Coffee consumption revealed sex differences in host endogenous metabolism and gut microbiota in healthy adults

2020 ◽  
Vol 44 (12) ◽  
Author(s):  
Chun Wie Chong ◽  
Lai Chun Wong ◽  
Cindy S. J. Teh ◽  
Nor Hadiani Ismail ◽  
Pei Qi Chan ◽  
...  
Keyword(s):  
Sex Differences ◽  
Gut Microbiota ◽  
Coffee Consumption ◽  
Healthy Adults ◽  
Endogenous Metabolism

scholarly journals Sex differences in the phylum‐level human gut microbiota composition

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Alexander Koliada ◽  
Vladislav Moseiko ◽  
Mariana Romanenko ◽  
Oleh Lushchak ◽  
Nadiia Kryzhanovska ◽  
...  
Keyword(s):  
Sex Differences ◽  
Gut Microbiota ◽  
Age Groups ◽  
Microbiota Composition ◽  
Human Gut ◽  
Cross Sectional ◽  
Total N ◽  
Human Gut Microbiota ◽  
Gut Microbiota Composition

Abstract Background Evidence was previously provided for sex-related differences in the human gut microbiota composition, and sex-specific discrepancy in hormonal profiles was proposed as a main determinant of these differences. On the basis of these findings, the assumption was made on the role of microbiota in the sexual dimorphism of human diseases. To date, sex differences in fecal microbiota were demonstrated primarily at lower taxonomic levels, whereas phylum-level differences between sexes were reported in few studies only. In the present population-based cross-sectional research, sex differences in the phylum-level human gut microbiota composition were identified in a large (total n = 2301) sample of relatively healthy individuals from Ukraine. Results Relative abundances of Firmicutes and Actinobacteria, as determined by qRT-PCR, were found to be significantly increased, while that of Bacteroidetes was significantly decreased in females compared to males. The Firmicutes to Bacteroidetes (F/B) ratio was significantly increased in females compared to males. Females had 31 % higher odds of having F/B ratio more than 1 than males. This trend was evident in all age groups. The difference between sexes was even more pronounced in the elder individuals (50+): in this age group, female participants had 56 % higher odds of having F/B ratio > 1 than the male ones. Conclusions In conclusion, sex-specific differences in the phylum-level intestinal microbiota composition were observed in the Ukraine population. The F/B ratio was significantly increased in females compared to males. Further investigation is needed to draw strong conclusions regarding the mechanistic basis for sex-specific differences in the gut microbiota composition and regarding the role of these differences in the initiation and progression of human chronic diseases.

Recovery of gut microbiota of healthy adults following antibiotic exposure

2018 ◽  
Vol 3 (11) ◽  
pp. 1255-1265 ◽  
Author(s):  
Albert Palleja ◽  
Kristian H. Mikkelsen ◽  
Sofia K. Forslund ◽  
Alireza Kashani ◽  
Kristine H. Allin ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Healthy Adults ◽  
Antibiotic Exposure

scholarly journals Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis

2018 ◽  
Vol 107 (6) ◽  
pp. 965-983 ◽  
Author(s):  
Daniel So ◽  
Kevin Whelan ◽  
Megan Rossi ◽  
Mark Morrison ◽  
Gerald Holtmann ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gut Microbiota ◽  
Dietary Fiber ◽  
Meta Analysis ◽  
Healthy Adults ◽  
Microbiota Composition ◽  
Gut Microbiota Composition

scholarly journals Four-Week Fermented Dairy Beverage Consumption Impacts Gut Microbiota and Improves Relational Memory

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1194-1194
Author(s):  
Corinne Cannavale ◽  
Annemarie Krug ◽  
Hannah Holscher ◽  
Naiman Khan
Keyword(s):  
Gut Microbiota ◽  
Healthy Adults ◽  
Enzyme Linked Immunosorbent Assay ◽  
Relational Memory ◽  
Microbiota Composition ◽  
Depression And Anxiety ◽  
Symptoms Of Depression ◽  
Fermented Dairy ◽  
The Impact ◽  
Lactobacillus Spp

