Black tea and curcumin synergistically mitigate the hepatotoxicity and nephropathic changes induced by chronic exposure to aflatoxin‐B1 in Sprague–Dawley rats

2020 ◽  
Vol 44 (9) ◽  
Author(s):  
Haitham I. El‐Mekkawy ◽  
Mohammed A. Al‐Kahtani ◽  
Ali A. Shati ◽  
Mohammed A. Alshehri ◽  
Amin A. Al‐Doaiss ◽  
...  
Keyword(s):  
Aflatoxin B1 ◽  
Chronic Exposure ◽  
Black Tea ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Chronic exposure of Sprague-Dawley rats to 20 kHz triangular magnetic fields

2010 ◽  
Vol 86 (5) ◽  
pp. 384-389 ◽  
Author(s):  
Hae-June Lee ◽  
Youn-Myoung Gimm ◽  
Hyung-Do Choi ◽  
Nam Kim ◽  
Sung-Ho Kim ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Chronic Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Protective effect of cyanidin 3-O-β-d-glucoside on ochratoxin A-mediated damage in the rat

2007 ◽  
Vol 98 (5) ◽  
pp. 937-943 ◽  
Author(s):  
Claudia Di Giacomo ◽  
Rosaria Acquaviva ◽  
Andrea Piva ◽  
Valeria Sorrenti ◽  
Luca Vanella ◽  
...  
Keyword(s):  
Ochratoxin A ◽  
Chronic Exposure ◽  
Control Diet ◽  
Lipid Hydroperoxide ◽  
Diet Group ◽  
Control Group ◽  
Thiol Groups ◽  
Sprague Dawley ◽  
Commercial Diet ◽  
Sprague Dawley Rats

The aim of the present study was to verify whether the oral administration of cyanidin 3-O-β-d-glucoside (C3G) might counteract damage induced by chronic exposure (28 d) to ochratoxin A (OTA) in rats and if its effect may be mediated by haeme oxygenase-1 (HO-1). Forty male Sprague–Dawley rats, individually caged, were divided into four groups of ten animals. A control group received a commercial diet, group C3G received the control diet supplemented with C3G (1 g/kg feed), group OTA received the control diet supplemented with 200 parts per billion of OTA, and group OTA+C3G received the OTA group diet supplemented with C3G (1 g/kg feed). After 4 weeks of treatment animals were killed and the liver, kidneys and brain of each rat were collected and homogenised to evaluate non-proteic thiol groups (RSH), lipid hydroperoxide (LOOH) levels, HO-1 expression and DNA fragmentation. Rats of the OTA group showed a significant (P < 0·001) decrease in RSH content of kidney and liver and a significant (P < 0·001) increase of LOOH in all the examined tissues compared with the control group. In the OTA+C3G group both RSH content and LOOH levels were similar to those observed in the control group, demonstrating that C3G was able to counteract the effects of OTA. A significant (P < 0·001) induction of HO-1 was evident in kidney and liver of both OTA and C3G groups. DNA damage occurred in all the examined tissues of the OTA group, whereas C3G was able to prevent it. The present study confirmed that the effects of OTA are mediated by oxidative stress and demonstrated that C3G efficiently counteracted deleterious effects of OTA because of its antioxidant and HO-1-inducing properties.

scholarly journals Urinary excretion of aflatoxin M1 after administration of aflatoxin B1 in sucrose- or starch-rich diets

1978 ◽  
Vol 40 (2) ◽  
pp. 397-401 ◽  
Author(s):  
A. Wise ◽  
M. Suzangar ◽  
M. Messripour ◽  
J. Mohammadi
Keyword(s):  
Urinary Excretion ◽  
Aflatoxin B1 ◽  
Aflatoxin M1 ◽  
Sprague Dawley ◽  
Drug Metabolizing Enzyme ◽  
Sprague Dawley Rats ◽  
Metabolizing Enzyme ◽  
Aflatoxin B

1. Male Sprague–Dawley rats were given 630 g/kg sucrose or starch with 2 mg/kg aflatoxin B1 for periods of 75, 145 and 200 d, and the 24 h urinary excretion of aflatoxin M1 was measured.2. Less aflatoxin M1 was excreted by the rats fed on the sucrose-rich diet compared to those fed on the starch-rich diet. This difference was especially marked when expressed per g metabolizing tissue.3. It is concluded that sucrose probably decreases the activity of aflatoxin B1 metabolism in a similar way to its previously found effect on the drug-metabolizing enzyme.

