Modulatory effects of moringa ( Moringa oleifera L.) leaves infested with African mistletoe ( Tapinanthus bangwensis L.) on the antioxidant, antidiabetic, and neurochemical indices in high sucrose diet‐induced diabetic‐like phenotype in fruit flies ( Drosophila melanogaster M.)

2020 ◽  
Author(s):  
Olubukola H. Oyeniran ◽  
Adedayo O. Ademiluyi ◽  
Ganiyu Oboh
Keyword(s):  
Drosophila Melanogaster ◽  
Moringa Oleifera ◽  
Fruit Flies ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

scholarly journals Effect of Chlorella vulgaris extract on high sucrose diet-induced diabetes in Drosophila melanogaster

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Mohamad Agus Salim ◽  
Muhammad Subandi ◽  
Yeni Yuniarti
Keyword(s):  
Drosophila Melanogaster ◽  
Chlorella Vulgaris ◽  
Metabolic Disorders ◽  
Single Treatment ◽  
Wild Type ◽  
Negative Effects ◽  
The Third ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
High Sucrose

Microalgae Chlorella vulgaris is a microscopic green algae that has known potential as a source of food and medicine (functional food). However, the pharmacological capacity of this microalgae species against disease due to metabolic disorders is still not understood. Thus, this study aims to evaluate the effect of C. vulgaris extract on animal models of Drosophila melanogaster (Drosophila) which are fed high-sucrose diet (HSD). Wild type Drosophila was used in this study for 7 days of observation. Drosophila was divided into four groups consisting of the first group that was not treated as a control. The second group was treated with HSD (30%), the third group was treated with C. vulgaris extract (120 g/L) and the fourth group was treated with double treatment (HSD and C. vulgaris extract). The parameters observed included fecundity, hatchability, hemolymph glucose and triglyceride levels. The results showed that the extract of C. vulgaris was able to reduce the negative effects of giving HSD. The single treatment of C. vulgaris extract and double treatment between C. vulgaris extract and HSD significantly decreased levels of hemolymph glucose, triglycerides of Drosophila, while the parameters of fecundity and hatchability were significantly increased when compared to Drosophila which only received HSD treatment. The conclusion of this study is that C. vulgaris extract can be used as an antihyperglycemic agent which requires further study to prove the results that have been obtained.

High-sucrose diet induces diabetic-like phenotypes and oxidative stress in Drosophila melanogaster : Protective role of Syzygium cumini and Bauhinia forficata

2017 ◽  
Vol 89 ◽  
pp. 605-616 ◽  
Author(s):  
Assis Ecker ◽  
Thallita Karla Silva do Nascimento Gonzaga ◽  
Rodrigo Lopes Seeger ◽  
Matheus Mulling dos Santos ◽  
Julia Sepel Loreto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Protective Role ◽  
Syzygium Cumini ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
Bauhinia Forficata ◽  
High Sucrose ◽  
And Oxidative Stress

Hepatic Transcriptomic Signature of High-Sucrose Diet in Nonobese Model of Metabolic Syndrome and Prediabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1723-P
Author(s):  
IRENA MARKOVÁ ◽  
MARTINA HÜTTL ◽  
HANA MALINSKA ◽  
ONDREJ SEDA ◽  
LUDMILA KAZDOVA
Keyword(s):  
Metabolic Syndrome ◽  
Sucrose Diet ◽  
Transcriptomic Signature ◽  
High Sucrose Diet ◽  
High Sucrose

Motor learning impairment in rats under a high sucrose diet

2021 ◽  
Vol 234 ◽  
pp. 113384
Author(s):  
Nayely Flores-Fuentes ◽  
Carolina Hernandez-Cruz ◽  
Karina Bermeo ◽  
Antonio Barajas-Martinez ◽  
Valeria Nayely Hernandez-Serratos ◽  
...  
Keyword(s):  
Motor Learning ◽  
Sucrose Diet ◽  
High Sucrose Diet ◽  
Learning Impairment ◽  
High Sucrose

scholarly journals Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Sang Hyuk Lee ◽  
Eunjoo Cho ◽  
Sung-Eun Yoon ◽  
Youngjoon Kim ◽  
Eun Young Kim
Keyword(s):  
Locomotor Behavior ◽  
Sensory Inputs ◽  
Sucrose Diet ◽  
High Nutrient ◽  
Intracellular Ca ◽  
High Sucrose Diet ◽  
Locomotor Activities ◽  
Locomotor Behaviors ◽  
High Sucrose ◽  
Over Time

AbstractMetabolism influences locomotor behaviors, but the understanding of neural curcuit control for that is limited. Under standard light-dark cycles, Drosophila exhibits bimodal morning (M) and evening (E) locomotor activities that are controlled by clock neurons. Here, we showed that a high-nutrient diet progressively extended M activity but not E activity. Drosophila tachykinin (DTk) and Tachykinin-like receptor at 86C (TkR86C)-mediated signaling was required for the extension of M activity. DTk neurons were anatomically and functionally connected to the posterior dorsal neuron 1s (DN1ps) in the clock neuronal network. The activation of DTk neurons reduced intracellular Ca2+ levels in DN1ps suggesting an inhibitory connection. The contacts between DN1ps and DTk neurons increased gradually over time in flies fed a high-sucrose diet, consistent with the locomotor behavior. DN1ps have been implicated in integrating environmental sensory inputs (e.g., light and temperature) to control daily locomotor behavior. This study revealed that DN1ps also coordinated nutrient information through DTk signaling to shape daily locomotor behavior.

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