Safety Evaluation and Antibacterial Activity of Enterococci Isolated from Lighvan Cheese

2016 ◽  
Vol 37 (1) ◽  
pp. e12289 ◽  
Author(s):  
Mehri Joghataei ◽  
Masoud Yavarmanesh ◽  
Mohammad Reza Edalatian Dovom
Dose-Response ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 155932582095679
Author(s):  
Muhammad Amjad Chishti ◽  
Ejaz Mohi-Ud-Din ◽  
Shahbaz Ahmad Zakki ◽  
Muhammad Rahil Aslam ◽  
Sheraz Siddiqui ◽  
...  

The present study was conducted to evaluate the antibacterial activity, in vitro and in vivo cytotoxicity, cell viability and safety of Eastern Medicine coded medicinal formulation Eczegone comprising extracts of Azadirachta indica (Azin) , Fumaria indica (Fuin) , Sphaeranthus indicus (Spin) and Lawsonia inermis (Lain). This work also evaluated antibacterial activity of Eczegone formulation having above mentioned plants ethanolic extracts against different bacteria’s by disk diffusion method. In vitro toxicity of Eczegone formulation was investigated by using human skin keratinocytes HaCaT cell line, crystal violet stained cells, and methyl tetrazolium cytotoxicity (MTT) assay. In vivo acute oral and dermal cytotoxicity was determined by using Swiss albino mice and albino rabbits, respectively. The Eczegone formulation showed antibacterial activity against 3 gram negative bacteria including Escherichia coli, Klebsiella pneumonia, Proteus vulgaris and a gram positive Staphylococcus aureus. We didn’t observe any toxic effect of Eczegone formulation on the skin keratinocytes. Furthermore, the Ezcegone formulation was non-irritant according to draize score (OECD TG404, 2002). After rigorous safety evaluation by in vitro and in vivo acute oral and dermal toxicity analysis, we concluded that Eczegone formualtion possessses antibacterial effects and is safe, non-toxic, non-irritant, and the drug would be subjected for further biochemical and clinical studies.


2020 ◽  
Vol 27 (12) ◽  
pp. 3465-3473
Author(s):  
Mariela González-Renteria ◽  
María del Carmen Monroy-Dosta ◽  
Xochitl Guzmán-García ◽  
Irma Hernández-Calderas ◽  
y Miguel Angel Ramos-Lopez

2004 ◽  
Author(s):  
R. Beyer ◽  
T. J. Ayres ◽  
J. A. Mandell ◽  
J. Giffard ◽  
M. Larkin
Keyword(s):  

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
J Reichling ◽  
U Suschke ◽  
A Suter

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
N Padilla-Montaño ◽  
IL Bazzocchi ◽  
L Moujir

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
P Panichayupakaranant ◽  
P Puttarak

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
SA Dandlen ◽  
AC Figueiredo ◽  
LG Pedro ◽  
JG Barroso ◽  
MG Miguel ◽  
...  

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