Uricostatic and uricosuric effect of grapefruit juice in potassium oxonate‐induced hyperuricemic mice

2020 ◽  
Vol 44 (7) ◽  
Author(s):  
Arshad Mehmood ◽  
Liang Zhao ◽  
Muhammad Ishaq ◽  
Muhammad Usman ◽  
Oumeddour Dounya Zad ◽  
...  
Keyword(s):  
Grapefruit Juice ◽  
Uricosuric Effect ◽  
Potassium Oxonate

Teriflunomide‐associated urolithiasis: a new adverse reaction explained by its uricosuric effect

2021 ◽  
Author(s):  
Bérenger Largeau ◽  
Frédéric Béra ◽  
Jacques Vannier ◽  
Annie‐Pierre Jonville‐Béra
Keyword(s):  
Adverse Reaction ◽  
Uricosuric Effect

One pot clarification and debittering of grapefruit juice using co-immobilized enzymes@chitosanMNPs

2020 ◽  
Author(s):  
Mayur R. Ladole ◽  
Pravin B. Pokale ◽  
Vrushali R. Varude ◽  
Prasad G. Belokar ◽  
Aniruddha B. Pandit
Keyword(s):  
Grapefruit Juice ◽  
Immobilized Enzymes ◽  
One Pot

Furocoumarin Kinetics in Plasma and Urine of Healthy Adults Following Consumption of Grapefruit (Citrus paradisi Macf.) and Grapefruit Juice

2017 ◽  
Vol 65 (14) ◽  
pp. 3006-3012 ◽  
Author(s):  
Melissa M. Melough ◽  
Terrence M. Vance ◽  
Sang Gil Lee ◽  
Anthony A. Provatas ◽  
Christopher Perkins ◽  
...  
Keyword(s):  
Grapefruit Juice ◽  
Healthy Adults ◽  
Citrus Paradisi

scholarly journals Grapefruit Juice Suppresses Azoxymethane-induced Colon Aberrant Crypt Formation and Induces Antioxidant Capacity in Mice

2013 ◽  
Vol 14 (11) ◽  
pp. 6851-6856 ◽  
Author(s):  
Eduardo Madrigal-Bujaidar ◽  
Laura Martino Roaro ◽  
Karol Garcia-Aguirre ◽  
Sandra Garcia-Medina ◽  
Isela Alvarez-Gonzalez
Keyword(s):  
Antioxidant Capacity ◽  
Grapefruit Juice

Effect and Mechanism of Total Saponin of Dioscorea on Animal Experimental Hyperuricemia

2006 ◽  
Vol 34 (01) ◽  
pp. 77-85 ◽  
Author(s):  
Guang-Liang Chen ◽  
Wei Wei ◽  
Shu-Yun Xu
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Serum Uric Acid Level ◽  
Urate Oxidase ◽  
Uric Acid Concentration ◽  
Total Saponin ◽  
Test Kit ◽  
Serum Uric Acid Concentration ◽  
Potassium Oxonate

In this study, we investigated the effects and mechanisms of Total Saponin of Dioscorea (TSD) on animal experimental hyperuricemia. Mouse and rat hyperuricemic models were made by orally administering yeast extract paste once a day (30 and 20 g/kg, respectively), for 7 days. Yeast would disturb normal purine metabolism by increasing xanthine oxidase (XOD) activity and generating large quantities of uric acid. This model is similar to human hyperuricemia, which is induced by high-protein diets, due to a purine and nucleic acid metabolic disturbance. Another mouse hyperuricemia model was generated by intraperitoneal injection once with uric acid 250 mg/kg or potassium oxonate 300 mg/kg. Potassium oxonate, a urate oxidase inhibitor, can raise the serum uric acid level by inhibiting the decomposition of uric acid. Likewise, injecting uric acid can also increase serum uric acid concentration. The concentration of uric acid in serum or urine was detected by the phosphotungstic acid method, and the activity of XOD was assayed by a test kit. The results showed that TSD (240, 120 and 60 mg/kg, ig) could significantly lower the level of serum uric acid in hyperuricemic mice. TSD (120 and 60 mg/kg, ig) could also lower the level of serum uric acid in hyperuricemic rats, reduce the activity of XOD in the serum and liver of hyperuricemic rats, and increase the level of urine uric acid concentration as well as 24-hour total uric acid excretion. In conclusion, TSD possesses a potent anti-hyperuricemic effect on hyperuricemic animals, and the mechanism may be relevant in accelerating the excretion and decreasing the production of uric acid.

scholarly journals Impact of citrus soft drinks relative to grapefruit juice on ciclosporin disposition

2006 ◽  
Vol 62 (4) ◽  
pp. 485-491 ◽  
Author(s):  
Ute I. Schwarz ◽  
Philip E. Johnston ◽  
David G. Bailey ◽  
Richard B. Kim ◽  
Gail Mayo ◽  
...  
Keyword(s):  
Grapefruit Juice ◽  
Soft Drinks
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