Novel antihypertensive action of rutin is mediated via inhibition of angiotensin converting enzyme/mineralocorticoid receptor/angiotensin 2 type 1 receptor (ATR1) signaling pathways in uninephrectomized hypertensive rats

2020 ◽  
Vol 44 (12) ◽  
Author(s):  
Ademola Adetokunbo Oyagbemi ◽  
Foluso Bolawaye Bolaji‐Alabi ◽  
Temitayo Olabisi Ajibade ◽  
Olumuyiwa Abiola Adejumobi ◽  
Olumide Samuel Ajani ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Signaling Pathways ◽  
Mineralocorticoid Receptor ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Antihypertensive Action

scholarly journals Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: Novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats

2021 ◽  
Author(s):  
Himanshu Sankrityayan ◽  
Ajinath Kale ◽  
Anil Bhanudas Gaikwad
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Endoplasmic Reticulum Stress ◽  
Angiotensin Converting Enzyme ◽  
Signaling Pathways ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2

Persistent hyperglycemia in type 1 diabetes triggers numerous signaling pathways, which may prove deleterious to the endothelium. Since hyperglycemia damages the endothelial layer via multiple signaling pathways, including enhanced oxidative stress, downregulation of angiotensin-converting enzyme2 signaling, and exacerbation of endoplasmic reticulum stress, etc.; hence it becomes difficult to prevent the injury using monotherapy. Thus, the present study was conceived to evaluate the combined effect of endoplasmic reticulum stress inhibition along with angiotensin-converting enzyme-2 activation, two major contributors to hyperglycemia-induced endothelial dysfunction, in preventing endothelial dysfunction associated with type 1 diabetes. Streptozotocin-induced diabetic animals were treated with either diminazene aceturate (5 mg kg-day-1, p.o.) or tauroursodeoxycholic acid, sodium salt (200 mg kg- day-1 i.p.), or both for four weeks. Endothelial dysfunction was evaluated using vasoreactivity assay, where acetylcholine-induced relaxation was assessed in phenylephrine pre-contracted rings. Combination therapy significantly improved vascular relaxation when compared to diabetic control as well as monotherapy. Restoration of nitrite levels along with prevention of collagen led to improved vasodilatation. Moreover, there was an overall reduction in aortic oxidative stress. We conclude that by simultaneously inhibiting ER stress and activating angiotensin-converting enzyme-2 deleterious effects of hyperglycemia on endothelium were significantly alleviated. This could serve as a novel strategy for the prevention of endothelial dysfunction.

Cardiomyocyte Apoptosis and Cardiac Angiotensin-Converting Enzyme in Spontaneously Hypertensive Rats

Hypertension ◽  
1997 ◽  
Vol 30 (5) ◽  
pp. 1029-1034 ◽  
Author(s):  
Javier Díez ◽  
Angel Panizo ◽  
Marta Hernández ◽  
Francisco Vega ◽  
Iosu Sola ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Spontaneously Hypertensive Rats ◽  
Cardiomyocyte Apoptosis ◽  
Converting Enzyme ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
Sign in / Sign up

Export Citation Format

Share Document