Combined effects of the mycotoxins aflatoxin B1 and cyclopiazonic acid on Sprague-Dawley rats

1987 ◽  
Vol 25 (11) ◽  
pp. 837-842 ◽  
Author(s):  
R.E. Morrissey ◽  
W.P. Norred ◽  
D.M. Hinton ◽  
R.J. Cole ◽  
J.W. Dorner
Keyword(s):  
Aflatoxin B1 ◽  
Cyclopiazonic Acid ◽  
Combined Effects ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Evaluation of reproductive and developmental toxicities of Pu-erh black tea (Camellia sinensis var. assamica) extract in Sprague Dawley rats

2013 ◽  
Vol 148 (1) ◽  
pp. 190-198 ◽  
Author(s):  
Di Wang ◽  
Jie Meng ◽  
Hui Gao ◽  
Kunlong Xu ◽  
Rong Xiao ◽  
...  
Keyword(s):  
Camellia Sinensis ◽  
Black Tea ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Effect of Chronic Exposure to Dexamethasone on Rocuronium-induced Neuromuscular Blockade and Sugammadex Reversal: an in Vivo Study on Rats

2021 ◽  
Author(s):  
Ha Yeon Park ◽  
Heyran Choi ◽  
Yong Beom Kim ◽  
Seok Kyeong Oh ◽  
Taehoon Kim ◽  
...  
Keyword(s):  
Neuromuscular Blockade ◽  
Chronic Exposure ◽  
Recovery Time ◽  
Medical Center ◽  
Control Group ◽  
Sprague Dawley ◽  
Dexamethasone Group ◽  
Sprague Dawley Rats ◽  
Train Of Four

Abstract Background: Chronic exposure to glucocorticoids is associated with resistance to nondepolarising neuromuscular blocking agents. Therefore, we hypothesised that sugammadex-induced recovery in subjects with chronic exposure to dexamethasone was faster than that in subjects without dexamethasone exposure. Objective: To evaluate the recovery profile of rocuronium-induced neuromuscular blockade after sugammadex administration in rats. Design: An in vivo study on rats.Setting: Asan Institute for Life Sciences, Asan Medical Center, Korea, from April 2017 to October 2017.Animals: Thirty-six male Sprague-Dawley rats.Intervention: Sprague–Dawley rats were allocated to three groups (dexamethasone group, control group, and pair-fed group) for the in vivo study. Dexamethasone group received daily intraperitoneal injections of dexamethasone 500 μg kg-1 or 0.9% saline for 15 days. On the sixteenth day, 3.5 mg kg-1 of rocuronium was administered to achieve complete neuromuscular blockade. Main outcome measures: The recovery time to a train-of-four ratio Results: There were no significant differences in the recovery time to train-of-four ratio to 0.9 among the groups (P = 0.531). The time to second twitch of train-of-four recovery that indicated the duration of rocuronium-induced neuromuscular blockade was significantly shorter in Group D than in Groups C and P (P = 0.001). Conclusion: As previously reported, resistance to rocuronium was observed in rats with chronic exposure to dexamethasone. However, the neuromuscular recovery time after sugammadex administration was not significantly different between groups.

Acute and subchronic oral toxicities of Pu-erh black tea extract in Sprague–Dawley rats

2011 ◽  
Vol 134 (1) ◽  
pp. 156-164 ◽  
Author(s):  
Di Wang ◽  
Kunlong Xu ◽  
Ying Zhong ◽  
Xiao Luo ◽  
Rong Xiao ◽  
...  
Keyword(s):  
Black Tea ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Black Tea Extract ◽  
Tea Extract
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