Quantitative phosphoproteomics to resolve the cellular responses to octanoic acid in rotenone exposed zebrafish

2021 ◽  
Author(s):  
Mustafa Gani Sürmen ◽  
Saime Sürmen ◽  
Derya Cansız ◽  
İsmail Ünal ◽  
Ünsal Veli Üstündağ ◽  
...  
Keyword(s):  
Octanoic Acid ◽  
Cellular Responses ◽  
Quantitative Phosphoproteomics

scholarly journals Deciphering MET‐dependent modulation of global cellular responses to DNA damage by quantitative phosphoproteomics

2020 ◽  
Vol 14 (6) ◽  
pp. 1185-1206
Author(s):  
Ariel Bensimon ◽  
Jonas P. Koch ◽  
Paola Francica ◽  
Selina M. Roth ◽  
Rahel Riedo ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cellular Responses ◽  
Quantitative Phosphoproteomics

The Response of Testis Cells to Low Dose X-Irradiation

1981 ◽  
Vol 39 ◽  
pp. 542-543
Author(s):  
D. E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
Joann Stevenson ◽  
S. Black
Keyword(s):  
Electron Microscopy ◽  
Stem Cell ◽  
Light Microscopy ◽  
Dose Level ◽  
Cross Sections ◽  
Low Dose ◽  
Light And Electron Microscopy ◽  
Cellular Responses ◽  
Post Irradiation ◽  
X Irradiation

The response of spermatogonial cells to X-irradiation is well documented. It has been shown that there is a radiation resistent stem cell (As) which, after irradiation, replenishes the seminiferous epithelium. Most investigations in this area have dealt with radiation dosages of 100R or more. This study was undertaken to observe cellular responses at doses less than 100R of X-irradiation utilizing a system in which the tissue can be used for light and electron microscopy.Brown B6D2F1 mice aged 16 weeks were exposed to X-irradiation (225KeV; 15mA; filter 0.35 Cu; 50-60 R/min). Four mice were irradiated at each dose level between 1 and 100 rads. Testes were removed 3 days post-irradiation, fixed, and embedded. Sections were cut at 2 microns for light microscopy. After staining, surviving spermatogonia were identified and counted in tubule cross sections. The surviving fraction of spermatogonia compared to control, S/S0, was plotted against dose to give the curve shown in Fig. 1.

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