Regulation by resveratrol of the cellular factors mediating liver damage and regeneration after acute toxic liver injury

2014 ◽  
Vol 29 (3) ◽  
pp. 603-613 ◽  
Author(s):  
Che-Chang Chan ◽  
Kuei-Chuan Lee ◽  
Yi-Hsiang Huang ◽  
Chung-Kai Chou ◽  
Han-Chieh Lin ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Damage ◽  
Cellular Factors ◽  
Toxic Liver Injury ◽  
Acute Toxic

The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo

2009 ◽  
Vol 390 (10) ◽  
Author(s):  
Marie-Luise Berres ◽  
Christian Trautwein ◽  
Mirko Moreno Zaldivar ◽  
Petra Schmitz ◽  
Katrin Pauels ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Damage ◽  
Immune Modulation ◽  
Scavenger Receptor ◽  
Wild Type ◽  
Protein Levels ◽  
Inflammatory Chemokines ◽  
Toxic Liver Injury ◽  
Acute Toxic

Abstract The chemokine decoy receptor D6 is a promiscuous chemokine receptor lacking classical signaling functions. It negatively regulates inflammation by targeting CC chemokines to cellular internalization and degradation. Here we analyze the function of D6 in acute CCl4-induced liver damage in constitutive D6-/- and wild-type mice. The degree of liver injury was assessed by liver histology, serum transaminases, IL-6, and TNFα mRNA expression. Protein levels of D6 ligands (CCL2, CCL3, CCL5) and the non-D6-ligand CXCL9 within the livers were determined by ELISAs. The intrahepatic infiltration of immune cells was characterized by FACS. Genetic deletion of D6 led to prolonged liver damage after acute CCl4 administration. The augmented liver damage in D6-/- mice was associated with increased protein levels of intrahepatic inflammatory chemokines CCL2, CCL3, and CCL5 after 48 h, whereas CXCL9 was not different between knockout and wild-type mice. Functionally, increased intra-hepatic CC chemokine concentrations led to increased infiltration of CD45+ leukocytes, which were mainly identified as T and NK cells. In conclusion, the chemokine scavenger receptor D6 has a non-redundant role in acute toxic liver injury in vivo. These results support the importance of post-translational chemokine regulation and describe a new mechanism of immune modulation within the liver.

Endogenous glucocorticoids released during acute toxic liver injury enhance hepatic IL-10 synthesis and release

1999 ◽  
Vol 276 (1) ◽  
pp. G199-G205 ◽  
Author(s):  
Mark G. Swain ◽  
Caroline Appleyard ◽  
John Wallace ◽  
Howard Wong ◽  
Tai Le
Keyword(s):  
Liver Injury ◽  
Inflammatory Response ◽  
Glucocorticoid Receptor ◽  
Receptor Antagonist ◽  
Mrna Expression ◽  
Elevated Serum ◽  
Ru 486 ◽  
Tnf Α ◽  
Toxic Liver Injury ◽  
Acute Toxic

Endogenous glucocorticoids are known to play a role in the regulation of the inflammatory response possibly by modulating pro- and anti-inflammatory cytokine expression. We examined endogenous glucocorticoid secretion, hepatic damage, tumor necrosis factor-α (TNF-α), and interleukin-10 (IL-10) mRNA expression and release in rats treated with carbon tetrachloride (CCl4) after treatment with vehicle or a glucocorticoid receptor antagonist (RU-486). Rats treated with CCl4 demonstrated striking elevations of plasma corticosterone levels. Inhibition of endogenous glucocorticoid activity by pretreatment with the glucocorticoid receptor antagonist RU-486 resulted in augmented CCl4-mediated hepatotoxicity, as reflected by histology and serum transaminase levels, which were independent of alterations in serum TNF-α levels or hepatic mRNA expression. CCl4 treatment resulted in enhanced hepatic IL-10 mRNA expression and elevated serum IL-10 levels, which were markedly attenuated by glucocorticoid receptor blockade. In summary, significant endogenous glucocorticoid release occurs during acute toxic liver injury in the rat and suppresses the inflammatory response independent of effects on TNF-α but possibly by upregulating hepatic IL-10 production.

scholarly journals Hepatoprotective action of the self-emulsifying system with berberine in experimental toxic liver injury by acetaminofen

2019 ◽  
Vol 16 (1) ◽  
pp. 56-64
Author(s):  
I. P. Sutsko ◽  
A. G. Shlyahtun ◽  
O. V. Titko ◽  
N. V. Yankevich ◽  
P. G. Telegin ◽  
...  
Keyword(s):  
Liver Injury ◽  
Antioxidant System ◽  
Liver Damage ◽  
The Self ◽  
Sulfhydryl Groups ◽  
Hepatoprotective Effect ◽  
Free Form ◽  
Toxic Liver Damage ◽  
Toxic Liver Injury

The hepatoprotective effect of the self-emulsifying composition with berberine was studied in the model of toxic liver damage in rats with acetaminophen and its hepatoprotective properties were analyzed in comparison with the use of berberine in free form. The course introduction of self-emulsifying composition with berberine before intoxication of rats with acetaminophen to a greater extent inhibits the development of cytolysis of hepatocytes, and also promotes the enhancement of the glutathione unit of the antioxidant system, increasing the content of total and free sulfhydryl groups, compared with the introduction of free berberine in animals.

FRI-089-Genetic deletion of Keap in hepatocytes improves liver damage, but triggers hepatitis in an Nrf2-dependent manner, in experimental toxic liver injury

2019 ◽  
Vol 70 (1) ◽  
pp. e423-e424
Author(s):  
Laura Moran Blanco ◽  
Nuria López-Alcántara ◽  
Olga Estévez ◽  
Pierluigi Ramadori ◽  
Christoph J. Wruck ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Damage ◽  
Dependent Manner ◽  
Genetic Deletion ◽  
Toxic Liver Injury

Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride

2002 ◽  
Vol 37 (2) ◽  
pp. 198-205 ◽  
Author(s):  
Andreas Geier ◽  
Suk Kyum Kim ◽  
Thomas Gerloff ◽  
Christoph G Dietrich ◽  
Frank Lammert ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Organic Anion ◽  
Organic Anion Transporters ◽  
Anion Transporters ◽  
Toxic Liver Injury ◽  
Acute Toxic

scholarly journals Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β

2016 ◽  
Vol 64 (1) ◽  
pp. 118-127 ◽  
Author(s):  
Ghulam Ilyas ◽  
Enpeng Zhao ◽  
Kun Liu ◽  
Yu Lin ◽  
Lydia Tesfa ◽  
...  
Keyword(s):  
Liver Injury ◽  
Interleukin 1Β ◽  
Down Regulation ◽  
Toxic Liver Injury ◽  
Acute Toxic
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