Stabilizing the primary emulsion with hydrophobic emulsifiers and salt for encapsulating herbal extracts in a double emulsion

2018 ◽  
Vol 42 (8) ◽  
pp. e13699 ◽  
Author(s):  
Urmila Choudhary ◽  
Latha Sabikhi ◽  
Shaik Abdul Hussain ◽  
Kaushik Khamrui ◽  
Vivek Sharma ◽  
...  
Keyword(s):  
Double Emulsion ◽  
Herbal Extracts ◽  
Primary Emulsion

Influence of Process Parameters on the Characteristics of Hydrophilic Drug-Loaded Microparticles through Double Emulsion Solvent Evaporation Technique

2019 ◽  
Vol 819 ◽  
pp. 252-257 ◽  
Author(s):  
Lalinthip Sutthapitaksakul ◽  
Pornsak Sriamornsak
Keyword(s):  
Process Parameters ◽  
Double Emulsion ◽  
Solvent Evaporation ◽  
Water Phase ◽  
Distilled Water ◽  
Influence Of Process Parameters ◽  
Hydrophilic Drug ◽  
Stirring Time ◽  
Primary Emulsion ◽  
Outer Water

The purpose of this study was to investigate the influence of process parameters on the characteristics of microparticles using double emulsion solvent evaporation method for encapsulation of hydrophilic drug. Donepezil hydrochloride (DPH), a reversible cholinesterase inhibitor, was selected as a model hydrophilic drug. Prior to conducting an experiment, the target particle size of microparticles was set at approximately 200 μm. The investigated process parameters include pH of outer water phase, stirring time, polymer amount, and volume of outer water phase. The results showed that DPH-loaded microparticles was successfully prepared in two steps. In the first step, the primary emulsion was prepared by dissolving DPH in distilled water before emulsifying in dichloromethane (DCM) containing different amounts of poly(butylmethacrylate-co-2-dimethylaminoethyl-methacrylate-co-methyl-methacrylate) (PBM-DM-MM) using ultrasonic probe. In the second step, the primary emulsion was emulsified in polyvinyl alcohol (PVA) solution by overhead stirrer to prepare double emulsion. After solvent evaporation, the microparticles were collected by centrifugation and washed with distilled water. Based on the statistical analysis, stirring time, polymer amount and volume of outer water phase were the main significant parameters influencing particle size of microparticles.

scholarly journals Effect of pH on the stability of W1/O/W2 double emulsion stabilized by combination of biosilica and Tween-20

2018 ◽  
Vol 215 ◽  
pp. 01028 ◽  
Author(s):  
Lanny Sapei ◽  
Tokok Adiarto ◽  
Roi Handomo ◽  
Sonny Hutomo Chandra
Keyword(s):  
Aqueous Phase ◽  
Rice Husk ◽  
Environmental Sustainability ◽  
Double Emulsion ◽  
Continuous Phase ◽  
Tween 20 ◽  
Acidic Ph ◽  
Effect Of Ph ◽  
Primary Emulsion ◽  
The Stability

Indonesia is amongst agricultural countries whose majority of the population consume rice as their staple food. Rice rice production tends to increase year by year followed by the increasing of their byproducts such as rice husks. The majority of rice husk waste has been generally thrown away by burning on site which cause pollution and may negatively impact on the environmental sustainability. In fact, rice husk waste contains of about 20% silica which potentially be used as emulsion stabilizers. Biosilica could stabilize the interface between water and oil due to their hydrophilicity and hydrophobicity characteristics in nature. However, their wettability was greatly influenced by pH. In this experiment, the effect of pH of the outer continuous phase (W2) was investigated. The primary emulsion (W1/O) was prepared by mixing a 40% water phase containing gelatin 3% w/w relative to the aqueous phase and Tween-20 of 1.1% w/w relative to the primary emulsion with the remaining oil phase for 5 minutes. The primary emulsions were then dispersed into the aqueous phase (W2) of various pH (2; 3; and 5.7) by using a mixture of Tween-20 and biosilica as emulsifiers. The result showed that the most stable double emulsion was obtained upon the acidic pH of 2. There was no differences between the stability of double emulsion prepared at pH 2 and that of pH 3 after 7 days. However those prepared without pH adjustment (5.7) tended to be instable in the long-term. This implied that acidic pH would increase the packing density of biosilica in the interfaces thus enhancing the barrier properties of the droplets against coalescences. A stable food grade double emulsion would be very beneficial to develop low-fat emulsion products in various food applications. Furthermore, the inner aqueous phase could be used as a vehicle to encapsulate bio-active agents such as nutrients or antioxidants for the advancement of developments of functional food products.

In vitro evaluation of the effect of selected herbal extracts on drug transport across porcine jejunal tissue

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
C Tarirai ◽  
A Viljoen ◽  
P Chinyemba ◽  
A Khatib ◽  
P Jiyane ◽  
...  
Keyword(s):  
Drug Transport ◽  
Herbal Extracts ◽  
In Vitro Evaluation

Anti-adhesive activity of herbal extracts against Campylobacter jejuni

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
K Bensch ◽  
J Tiralongo ◽  
A Matthias ◽  
K Bone ◽  
R Lehmann ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
Herbal Extracts

In vitro strategy to quantify changes in hepatobiliary drug clearance by herbal extracts

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
JP Jackson ◽  
K Freeman ◽  
J Hatfield ◽  
B St Claire ◽  
C Hubert ◽  
...  
Keyword(s):  
Drug Clearance ◽  
Herbal Extracts

In vitro study of the interaction between human gut microbiota and herbal extracts using willow bark extract as an example

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
EM Pferschy-Wenzig ◽  
K Koskinen ◽  
C Moissl-Eichinger ◽  
R Bauer
Keyword(s):  
Gut Microbiota ◽  
In Vitro Study ◽  
Vitro Study ◽  
Bark Extract ◽  
Herbal Extracts ◽  
Human Gut ◽  
Human Gut Microbiota ◽  
Willow Bark
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