scholarly journals Retraction statement: Vacuolating cytotoxin A (vacA) and cytotoxin‐associated gene A (cagA) genotypes of resistant Helicobacter pylori strains isolated from raw and pasteurized milk

2019 ◽  
Vol 39 (3) ◽  
pp. e12647
Keyword(s):  
Helicobacter Pylori ◽  
Vacuolating Cytotoxin ◽  
Pasteurized Milk ◽  
Cytotoxin Associated Gene A ◽  
Vacuolating Cytotoxin A

scholarly journals The Interrelationship between Cytotoxin-Associated Gene A, Vacuolating Cytotoxin, and Helicobacter pylori-Related Diseases

1996 ◽  
Vol 173 (5) ◽  
pp. 1171-1175 ◽  
Author(s):  
J. F. L. Weel ◽  
R. W. M. van der Hulst ◽  
Y. Gerrits ◽  
P. Roorda ◽  
M. Feller ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Vacuolating Cytotoxin ◽  
Cytotoxin Associated Gene A

Vacuolating cytotoxin A (VacA) – A multi-talented pore-forming toxin from Helicobacter pylori

Toxicon ◽  
2016 ◽  
Vol 118 ◽  
pp. 27-35 ◽  
Author(s):  
Muhammad Junaid ◽  
Aung Khine Linn ◽  
Mohammad Bagher Javadi ◽  
Sarbast Al-Gubare ◽  
Niaz Ali ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Vacuolating Cytotoxin ◽  
Vacuolating Cytotoxin A

Rapid Detected and Diagnostic Assessment Vacuolating Cytotoxin A (vacA) Gene of Helicobacter pylori by Loop-Mediated Isothermal Amplification (LAMP)

2020 ◽  
Vol 20 (3) ◽  
pp. 1478-1485
Author(s):  
Yingying Zheng ◽  
Jiali Wu ◽  
Yuan Yang ◽  
Mengqiong Liu ◽  
Dongdong Li
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Juice ◽  
Detection Method ◽  
Lamp Assay ◽  
Isothermal Amplification ◽  
Vacuolating Cytotoxin ◽  
Loop Mediated Isothermal Amplification ◽  
Specificity And Sensitivity ◽  
H Pylori ◽  
Vacuolating Cytotoxin A

The loop-mediated isothermal amplification (LAMP) assay as efficient and convenient detection method was applied to detect the vacuolating cytotoxin A (vacA) gene of Helicobacter pylori (H. pylori). The extracted genomic DNA of H. pylori, which was purified through magnetic nanoparticles (MNPs), was amplified through the LAMP reaction using designed primers. The effect of LAMP detected on H. pylori vacA gene was evaluated through agarose gel electrophoresis in a gel imaging system and fluorescence-intensity analysis after addition of fluorescent dye. 11 pathogenic bacterial strains of different species were found to be negative for vacA, while only a single positive result was obtained for H. pylori. The minimum detection limit of the vacA gene was established as 100 fg. We used the primers with specificity and sensitivity, which were designed by the specificity analysis and sensitivity analysis system. Once developed, the LAMP assay was be used to the detection of the vacA gene in the gastric juice of patients. In conclusion, the LAMP assay is an efficient and fast tool for detection of the H. pylori vacA gene, and also for direct detection of the vacA gene in the gastric juice of patients, with high sensitivity and specificity. Most importantly, the proposed detection method shows promising potential for clinical application in the future, where it can greatly reduce the difficulty of detection and also shorten detection times.

scholarly journals Modulation of Host Cell Signal Transduction Pathways by Helicobacter Pylori Infection

2005 ◽  
Vol 19 (7) ◽  
pp. 415-420 ◽  
Author(s):  
Peter JM Ceponis ◽  
Nicola L Jones
Keyword(s):  
Signal Transduction ◽  
Helicobacter Pylori ◽  
Host Cell ◽  
Current Knowledge ◽  
Vacuolating Cytotoxin ◽  
Cell Signal ◽  
Cytotoxin Associated Gene A ◽  
Cell Signal Transduction ◽  
Present Summary ◽  
Study Group Meeting

Bacterial pathogens modulate host cell signal transduction responses to establish infection and cause disease. The purpose of the present summary, first presented at the Canadian Helicobacter Study Group meeting, is to discuss current knowledge of specific Helicobacter pylori factors, including the vacuolating cytotoxin, cytotoxin-associated gene A and the type four secretion system encoded by the cytotoxin-associated gene pathogenicity island and review the host cell signal transduction cascades that they modulate.

scholarly journals Statins’ Regulation of the Virulence Factors of Helicobacter pylori and the Production of ROS May Inhibit the Development of Gastric Cancer

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1293
Author(s):  
Ting-Yu Lin ◽  
Wen-Hsi Lan ◽  
Ya-Fang Chiu ◽  
Chun-Lung Feng ◽  
Cheng-Hsun Chiu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Virulence Factors ◽  
Treatment Strategies ◽  
Vacuolating Cytotoxin ◽  
Cholesterol Levels ◽  
Cytotoxin Associated Gene A ◽  
H Pylori ◽  
Cellular Components ◽  
Development Of Gastric Cancer

Conventionally, statins are used to treat high cholesterol levels. They exhibit pleiotropic effects, such as the prevention of cardiovascular disease and decreased cancer mortality. Gastric cancer (GC) is one of the most common cancers, ranking as the third leading global cause of cancer-related deaths, and is mainly attributed to chronic Helicobacter pylori infection. During their co-evolution with hosts, H. pylori has developed the ability to use the cellular components of the host to evade the immune system and multiply in intracellular niches. Certain H. pylori virulence factors, including cytotoxin-associated gene A (CagA), vacuolating cytotoxin A (VacA), and cholesterol-α-glucosyltransferase (CGT), have been shown to exploit host cholesterol during pathogenesis. Therefore, using statins to antagonize cholesterol synthesis might prove to be an ideal strategy for reducing the occurrence of H. pylori-related GC. This review discusses the current understanding of the interplay of H. pylori virulence factors with cholesterol and reactive oxygen species (ROS) production, which may prove to be novel therapeutic targets for the development of effective treatment strategies against H. pylori-associated GC. We also summarize the findings of several clinical studies on the association between statin therapy and the development of GC, especially in terms of cancer risk and mortality.

Sign in / Sign up

Export Citation Format

Share Document