (r=−0.485). Ketoisocaproate decarboxylation was impaired further in obese patients with NASH, but not in patients with simple steatosis and in overweight controls. NASH and insulin resistance were independently associated with an abnormal ketoisocaproate breath test (P=0.001). The cut-off value of 9.6% cumulative expired 13CO2 for ketoisocaproate at 60 min was associated with the highest prediction (positive predictive value, 0.90; negative predictive value, 0.73) for NASH, yielding an overall sensitivity of 68% and specificity of 94%. In conclusion, both microsomal and mitochondrial functions are disturbed in NASH. Therefore stable isotope breath tests may usefully contribute to a better and non-invasive characterization of patients with NAFLD.

A single non-invasive model to diagnose non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)

2014 ◽  
Vol 29 (12) ◽  
pp. 2006-2013 ◽  
Author(s):  
Munkhzul Otgonsuren ◽  
Michael J. Estep ◽  
Nayeem Hossain ◽  
Elena Younossi ◽  
Spencer Frost ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Alcoholic Steatohepatitis ◽  
Alcoholic Fatty Liver Disease

Non-invasive diagnosis of non-alcoholic steatohepatitis and fibrosis with the use of omics and supervised learning: A proof of concept study

Metabolism ◽  
2019 ◽  
Vol 101 ◽  
pp. 154005 ◽  
Author(s):  
Nikolaos Perakakis ◽  
Stergios A. Polyzos ◽  
Alireza Yazdani ◽  
Aleix Sala-Vila ◽  
Jannis Kountouras ◽  
...  
Keyword(s):  
Supervised Learning ◽  
Proof Of Concept ◽  
Concept Study ◽  
Non Invasive ◽  
Alcoholic Steatohepatitis

scholarly journals Fibrosis non-invasive tests capture changes in patient-reported outcomes of patients with advanced non-alcoholic steatohepatitis

2020 ◽  
Vol 73 ◽  
pp. S171
Author(s):  
Zobair Younossi ◽  
Stephen Harrison ◽  
Quentin Anstee ◽  
Eric Lawitz ◽  
Vincent Wai-Sun Wong ◽  
...  
Keyword(s):  
Patient Reported Outcomes ◽  
Non Invasive ◽  
Alcoholic Steatohepatitis ◽  
Patient Reported
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