Microvascular invasion in small hepatocellular carcinoma: Is it predictable with preoperative diffusion-weighted imaging?

2014 ◽  
Vol 29 (2) ◽  
pp. 330-336 ◽  
Author(s):  
Pengju Xu ◽  
Mengsu Zeng ◽  
Kai Liu ◽  
Yan Shan ◽  
Chen Xu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diffusion Weighted Imaging ◽  
Microvascular Invasion ◽  
Small Hepatocellular Carcinoma ◽  
Diffusion Weighted

Preoperative prediction of the microvascular invasion of hepatocellular carcinoma with diffusion-weighted imaging

2012 ◽  
Vol 18 (10) ◽  
pp. 1171-1178 ◽  
Author(s):  
Young Joo Suh ◽  
Myeong-Jin Kim ◽  
Jin-Young Choi ◽  
Mi-Suk Park ◽  
Ki Whang Kim
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diffusion Weighted Imaging ◽  
Microvascular Invasion ◽  
Preoperative Prediction ◽  
Diffusion Weighted

scholarly journals Prediction of microvascular invasion of hepatocellular carcinoma with preoperative diffusion-weighted imaging

Medicine ◽  
2017 ◽  
Vol 96 (33) ◽  
pp. e7754 ◽  
Author(s):  
Jinkun Zhao ◽  
Xubin Li ◽  
Kun Zhang ◽  
Xiaoyu Yin ◽  
Xiangfu Meng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diffusion Weighted Imaging ◽  
Microvascular Invasion ◽  
Diffusion Weighted

scholarly journals Diffusion-Weighted Imaging Reflects Tumor Grading and Microvascular Invasion in Hepatocellular Carcinoma

Liver Cancer ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 10-24
Author(s):  
Alexey Surov ◽  
Maciej Pech ◽  
Jazan Omari ◽  
Frank Fischbach ◽  
Robert Damm ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diffusion Coefficient ◽  
Diffusion Weighted Imaging ◽  
Microvascular Invasion ◽  
Data Bases ◽  
Tumor Grading ◽  
Diffusion Weighted ◽  
Apparent Diffusion ◽  
Adc Values

<b><i>Background:</i></b> To date, there are inconsistent data about relationships between diffusion-weighted imaging (DWI) and tumor grading/microvascular invasion (MVI) in hepatocellular carcinoma (HCC). Our purpose was to systematize the reported results regarding the role of DWI in prediction of tumor grading/MVI in HCC. <b><i>Method:</i></b> MEDLINE library, Scopus, and Embase data bases were screened up to December 2019. Overall, 29 studies with 2,715 tumors were included into the analysis. There were 20 studies regarding DWI and tumor grading, 8 studies about DWI and MVI, and 1 study investigated DWI, tumor grading, and MVI in HCC. <b><i>Results:</i></b> In 21 studies (1,799 tumors), mean apparent diffusion coefficient (ADC) values (ADC<sub>mean</sub>) were used for distinguishing HCCs. ADC<sub>mean</sub> of G1–3 lesions overlapped significantly. In 4 studies (461 lesions), minimum ADC (ADC<sub>min</sub>) was used. ADC<sub>min</sub> values in G1/2 lesions were over 0.80 × 10<sup>−3</sup> mm<sup>2</sup>/s and in G3 tumors below 0.80 × 10<sup>−3</sup> mm<sup>2</sup>/s. In 4 studies (241 tumors), true diffusion (<i>D</i>) was reported. A significant overlapping of <i>D</i> values between G1, G2, and G3 groups was found. ADC<sub>mean</sub> and MVI were analyzed in 9 studies (1,059 HCCs). ADC<sub>mean</sub> values of MIV+/MVI− lesions overlapped significantly. ADC<sub>min</sub> was used in 4 studies (672 lesions). ADC<sub>min</sub> values of MVI+ tumors were in the area under 1.00 × 10<sup>−3</sup> mm<sup>2</sup>/s. In 3 studies (227 tumors), <i>D</i> was used. Also, <i>D</i> values of MVI+ lesions were predominantly in the area under 1.00 × 10<sup>−3</sup> mm<sup>2</sup>/s. <b><i>Conclusion:</i></b> ADC<sub>min</sub> reflects tumor grading, and ADC<sub>min</sub> and <i>D</i> predict MVI in HCC. Therefore, these DWI parameters should be estimated for every HCC lesion for pretreatment tumor stratification. ADC<sub>mean</sub> cannot predict tumor grading/MVI in HCC.

scholarly journals Study on clinical application of susceptibility weighted imaging ombined with diffusion weighted imaging in patients with Liver Cirrhosis complicated with small Hepatocellular Carcinoma

2021 ◽  
Vol 37 (3) ◽  
Author(s):  
Zhi-bo Hou ◽  
Fei Zhao ◽  
Bin Zhang ◽  
Chun-zhu Zhang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Clinical Application ◽  
Diffusion Weighted Imaging ◽  
Iron Deposition ◽  
Susceptibility Weighted Imaging ◽  
Small Hepatocellular Carcinoma ◽  
Coincidence Rate ◽  
Diffusion Weighted ◽  
Significant Difference

Objectives: To evaluate the clinical value of susceptibility weighted imaging (SWI) combined with diffusion weighted imaging (DWI) in patients with liver cirrhosis complicated with small hepatocellular carcinoma (SHCC). Methods: A total of 40 patients with liver cirrhosis and 44 nodules were treated with conventional nuclear magnetic scanning (T1WI, T2WI) and SWI combined with DWI; the results were judged by two senior physicians; the t test, χ2 test, rank sum test, and other methods were used for contrastive analysis of the pathological results of different scanning methods after operation or puncture. Results: Contrast analysis of the different MRI scanning methods and pathological results showed that among the 32 nodules of small hepatocellular carcinoma, 24 cases were diagnosed by conventional MRI, with the coincidence rate being 75%, 30 cases were diagnosed by SWI DWI, with the coincidence rate being 96%; significant difference was found between the two groups (p=0. 04). Significant differences were found in the specificity, sensitivity and accuracy of different scanning methods in the diagnosis of small hepatocellular carcinoma (specificity, accuracy, p=0.04; sensitivity p=0.01). The SWI of small hepatocellular carcinoma nodules showed hyperintensity, and the degree of iron deposition was low. Significant difference was found between small hepatocellular carcinoma nodules and other nodules (comparison of SWI signal degree, p=0.01; comparison of iron deposition degree, p=0.00). Conclusion: The SWI of small hepatocellular carcinoma nodules showed hyperintensity, and the degree of iron deposition was low. The coincidence rate of SWI+DWI scanning is higher than that of conventional scanning methods in the diagnosis of small hepatocellular carcinoma, and the difference in specificity, sensitivity and accuracy has obvious advantages. SWI+DWI scanning can improve the detection rate of liver cirrhosis complicated with small hepatocellular carcinoma. doi: https://doi.org/10.12669/pjms.37.3.3822 How to cite this:Hou ZB, Zhao F, Zhang B, Zhang CZ. Study on clinical application of susceptibility weighted imaging combined with diffusion weighted imaging in patients with Liver Cirrhosis complicated with small Hepatocellular Carcinoma. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3822 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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