Aeromonas veronii virulence and adhesion attenuation mediated by the gene aodp

2021 ◽  
Author(s):  
Lei Zhang ◽  
Shengnan Jin ◽  
Chao Feng ◽  
Haichao Song ◽  
Sayed Haidar Abbas Raza ◽  
...  
Keyword(s):  
Aeromonas Veronii

scholarly journals Network-based analysis of virulence factors for uncovering Aeromonas veronii pathogenesis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hong Li ◽  
Xiang Ma ◽  
Yanqiong Tang ◽  
Dan Wang ◽  
Ziding Zhang ◽  
...  
Keyword(s):  
Virulence Factors ◽  
Bacterial Pathogen ◽  
Signal Transduction Pathway ◽  
Immune Defense ◽  
Ppi Network ◽  
Host Proteins ◽  
Homologous Proteins ◽  
Aeromonas Veronii ◽  
Regulatory Systems ◽  
Network Modules

Abstract Background Aeromonas veronii is a bacterial pathogen in aquaculture, which produces virulence factors to enable it colonize and evade host immune defense. Given that experimental verification of virulence factors is time-consuming and laborious, few virulence factors have been characterized. Moreover, most studies have only focused on single virulence factors, resulting in biased interpretation of the pathogenesis of A. veronii. Results In this study, a PPI network at genome-wide scale for A. veronii was first constructed followed by prediction and mapping of virulence factors on the network. When topological characteristics were analyzed, the virulence factors had higher degree and betweenness centrality than other proteins in the network. In particular, the virulence factors tended to interact with each other and were enriched in two network modules. One of the modules mainly consisted of histidine kinases, response regulators, diguanylate cyclases and phosphodiesterases, which play important roles in two-component regulatory systems and the synthesis and degradation of cyclic-diGMP. Construction of the interspecies PPI network between A. veronii and its host Oreochromis niloticus revealed that the virulence factors interacted with homologous proteins in the host. Finally, the structures and interacting sites of the virulence factors during interaction with host proteins were predicted. Conclusions The findings here indicate that the virulence factors probably regulate the virulence of A. veronii by involving in signal transduction pathway and manipulate host biological processes by mimicking and binding competitively to host proteins. Our results give more insight into the pathogenesis of A. veronii and provides important information for designing targeted antibacterial drugs.

scholarly journals Enhancement of the production of L-glutaminase, an anticancer enzyme, from Aeromonas veronii by adaptive and induced mutation techniques

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0181745 ◽  
Author(s):  
S. Aravinth Vijay Jesuraj ◽  
Md. Moklesur Rahman Sarker ◽  
Long Chiau Ming ◽  
S. Marylin Jeya Praya ◽  
M. Ravikumar ◽  
...  
Keyword(s):  
Induced Mutation ◽  
Aeromonas Veronii

scholarly journals Structural Studies of the Lipopolysaccharide of Aeromonas veronii bv. sobria Strain K133 which Represents New Provisional Serogroup PGO1 Prevailing among Mesophilic Aeromonads on Polish Fish Farms

2021 ◽  
Vol 22 (8) ◽  
pp. 4272
Author(s):  
Katarzyna Dworaczek ◽  
Maria Kurzylewska ◽  
Magdalena Laban ◽  
Dominika Drzewiecka ◽  
Agnieszka Pękala-Safińska ◽  
...  
Keyword(s):  
Epidemiological Data ◽  
13C Nmr Spectroscopy ◽  
Freshwater Species ◽  
Fish Farms ◽  
1H And 13C Nmr ◽  
Aeromonas Veronii ◽  
Specific Polysaccharide ◽  
O Antigens ◽  
Unique Composition

In the present work, we performed immunochemical studies of LPS, especially the O-specific polysaccharide (O-PS) of Aeromonas veronii bv. sobria strain K133, which was isolated from the kidney of carp (Cyprinus carpio L.) during an outbreak of motile aeromonad infection/motile aeromonad septicemia (MAI/MAS) on a Polish fish farm. The structural characterization of the O-PS, which was obtained by mild acid degradation of the LPS, was performed with chemical methods, MALDI-TOF mass spectrometry, and 1H and 13C NMR spectroscopy. It was revealed that the O-PS has a unique composition of a linear tetrasaccharide repeating unit and contains a rarely occurring sugar 2,4-diamino-2,4,6-trideoxy-D-glucose (bacillosamine), which may determine the specificity of the serogroup. Western blotting and ELISA confirmed that A. veronii bv. sobria strain K133 belongs to the new serogroup PGO1, which is one of the most commonly represented immunotypes among carp and trout isolates of Aeromonas sp. in Polish aquacultures. Considering the increase in the MAI/MAS incidences and their impact on freshwater species, also with economic importance, and in the absence of an effective immunoprophylaxis, studies of the Aeromonas O-antigens are relevant in the light of epidemiological data and monitoring emergent pathogens representing unknown antigenic variants and serotypes.

scholarly journals Characterization of Virulence Properties of Aeromonas veronii Isolated from Diseased Gibel Carp (Carassius gibelio)

2016 ◽  
Vol 17 (4) ◽  
pp. 496 ◽  
Author(s):  
Jingjing Sun ◽  
Xiaojun Zhang ◽  
Xiaojian Gao ◽  
Qun Jiang ◽  
Yi Wen ◽  
...  
Keyword(s):  
Gibel Carp ◽  
Aeromonas Veronii ◽  
Carassius Gibelio ◽  
Virulence Properties

scholarly journals Lactobacillus plantarum (VR1) isolated from an Ayurvedic medicine (Kutajarista) ameliorates in vitro cellular damage caused by Aeromonas veronii

2011 ◽  
Vol 11 (1) ◽  
pp. 152 ◽  
Author(s):  
Himanshu Kumar ◽  
Ashraf Y Rangrez ◽  
Kannayakanahalli M Dayananda ◽  
Ashwini N Atre ◽  
Milind S Patole ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
Cellular Damage ◽  
Ayurvedic Medicine ◽  
Aeromonas Veronii

Antibacterial prophylaxis and molecular docking studies of ketone and ester compounds isolated from Cyperus rotundus L. against Aeromonas veronii

2021 ◽  
Author(s):  
Nabanita Chakraborty ◽  
Basanta Kumar Das ◽  
Archan Kanti Das ◽  
Ranjan Kumar Manna ◽  
Hirak Jyoti Chakraborty ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Cyperus Rotundus ◽  
Antibacterial Prophylaxis ◽  
Molecular Docking Studies ◽  
Aeromonas Veronii
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