Impact of molecular adsorbent recirculating system on renal recovery in type-1 hepatorenal syndrome patients with chronic liver failure

2013 ◽  
Vol 28 (6) ◽  
pp. 1019-1024 ◽  
Author(s):  
Laurence Lavayssière ◽  
Siba Kallab ◽  
Isabelle Cardeau-Desangles ◽  
Marie Béatrice Nogier ◽  
Olivier Cointault ◽  
...  
Keyword(s):  
Liver Failure ◽  
Hepatorenal Syndrome ◽  
Chronic Liver ◽  
Renal Recovery ◽  
Chronic Liver Failure ◽  
Molecular Adsorbent Recirculating System ◽  
Type 1 Hepatorenal Syndrome ◽  
Molecular Adsorbent

scholarly journals Probit-analysis for assessing the effectiveness of various treatment methods for chronic liver failure

2014 ◽  
Vol 95 (3) ◽  
pp. 348-351
Author(s):  
D E Kutepov
Keyword(s):  
Liver Failure ◽  
Plasma Exchange ◽  
Conventional Treatment ◽  
High Volume ◽  
Probit Analysis ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Treatment Methods ◽  
Molecular Adsorbent Recirculating System ◽  
Molecular Adsorbent

Aim. To estimate the validity of probit-analysis for assessing the effectiveness of various treatment methods for chronic liver failure. Methods. The study included 292 patients with chronic liver failure. All patients were distributed to four groups, conventional treatment was performed in all patients. Patients of the 2nd group were additionally administered plasma exchange, of the 3rd group - plasma exchange and high volume continuous veno-venous hemofiltration, of the 4th - molecular adsorbent recirculating system (MARS). To determine the medium lethal time (time at which 50% of patients pass away, ТL50), probit-analysis based on studying the association between the time logarithms and probits corresponding to the observed effects, was used. Results. Standardization of patients’ mortality rate, allowing to exclude biases associated with differences of chronic liver failure severity at admission, was performed. Probit-analysis showed that there were no significant differences in between male and female patients regardless of used treatment methods. ТL50 in patients of any gender treated only by conventional methods was significantly lower compared to other methods of treatment. There was a trend of ТL50 increase in the following sequence: conventional treatment → plasma exchange → plasma exchange and high volume continuous veno-venous hemofiltration → molecular adsorbent recirculating system. Conclusion. Probit-analysis allows to determine the time of 50% mortality (ТL50) in patients with chronic liver failure. Treatment using extracorporeal methods of treatment (plasma exchange, plasma exchange and high volume continuous veno-venous hemofiltration, molecular adsorbent recirculating system) is significantly more effective compared to conventional treatment.

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