Field study indicating susceptibility differences between salmonid species and their lineages to proliferative kidney disease

2020 ◽  
Vol 43 (10) ◽  
pp. 1201-1211
Author(s):  
Eva Syrová ◽  
Miroslava Palíková ◽  
Jan Mendel ◽  
Veronika Seidlová ◽  
Ivana Papežíková ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Field Study ◽  
Proliferative Kidney Disease ◽  
Salmonid Species

Proliferative kidney disease of salmonid fish

1993 ◽  
Vol 3 ◽  
pp. 277-290 ◽  
Author(s):  
R.P. Hedrick ◽  
E. MacConnell ◽  
P. de Kinkelin
Keyword(s):  
Kidney Disease ◽  
Salmonid Fish ◽  
Proliferative Kidney Disease

Proliferative kidney disease and Sphaerospora oncorhynchi in wild-caught salmonids from the Puntledge River system, Vancouver Island, British Columbia

1995 ◽  
Vol 52 (S1) ◽  
pp. 13-17 ◽  
Author(s):  
M.L. Kent ◽  
M. Higgins ◽  
D.J. Whitaker ◽  
H. Yokoyama
Keyword(s):  
British Columbia ◽  
Kidney Disease ◽  
Chinook Salmon ◽  
Sockeye Salmon ◽  
Natural Infection ◽  
Vancouver Island ◽  
Renal Tubules ◽  
Kokanee Salmon ◽  
Proliferative Kidney Disease ◽  
Sexually Mature

Proliferative kidney disease (PKD), caused by the PKX myxosporean, was observed in kokanee salmon (non-anadromous sockeye salmon) (Oncorhynchus nerka) and chinook salmon (O. tshawytscha) collected from the Puntledge River, Vancouver Island, British Columbia in July 1993. This is the first report of a natural infection of PKX in either captive or wild sockeye salmon. All 14 underyearling kokanee salmon and the one underyearling chinook salmon exhibited numerous PKX organisms and associated chronic inflammation in the renal interstitium. Thirty-eight percent of sexually mature kokanee salmon collected in the autumn of 1993 from Comox Lake (which drains into the Puntledge River) were infected with Sphaerospora oncorhynchi, Kent, Whitaker and Margolis, 1993 in the renal tubules, while immature cutthroat trout (O. clarki) and coho salmon (O. kisutch) from the same collection did not exhibit myxosporean spores in the kidney. The kidneys of threespine stickleback (Gasterosteus aculeatus) and prickly sculpin (Cottus asper) collected from the Puntledge River during the summer were all infected with a Myxobilatus sp., but no organisms suggestive of PKX or Sphaerospora were observed. This study further supports the hypothesis that PKX is a developmental stage of S. oncorhynchi, which may sporulate only in sexually mature salmonids.

scholarly journals Transcriptome profiling of posterior kidney of brown trout, Salmo trutta, during proliferative kidney disease

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Arun Sudhagar ◽  
Reinhard Ertl ◽  
Gokhlesh Kumar ◽  
Mansour El-Matbouli
Keyword(s):  
Immune System ◽  
Kidney Disease ◽  
Differentially Expressed Genes ◽  
Brown Trout ◽  
Salmo Trutta ◽  
Differentially Expressed ◽  
Rna Seq ◽  
Proliferative Kidney Disease ◽  
Immune System Process ◽  
Upregulated Genes

Abstract Background Tetracapsuloides bryosalmonae is a myxozoan parasite which causes economically important and emerging proliferative kidney disease (PKD) in salmonids. Brown trout, Salmo trutta is a native fish species of Europe, which acts as asymptomatic carriers for T. bryosalmonae. There is only limited information on the molecular mechanism involved in the kidney of brown trout during T. bryosalmonae development. We employed RNA sequencing (RNA-seq) to investigate the global transcriptome changes in the posterior kidney of brown trout during T. bryosalmonae development. Methods Brown trout were exposed to the spores of T. bryosalmonae and posterior kidneys were collected from both exposed and unexposed control fish. cDNA libraries were prepared from the posterior kidney and sequenced. Bioinformatics analysis was performed using standard pipeline of quality control, reference mapping, differential expression analysis, gene ontology, and pathway analysis. Quantitative real time PCR was performed to validate the transcriptional regulation of differentially expressed genes, and their correlation with RNA-seq data was statistically analyzed. Results Transcriptome analysis identified 1169 differentially expressed genes in the posterior kidney of brown trout, out of which 864 genes (74%) were upregulated and 305 genes (26%) were downregulated. The upregulated genes were associated with the regulation of immune system process, vesicle-mediated transport, leucocyte activation, and transport, whereas the downregulated genes were associated with endopeptidase regulatory activity, phosphatidylcholine biosynthetic process, connective tissue development, and collagen catabolic process. Conclusion To our knowledge, this is the first RNA-seq based transcriptome study performed in the posterior kidney of brown trout during active T. bryosalmonae development. Most of the upregulated genes were associated with the immune system process, whereas the downregulated genes were associated with other metabolic functions. The findings of this study provide insights on the immune responses mounted by the brown trout on the developing parasite, and the host molecular machineries modulated by the parasite for its successful multiplication and release.

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