High‐intensity interval training along with spirulina algae consumption and caloric restriction ameliorated the Nrf1/Tfam/Mgmt and ATP5A1 pathway in the heart tissue of obese rats

2022 ◽  
Author(s):  
Mahboobeh Yousefian ◽  
Farzaneh Taghian ◽  
Gholamreza Sharifi ◽  
Seyed Ali Hosseini
Keyword(s):  
Caloric Restriction ◽  
High Intensity ◽  
Interval Training ◽  
Heart Tissue ◽  
High Intensity Interval Training ◽  
Obese Rats ◽  
High Intensity Interval

scholarly journals The Effect of Six Weeks of High Intensity Interval Training on eNOS and PGC-1α Gene Expression in the Heart Tissue of Male Obese Rats

2020 ◽  
Vol 12 (2) ◽  
Author(s):  
Behnoush Ghadery ◽  
Farshad Ghazalian ◽  
Seyed Ali Hosseini ◽  
Hossein Abed Natanzy ◽  
Alireza Shamsoddini
Keyword(s):  
Gene Expression ◽  
High Intensity ◽  
Interval Training ◽  
Heart Tissue ◽  
Male Rats ◽  
High Intensity Interval Training ◽  
Expression Levels ◽  
Obese Rats ◽  
High Intensity Interval ◽  
Gene Expression Levels

Background: Nowadays, obesity can affect heart function and induced atherosclerosis, high blood pressure, and heart arrhythmia, which has become a major problem for global health. Objectives: The present study aimed to review the effect of six weeks of high-intensity interval training (HIIT) on gene expression levels of PGC-1α and eNOS in the heart tissue of obese male rats. Methods: In this experimental study, 14 high-fat diet (HFD)-induced obese rats were divided into two groups of control and training. Also, 7 rats were placed in a non-obese control group to investigate the effects of obesity on research variables. During six weeks, rats in the training group performed HIIT three days per week. After six weeks, all rats were sacrificed, and their heart tissue was removed to measure the PGC-1α and eNOS gene expression. We used one-way ANOVA with Tukey’s post hoc tests (P ≤ 0.05) for statistical analysis. Results: HFD significantly decreased PGC-1α (P = 0.04) and eNOS (P = 0.001) gene expression, but HIIT significantly increased PGC-1α (P = 001) and eNOS (P = 0.001) gene expression. Conclusions: HIIT seems to improve cardiac gene expression levels of PGC-1α and eNOS of male obese rats.

scholarly journals Effect of 8 weeks high-intensity interval training (HIIT) with and without caloric restriction on gene expression of myocardial Bax and Bcl2 in mice

2021 ◽  
Vol 43 (1) ◽  
pp. 124-133
Author(s):  
Mohammadreza Zarali ◽  
Zaher Etemad ◽  
Kamal Azizbeigi ◽  
Pouran Karimi
Keyword(s):  
Gene Expression ◽  
Exercise Training ◽  
Caloric Restriction ◽  
High Intensity ◽  
Interval Training ◽  
Training Group ◽  
Control Group ◽  
High Intensity Interval Training ◽  
Interval Exercise ◽  
High Intensity Interval

Background: Apoptosis is the physiological cell death that in natural conditions leads to the elimination of old, damaged, waste, and harmful cells. The aim of this study was the effect of eight weeks of high-intensity interval training (HIIT) with and without caloric restriction on gene expression of myocardial Bax and Bcl2 in mice. Methods: Present study was an experimental multi-group design with a control group conducted on 30 two-month old male mice. Subjects were divided into five homogenous groups including base control, control, caloric restriction, interval exercise training, and caloric restriction + interval exercise training. Training groups participated in interval exercise training five sessions per week for 8 weeks. The level of gene expression of myocardial Bax and Bcl2 was evaluated by real-time PCR. Data were analyzed using the one-way ANOVA at the level of (P<0.05). Results: The results showed that the training group had a significant increase in gene expression of myocardial Bcl2 in comparison with caloric restriction + exercise training (P<0.05) and a significant decrease in gene expression of myocardial Bax compared to the caloric restriction group (P<0.05). Also, exercise training and exercise training + caloric restriction significantly increased the gene expression of myocardial Bcl2 and significantly decreased Bax/Bcl2 ratio compared to caloric restriction, base control, and control (P< 0.05). Conclusion: It seems that high-intensity interval training without caloric restriction would provide a suitable environment for increasing the integrity of the mitochondrial membrane of myocardial cells and possibly apoptosis.

scholarly journals Effect of 8 Weeks of High Intensity Interval Training (HIIT) With and Without Calorie Restriction on Gene Expression of Caspase-3 and Caspase-9 Proteins in Male Rats

2020 ◽  
Vol 23 (3) ◽  
pp. 300-313
Author(s):  
Mohammadreza Zarali ◽  
◽  
Zaher Etemad ◽  
Kamal Azizbeigi ◽  
Pouran Karimi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Exercise Training ◽  
Caloric Restriction ◽  
High Intensity ◽  
Caspase 3 ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Interval Exercise ◽  
High Intensity Interval ◽  
And Control

