Basal release of nitric oxide in the mesenteric artery in portal hypertension and cirrhosis: Role of dimethylarginine dimethylaminohydrolase

2013 ◽  
Vol 28 (5) ◽  
pp. 880-886 ◽  
Author(s):  
Eva Serna ◽  
María Dolores Mauricio ◽  
Paloma Lluch ◽  
Gloria Segarra ◽  
Belén Cortina ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Portal Hypertension ◽  
Mesenteric Artery ◽  
Dimethylarginine Dimethylaminohydrolase ◽  
Basal Release

scholarly journals INVOLVEMENT OF CATECHOLAMINES IN THE MYOCARDIUM OF RATS SUBMITTED TO EXPERIMENTAL MODEL OF PORTAL HYPERTENSION

2018 ◽  
Vol 31 (3) ◽  
Author(s):  
Antonella VINHOLI ◽  
Marília Da Cruz FAGUNDES ◽  
Danieli Cristina PIGOZZO ◽  
Fernando Bermudez KUBRUSLY ◽  
Luiz Fernando KUBRUSLY ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Tyrosine Hydroxylase ◽  
Portal Vein ◽  
Mesenteric Artery ◽  
Wistar Rats ◽  
Statistical Significance ◽  
Immunohistochemical Analysis ◽  
Immunohistochemical Expression ◽  
Marked Area

ABSTRACT Background: The role of autonomic nervous system in the development and maintenance of portal hypertension is not fully elucidated. It is known that the gene expression of norepinephrine in the superior mesenteric artery varies with time, and it may contribute for splanchnic vasodilation and its consequent hemodynamic repercussions. It is still not known exactly how the adrenergic expression behaves at the heart level in the initial stages of this process. Aim: To evaluate the immunohistochemical expression of the enzyme tyrosine hydroxylase (tyrosine 3-monooxygenase), involved in the synthesis of norepinephrine, in the myocardium of rats submitted to partial ligation of the portal vein. Methods: Twenty-four Wistar rats were divided into two groups: Sham Operated and Portal Hypertension. The partial ligation was performed in the Portal Hypertension group, and after 1/6/24 h and 3/5/14 days the animals were euthanized. Immunohistochemical analysis was performed to quantify the expression of the stained enzyme using the ImageJ program. Results: The Portal Hypertension group expressed percentages between 4.6-6% of the marked area, while the Sham Operated group varied between 4-5%. Although there was no statistical significance, the percentage stained in the Portal Hypertension group followed an increasing pattern in the first 6 h and a decreasing pattern after 24 h, which was not observed in the Sham Operated group. Conclusion: The expression of noradrenaline in rat myocardium during the first two weeks after partial ligation of the portal vein, with tyrosine hydroxylase as marker, did not show differences between groups over time.

The role of nitric oxide in the hyperdynamic circulatory syndrome associated with portal hypertension

1995 ◽  
Vol 23 (2) ◽  
pp. 218-224 ◽  
Author(s):  
Philippe Sogni ◽  
Richard Moreau ◽  
Adrián Gadano ◽  
Didier Lebrec
Keyword(s):  
Nitric Oxide ◽  
Portal Hypertension

86 Role of tumor necrosis factor and nitric oxide in portal hypertension

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 197-197
Author(s):  
N SKILL ◽  
N HEODORAKIS ◽  
Y WANG ◽  
M METZ ◽  
E REDMOND ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Portal Hypertension ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Necrosis Factor

Baicalin-Induced Vascular Response In Rat Mesenteric Artery: Role Of Endothelial Nitric Oxide

2002 ◽  
Vol 29 (8) ◽  
pp. 721-724 ◽  
Author(s):  
Yu Huang ◽  
Suk Ying Tsang ◽  
Xiaoqiang Yao ◽  
Chi Wai Lau ◽  
Ya Lun Su ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mesenteric Artery ◽  
Vascular Response ◽  
Rat Mesenteric Artery ◽  
Endothelial Nitric Oxide

Role of nitric oxide and neuropeptides in neurogenic vasodilatation of the guinea pig mesenteric artery

1995 ◽  
Vol 279 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Yasuaki Gyoda ◽  
Yuichi Tsukada ◽  
Akira Saito ◽  
Katsutoshi Goto
Keyword(s):  
Nitric Oxide ◽  
Guinea Pig ◽  
Mesenteric Artery ◽  
Neurogenic Vasodilatation

Role of aortic nitric oxide synthase 3 (eNOS) in the systemic vasodilation of portal hypertension

2000 ◽  
Vol 119 (1) ◽  
pp. 196-200 ◽  
Author(s):  
Dominique Pateron ◽  
Khalid A. Tazi ◽  
Philippe Sogni ◽  
Jörg Heller ◽  
Carine Chagneau ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Portal Hypertension ◽  
Nitric Oxide Synthase ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

Enhancement of Contraction of Rat Mesenteric Artery by Acteoside:  Role of Endothelial Nitric Oxide

2002 ◽  
Vol 65 (7) ◽  
pp. 990-995 ◽  
Author(s):  
Wing-Yin Tam ◽  
Zhen-Yu Chen ◽  
Zhen-Dan He ◽  
Xiaoqiang Yao ◽  
Chi-Wai Lau ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mesenteric Artery ◽  
Rat Mesenteric Artery ◽  
Endothelial Nitric Oxide
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