Flower extracts from Paeonia decomposita and Paeonia ostii inhibit melanin synthesis via cAMP‐CREB‐associated melanogenesis signaling pathways in murine B16 melanoma cells

2019 ◽  
Vol 43 (4) ◽  
pp. e12777 ◽  
Author(s):  
Lixia Guo ◽  
Zhongyi Yin ◽  
Li Wen ◽  
Juan Xin ◽  
Xue Gao ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Melanin Synthesis ◽  
B16 Melanoma Cells

scholarly journals Elucidation of Melanogenesis-Associated Signaling Pathways Regulated by Argan Press Cake in B16 Melanoma Cells

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2697
Author(s):  
Thouria Bourhim ◽  
Myra O. Villareal ◽  
Chemseddoha Gadhi ◽  
Hiroko Isoda
Keyword(s):  
Signaling Pathways ◽  
Press Cake ◽  
Global Gene Expression ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Dependent Manner ◽  
Melanin Biosynthesis ◽  
B16 Melanoma Cells ◽  
Pigmentary Disorders ◽  
Argan Oil

The beneficial effect on health of argan oil is recognized worldwide. We have previously reported that the cake that remains after argan oil extraction (argan press-cake or APC) inhibits melanogenesis in B16 melanoma cells in a time-dependent manner without cytotoxicity. In this study, the global gene expression profile of B16 melanoma cells treated with APC extract was determined in order to gain an understanding of the possible mechanisms of action of APC. The results suggest that APC extract inhibits melanin biosynthesis by down-regulating microphthalmia-associated transcription factor (Mitf) and its downstream signaling pathway through JNK signaling activation, and the inhibition of Wnt/β-catenin and cAMP/PKA signaling pathways. APC extract also prevented the transport of melanosomes by down-regulating Rab27a expression. These results suggest that APC may be an important natural skin whitening product and pharmacological agent used for clinical treatment of pigmentary disorders.

scholarly journals Constituents of Cryptotaenia japonica Inhibit Melanogenesis via CREB- and MAPK-Associated Signaling Pathways in Murine B16 Melanoma Cells

Molecules ◽  
2016 ◽  
Vol 21 (10) ◽  
pp. 1296 ◽  
Author(s):  
Zuh-Kyung Seong ◽  
Sung-Yoon Lee ◽  
Amrit Poudel ◽  
Sei-Ryang Oh ◽  
Hyeong-Kyu Lee
Keyword(s):  
Signaling Pathways ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells

scholarly journals A New 2-Imino-1,3-thiazoline Derivative, KHG22394, Inhibits Melanin Synthesis in Mouse B16 Melanoma Cells

2007 ◽  
Vol 30 (1) ◽  
pp. 180-183 ◽  
Author(s):  
Dong-Seok Kim ◽  
Yun-Mi Jeong ◽  
Ik-Kyu Park ◽  
Hoh-Gyu Hahn ◽  
Hyun-Kyung Lee ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
B16 Melanoma ◽  
Melanin Synthesis ◽  
B16 Melanoma Cells

Aglycone of Rh4Inhibits Melanin Synthesis in B16 Melanoma Cells: Possible Involvement of the Protein Kinase A Pathway

2013 ◽  
Vol 77 (1) ◽  
pp. 119-125 ◽  
Author(s):  
Yun-Mi JEONG ◽  
Won Keun OH ◽  
Tien Lam TRAN ◽  
Wang-Kyun KIM ◽  
Sang Hyun SUNG ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Melanin Synthesis ◽  
B16 Melanoma Cells ◽  
Kinase A

scholarly journals An Isoxazole Chalcone Derivative Enhances Melanogenesis in B16 Melanoma Cells via the Akt/GSK3β/β-Catenin Signaling Pathways

Molecules ◽  
2017 ◽  
Vol 22 (12) ◽  
pp. 2077 ◽  
Author(s):  
Li Yin ◽  
Chao Niu ◽  
Li-xin Liao ◽  
Jun Dou ◽  
Maidina Habasi ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
B16 Melanoma Cells ◽  
Chalcone Derivative

PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells

2012 ◽  
Vol 113 (8) ◽  
pp. 2738-2743 ◽  
Author(s):  
Xiaodong Zhang ◽  
Guirui Yan ◽  
Jun Ji ◽  
Jingwei Wu ◽  
Xiaoyun Sun ◽  
...  
Keyword(s):  
Pde5 Inhibitor ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Melanin Synthesis ◽  
B16 Melanoma Cells
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