Background and Aim Apoptosis or programmed death is active biological process and reversible that the balance between growth and cell death in various tissues, particularly myocardial tissue is essential role. The aim of this study was the effect of 8 weeks High Intensity Interval Training (HIIT) with and without food restriction on gene expression of Caspase 3 and 9 in rats. Methods & Materials: This study was experimental multi group design with control group which conducted on 30 rats with two months old male. Subjects were divided in to five homogenous groups including base control, control, caloric restriction, interval exercise training and caloric restriction+interval exercise training. Training groups five sessions in weeks were participated in interval exercise training for 8 weeks. The level of gene expression of the proteins Caspase 3 and 9 was evaluated by Real Time-PCR. Dates were analyzed using the 1-way ANOVA at the level of (P<0.05). Ethical Considerations: The protocol of this study was approved by the Medical Committee of Sanandaj University of Medical Sciences (Code: IR.MYK.REC.1397.5022). Results: The results showed that the training group had a significant decrease in gene expression of Caspase 3 in comparison with caloric restriction+exercise training (P<0.05). Also, exercise training and exercise training+caloric restriction significantly decrease in the gene expression of Caspase 9 compared to caloric restriction, base control and control (P<0.05) and significantly decrease in the gene expression of Caspase 3 compared to base control and control (P<0.05). Conclusion: According to the results, it seems that high intensity interval training with and without calorie restriction provides the necessary adaptations to inhibit or stop apoptosis induced by aerobic exercise. 

scholarly journals The Effect of High Intensity Interval Training and Herb Supplement on Heart IGF-1 Concentration in Male Rat

2018 ◽  
Vol 3 (1) ◽  
pp. 13-17
Author(s):  
Mohamad Ali Pirani ◽  
Maghsoud Peeri ◽  
Mohamad Ali Azarbayjani
Keyword(s):  
High Intensity ◽  
Training Session ◽  
Interval Training ◽  
Heart Tissue ◽  
Flaxseed Oil ◽  
Male Rats ◽  
Male Rat ◽  
High Intensity Interval Training ◽  
Training Groups ◽  
High Intensity Interval

Abstract Objectives: The objective of the present study was to determine the effect of 10 weeks of high intensity interval training and flaxseed oil supplement on heart IGF-1 concentration in male rats. Materials and methods: 20 adult male Wistar rats were randomly divided into saline, saline–training, supplementation, and supplementation–training groups. The training groups performed training (10 weeks, five sessions per week, 90–95% VO2 max) on a rodent treadmill. The supplementation groups also received flaxseed oil supplement (30 mg/kg). The rats were sacrificed five days after the last training session. The heart tissue was collected, and sent to the laboratory for evaluation. Results: Training increased the concentration of the heart IGF-1 (P=0.01). The concentration of heart IGF-1 was higher in the flaxseed oil-supplemented groups than the saline-treated groups. (P=0.003). The interaction between training and supplementation also led to a increase in heart IGF-1 concentration (P=0.001). Conclusion: The increase of heart IGF-1 after training and consumption suggest that training and flaxseed oil can help to improve cardiac function.

Effect of High-Intensity Interval Training with Eryngium Campestre on Lipid Profile and Glycemic Indices in High-Fat Diet-Induced Obese Rats

2020 ◽  
Vol 24 (2) ◽  
Author(s):  
Behnoush Ghadery ◽  
Farshad Ghazalian ◽  
Seyed Ali Hosseini ◽  
Hossein Abed Natanzy ◽  
Alireza Shamsoddini
Keyword(s):  
Lipid Profile ◽  
High Intensity ◽  
High Fat Diet ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Fat ◽  
Glucose Levels ◽  
Obese Rats ◽  
Glycemic Indices ◽  
High Intensity Interval

Background: Obesity is a multi-factorial physical disorder that results in high serum lipid levels and glycemic disorders. On the other hand, regular exercise and administration of Eryngium Campestre (EC) have glucose and lipid-lowering effects. Objectives: The present study aimed to review the effect of high-intensity interval training (HIIT) with EC on lipid profile and glycemic indices in high-fat diet (HFD)-induced obese rats. Methods: Twenty-four obese rats were divided into four groups, including: (1) control, (2) HIIT, (3) EC, and (4) HIIT+EC. To investigate the effect of obesity on research variables, six rats were assigned to a healthy control group. During six weeks, groups 2 and 4 received HIIT three days per week, and groups 3 and 4 received 30 mg/kg EC by gavage. Data were analyzed using the Shapiro-Wilk test and one-way ANOVA with Tukey’s post hoc test (P ≤ 0.05). Results: Obesity significantly increased cholesterol (Cho), triglyceride (TG), insulin, and glucose levels (P ≤ 0.05). However, HIIT significantly decreased Cho, TG, insulin, and glucose levels (P ≤ 0.05), and EC significantly decreased Cho, TG, low-density lipoprotein (LDL), insulin, and glucose levels (P ≤ 0.05). Besides, HIIT+EC significantly decreased LDL and insulin (P ≤ 0.05). HIIT+EC could decrease LDL more than did HIIT (P ≤ 0.05). Conclusions: Although HIIT and EC alone improved the lipid profile and glycemic indices in obese rats, HIIT combined with EC had greater effects on the decrease of LDL compared to HIIT.

High-Intensity Interval Training and Hypoglycemia Minimization in Adults with Type 1 Diabetes (HIIT HYPO T1D Study)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 743-P
Author(s):  
ANGELA S. LEE ◽  
KIMBERLEY L. WAY ◽  
NATHAN A. JOHNSON ◽  
STEPHEN M. TWIGG
Keyword(s):  
Type 1 Diabetes ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Intensity Interval
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