Abstract Objectives Converging evidence suggests probiotic supplementation can reduce cognitive and metabolic concerns for persons with gastrointestinal disorders. However, in healthy populations the impact of probiotics on these outcomes is lacking. Thus, we aimed to determine whether symptoms of depression and anxiety, memory function, cortisol concentrations, and gut microbiota composition are altered by consumption of a fermented dairy beverage containing probiotic microorganisms in healthy adults. Methods Adults (25–45 yrs, N = 26) free of physician diagnosed gastrointestinal and mental illness were enrolled in a single-blind, randomized crossover trial. Participants completed testing prior to and after 4-week consumption, with a 2–4 week washout between treatments of kefir, a dairy-based fermented beverage containing 25–30 billion colony forming units of live and active kefir cultures (including 3 Bifidobacterium spp., 6 Lactobacillus spp., Streptococcus Diacetylacti., Luconostoc Cremoris, and Staccharomyces Florentinus) or isocaloric, non-fermented dairy-based control beverage. Hippocampal-dependent relational memory was assessed using a spatial reconstruction task. Symptoms of depression and anxiety were assessed using the depression anxiety and stress subscale (DASS). Pooled 24-hour urine samples were analyzed using an enzyme-linked immunosorbent assay to determine urinary-free cortisol (UFC) concentrations. Fecal microbiota composition was assessed using 16 s rDNA sequencing. Results Post-test logistic regression analysis revealed an increase in the number of participants with Lactobacillus spp. present (b = 3.00, P < 0.01) after consumption of kefir. Two-by-two repeated measure ANOVA displayed that the treatment improved performance on two metrics of relational memory (F[1, 25] = 4.54, P = 0.043, F[1, 25] = 5.50, P = 0.027). UFC and DASS scores were not significantly changed by either arm of the intervention. Conclusions These results reveal that kefir consumption increases the presence of probiotic microorganisms in the gut and improves relational memory in healthy adults. The impact of fermented dairy beverages containing probiotic microorganisms in healthy populations should be studied at a larger scale to better elucidate these outcomes. Funding Sources USDA National Institute of Food and Agriculture.

Sex Differences in Striatal Dopamine Release in Healthy Adults

2006 ◽  
Vol 59 (10) ◽  
pp. 966-974 ◽  
Author(s):  
Cynthia A. Munro ◽  
Mary E. McCaul ◽  
Dean F. Wong ◽  
Lynn M. Oswald ◽  
Yun Zhou ◽  
...  
Keyword(s):  
Sex Differences ◽  
Dopamine Release ◽  
Healthy Adults ◽  
Striatal Dopamine ◽  
Striatal Dopamine Release

Impact of coffee consumption on the gut microbiota: A human volunteer study

2009 ◽  
Vol 130 (2) ◽  
pp. 117-121 ◽  
Author(s):  
Muriel Jaquet ◽  
Isabelle Rochat ◽  
Julie Moulin ◽  
Christophe Cavin ◽  
Rodrigo Bibiloni
Keyword(s):  
Gut Microbiota ◽  
Coffee Consumption ◽  
Human Volunteer ◽  
Volunteer Study

Consuming decaffeinated coffee with milk and sugar added before a high-glycaemic index meal improves postprandial glycaemic and insulinaemic responses in healthy adults

2020 ◽  
Vol 124 (8) ◽  
pp. 785-796
Author(s):  
Tommy H. T. Wong ◽  
Jennifer M. F. Wan ◽  
Iris M. Y. Tse ◽  
W. H. Sit ◽  
Jimmy C. Y. Louie
Keyword(s):  
Glucose Metabolism ◽  
Coffee Consumption ◽  
Postprandial Glucose ◽  
Glycaemic Index ◽  
Healthy Adults ◽  
Plain Water ◽  
Positive Effects ◽  
Different Types ◽  
Decaffeinated Coffee ◽  
Glucagon Like Peptide 1

AbstractThe present study aimed to compare the effects of drinking different types of coffee before a high-glycaemic index (GI) meal on postprandial glucose metabolism and to assess the effects of adding milk and sugar into coffee. In this randomised, crossover, acute feeding study, apparently healthy adults (n 21) consumed the test drink followed by a high-GI meal in each session. Different types of coffee (espresso, instant, boiled and decaffeinated, all with milk and sugar) and plain water were tested in separate sessions, while a subset of the participants (n 10) completed extra sessions using black coffees. Postprandial levels of glucose, insulin, active glucagon-like peptide 1 (GLP-1) and nitrotyrosine between different test drinks were compared using linear mixed models. Results showed that only preloading decaffeinated coffee with milk and sugar led to significantly lower glucose incremental AUC (iAUC; 14 % lower, P = 0·001) than water. Preloading black coffees led to greater postprandial glucose iAUC than preloading coffees with milk and sugar added (12–35 % smaller, P < 0·05 for all coffee types). Active GLP-1 and nitrotyrosine levels were not significantly different between test drinks. To conclude, preloading decaffeinated coffee with milk and sugar led to a blunted postprandial glycaemic response after a subsequent high-GI meal, while adding milk and sugar into coffee could mitigate the impairment effect of black coffee towards postprandial glucose responses. These findings may partly explain the positive effects of coffee consumption on glucose metabolism.

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