Commercially available non-nutritive sweeteners modulate the antioxidant status of type 2 diabetic rats

2019 ◽  
Vol 43 (3) ◽  
pp. e12775 ◽  
Author(s):  
Nomcebo Mchunu ◽  
Chika Ifeanyi Chukwuma ◽  
Mohammed Auwal Ibrahim ◽  
Olajumoke A. Oyebode ◽  
Siphiwe Ndumiso Dlamini ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Diabetic Rats ◽  
Type 2 Diabetic

scholarly journals Effects of White Rice, Brown Rice and Germinated Brown Rice on Antioxidant Status of Type 2 Diabetic Rats

2012 ◽  
Vol 13 (12) ◽  
pp. 12952-12969 ◽  
Author(s):  
Mustapha Umar Imam ◽  
Siti Nor Asma Musa ◽  
Nur Hanisah Azmi ◽  
Maznah Ismail
Keyword(s):  
Antioxidant Status ◽  
Brown Rice ◽  
Diabetic Rats ◽  
Germinated Brown Rice ◽  
White Rice ◽  
Type 2 Diabetic

scholarly journals Centella asiatica enhances hepatic antioxidant status and regulates hepatic inflammatory cytokines in type 2 diabetic rats

2017 ◽  
Vol 55 (1) ◽  
pp. 1671-1678 ◽  
Author(s):  
Ayodeji B. Oyenihi ◽  
Novel N. Chegou ◽  
Oluwafemi O. Oguntibeju ◽  
Bubuya Masola
Keyword(s):  
Inflammatory Cytokines ◽  
Antioxidant Status ◽  
Centella Asiatica ◽  
Diabetic Rats ◽  
Type 2 Diabetic

scholarly journals Metformin/Donepezil combination modulates brain antioxidant status and hippocampal endoplasmic reticulum stress in type 2 diabetic rats

2020 ◽  
Vol 19 (1) ◽  
pp. 499-510 ◽  
Author(s):  
Tajudeen Olabisi Obafemi ◽  
Oluwaseun R. Olasehinde ◽  
Oyindamola A. Olaoye ◽  
Kikelomo F. Jaiyesimi ◽  
Funmilayo D. Adewumi ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Antioxidant Status ◽  
Diabetic Rats ◽  
Type 2 Diabetic

Study on the Effect of Cerium Oxide Nanocubes on Full-Thickness Cutaneous Wound Healing of Type 2 Diabetic Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cerium Oxide ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Type 2 Diabetic

Neuroprotection of Maslinic Acid, a Novel Glycogen Phos-phorylase Inhibitor, in Type 2 Diabetic Rats

2010 ◽  
Vol 8 (4) ◽  
pp. 293-297 ◽  
Author(s):  
Teng GUAN ◽  
Yi-Song QIAN ◽  
Meng-Hao HUANG ◽  
Long-Fei HUANG ◽  
Xu-Zhen TANG ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Maslinic Acid ◽  
Type 2 Diabetic

Blockade of Renin Angiotensin System Ameliorates the Cardiac Arrhythmias and Sympathetic Neural Remodeling in Hearts of Type 2 DM Rat Model

2020 ◽  
Vol 20 (3) ◽  
pp. 464-478 ◽  
Author(s):  
Yomna M. Yehya ◽  
Abdelaziz M. Hussein ◽  
Khaled Ezam ◽  
Elsayed A. Eid ◽  
Eman M. Ibrahim ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiac Arrhythmias ◽  
Sympathetic Nerve ◽  
Renin Angiotensin System ◽  
Diabetic Rats ◽  
Angiotensin System ◽  
Type 2 Dm ◽  
Type 2 Diabetic ◽  
Diabetes Induction

Objectives:: The present study was designed to investigate the effects of renin angiotensin system (RAS) blockade on cardiac arrhythmias and sympathetic nerve remodelling in heart tissues of type 2 diabetic rats. Methods:: Thirty-two male Sprague Dawley rats were randomly allocated into 4 equal groups; a) normal control group: normal rats, b) DM group; after type 2 diabetes induction, rats received 2ml oral saline daily for 4 weeks, c) DM+ ACEi: after type 2 diabetes induction, rats were treated with enalapril (10 mg/kg, orally for 4 weeks) and d) DM+ ARBs: after type 2 diabetes induction, rats were treated with losartan (30 mg/kg, orally for 4 weeks). Results:: In type 2 diabetic rats, the results demonstrated significant prolongation in Q-T interval and elevation of blood sugar, HOMA-IR index, TC, TGs, LDL, serum CK-MB, myocardial damage, myocardial MDA, myocardial norepinephrine and tyrosine hydroxylase (TH) density with significant reduction in serum HDL, serum insulin and myocardial GSH and CAT. On the other hand, blockade of RAS at the level of either ACE by enalapril or angiotensin (Ag) receptors by losartan resulted in significant improvement in ECG parameters (Q-T), cardiac enzymes (CK-MB), cardiac morphology, myocardial oxidative stress (low MDA, high CAT and GSH) and myocardial TH density. Conclusions:: RAS plays a role in the cardiac sympathetic nerve sprouting and cardiac arrhythmias induced by type 2 DM and its blockade might have a cardioprotective effect via attenuation of sympathetic nerve fibres remodelling, myocardial norepinephrine contents and oxidative stress.

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