scholarly journals Functional gastrointestinal diseases in children: Facing the rising tide

2013 ◽  
Vol 28 (2) ◽  
pp. 208-210
Author(s):  
Shaman Rajindrajith ◽  
Niranga M Devanarayana
Keyword(s):  
Gastrointestinal Diseases ◽  
Functional Gastrointestinal Diseases

scholarly journals Association Between Functional Gastrointestinal Diseases and Exposure to Abuse in Teenagers

2014 ◽  
Vol 60 (5) ◽  
pp. 386-392 ◽  
Author(s):  
N. M. Devanarayana ◽  
S. Rajindrajith ◽  
M. S. Perera ◽  
S. W. Nishanthanie ◽  
A. Karunanayake ◽  
...  
Keyword(s):  
Gastrointestinal Diseases ◽  
Functional Gastrointestinal Diseases

scholarly journals Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yukiko Ohara ◽  
Lisa Fujimura ◽  
Akemi Sakamoto ◽  
Youichi Teratake ◽  
Shuichi Hiraoka ◽  
...  
Keyword(s):  
Genetic Background ◽  
Survival Rates ◽  
Gastrointestinal Diseases ◽  
Negative Regulator ◽  
Enteric Neurons ◽  
Enteric Neuron ◽  
Protein Coding ◽  
Underlying Mechanisms ◽  
Functional Gastrointestinal Diseases ◽  
Deficient Mice

AbstractThe Kif26a protein-coding gene has been identified as a negative regulator of the GDNF-Ret signaling pathway in enteric neurons. The aim of this study was to investigate the influence of genetic background on the phenotype of Kif26a-deficient (KO, −/−) mice. KO mice with both C57BL/6 and BALB/c genetic backgrounds were established. Survival rates and megacolon development were compared between these two strains of KO mice. Functional bowel assessments and enteric neuron histopathology were performed in the deficient mice. KO mice with the BALB/c genetic background survived more than 400 days without evidence of megacolon, while all C57BL/6 KO mice developed megacolon and died within 30 days. Local enteric neuron hyperplasia in the colon and functional bowel abnormalities were observed in BALB/c KO mice. These results indicated that megacolon and enteric neuron hyperplasia in KO mice are influenced by the genetic background. BALB/c KO mice may represent a viable model for functional gastrointestinal diseases such as chronic constipation, facilitating studies on the underlying mechanisms and providing a foundation for the development of treatments.

Mo1603 Diagnostic Significance of ROME III Questionnaire, Endoscopy and Ultrasound in Functional Gastrointestinal Diseases

2016 ◽  
Vol 150 (4) ◽  
pp. S726-S727 ◽  
Author(s):  
Tao Bai ◽  
Wenfeng Wang ◽  
Lei Zhang ◽  
Jun Song ◽  
Yudong Jiang ◽  
...  
Keyword(s):  
Gastrointestinal Diseases ◽  
Diagnostic Significance ◽  
Rome Iii ◽  
Functional Gastrointestinal Diseases
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