A novel powder formulation of coconut inflorescence sap inhibits alcoholic liver damage by modulating inflammatory markers, extracellular matrix metalloproteinase, and oxidative stress

2018 ◽  
Vol 42 (5) ◽  
pp. e12543 ◽  
Author(s):  
Svenia P. Jose ◽  
Ratheesh Mohanan ◽  
Sandya S ◽  
Asha S ◽  
Krishnakumar IM
Keyword(s):  
Oxidative Stress ◽  
Extracellular Matrix ◽  
Matrix Metalloproteinase ◽  
Liver Damage ◽  
Inflammatory Markers ◽  
Powder Formulation ◽  
And Oxidative Stress

Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis

2021 ◽  
Vol 12 (5) ◽  
pp. 2323-2334
Author(s):  
Shihong Zheng ◽  
Peichang Cao ◽  
Zequn Yin ◽  
Xuerui Wang ◽  
Yuanli Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Liver Fibrosis ◽  
Liver Damage ◽  
Liver Diseases ◽  
Potential Drug ◽  
Abnormal Lipid Metabolism ◽  
And Oxidative Stress

Apigenin prevented the DDC-induced abnormal lipid metabolism, liver damage and liver fibrosis by reducing inflammation and oxidative stress. Apigenin might be a potential drug for the treatment of cholestatic liver diseases.

scholarly journals Effects of MP Polyethylene Microparticles on Microbiome and Inflammatory Response of Larval Zebrafish

Toxics ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 55
Author(s):  
Nicholas Kurchaba ◽  
Bryan J. Cassone ◽  
Caleb Northam ◽  
Bernadette F. Ardelli ◽  
Christophe M. R. LeMoine
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Markers ◽  
Production Cost ◽  
Resting Metabolic Rate ◽  
Metabolic Disturbances ◽  
Microbiome Composition ◽  
Larval Zebrafish ◽  
Living Organisms ◽  
Stress Mediator ◽  
And Oxidative Stress

Plastic polymers have quickly become one of the most abundant materials on Earth due to their low production cost and high versatility. Unfortunately, some of the discarded plastic can make its way into the environment and become fragmented into smaller microscopic particles, termed secondary microplastics (MP). In addition, primary MP, purposely manufactured microscopic plastic particles, can also make their way into our environment via various routes. Owing to their size and resilience, these MP can then be easily ingested by living organisms. The effect of MP particles on living organisms is suspected to have negative implications, especially during early development. In this study, we examined the effects of polyethylene MP ingestion for four and ten days of exposure starting at 5 days post-fertilization (dpf). In particular, we examined the effects of polyethylene MP exposure on resting metabolic rate, on gene expression of several inflammatory and oxidative stress linked genes, and on microbiome composition between treatments. Overall, we found no evidence of broad metabolic disturbances or inflammatory markers in MP-exposed fish for either period of time. However, there was a significant increase in the oxidative stress mediator L-FABP that occurred at 15 dpf. Furthermore, the microbiome was disrupted by MP exposure, with evidence of an increased abundance of Bacteroidetes in MP fish, a combination frequently found in intestinal pathologies. Thus, it appears that acute polyethylene MP exposure can increase oxidative stress and dysbiosis, which may render the animal more susceptible to diseases.

scholarly journals Effect ofBifidobacterium lactisHN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome

2018 ◽  
Vol 120 (6) ◽  
pp. 645-652 ◽  
Author(s):  
Luciana J. Bernini ◽  
Andréa N. Colado Simão ◽  
Cínthia H. B. de Souza ◽  
Daniela F. Alfieri ◽  
Liliane G. Segura ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Inflammatory Markers ◽  
Healthy Subjects ◽  
Antioxidant Defenses ◽  
Beneficial Effects ◽  
The Metabolic Syndrome ◽  
Inflammatory State ◽  
Baseline Values ◽  
And Oxidative Stress

AbstractBeneficial effects of probiotics have been reported on body weight, lipid and carbohydrate metabolism, inflammatory state and oxidative stress in healthy subjects and in many metabolic and inflammatory diseases. The aim of this study was to evaluate the effects ofBifidobacterium lactisHN019 on inflammatory state and nitro-oxidative stress in patients with and without the metabolic syndrome (MetS). The usual diets of the thirty-three subjects were supplemented with probiotic milk for 90 d. Inflammatory markers and oxidative measurements were performed. In relation to the baseline values, subjects in both groups showed a decrease in homocysteine (P=0·02 andP=0·03, respectively), hydroperoxides (P=0·02 andP=0·01, respectively) and IL-6 levels (P=0·02). Increases in adiponectin (P=0·04) and nitric oxide metabolites (NOx,P=0·001) levels were only seen in the group with the MetS in relation to the baseline values, whereas only the individuals without the MetS had increases in total radical-trapping antioxidant parameter levels (P=0·002). In conclusion,B. lactisHN019 have several beneficial effects on inflammatory and oxidative biomarkers in healthy subjects and the MetS patients. Patients with the MetS showed a specific improvement in adiponectin and NOx levels, whereas a specific favourable effect was shown in the antioxidant defenses in healthy subjects. If the results obtained in the present study are confirmed, supplementation of fermented milk with probiotics in healthy subjects and patients with the MetS must be further discussed.

scholarly journals Comparative effects of estrogen, raloxifene and tamoxifen on endothelial dysfunction, inflammatory markers and oxidative stress in ovariectomized rats

Life Sciences ◽  
2015 ◽  
Vol 124 ◽  
pp. 101-109 ◽  
Author(s):  
Aline Zandonadi Lamas ◽  
Izabela Facco Caliman ◽  
Polyana Lima Meireles Dalpiaz ◽  
Antônio Ferreira de Melo ◽  
Glaucia Rodrigues Abreu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Inflammatory Markers ◽  
Ovariectomized Rats ◽  
And Oxidative Stress

scholarly journals PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

2011 ◽  
Vol 31 (17) ◽  
pp. 3616-3629 ◽  
Author(s):  
A. Avivar-Valderas ◽  
E. Salas ◽  
E. Bobrovnikova-Marjon ◽  
J. A. Diehl ◽  
C. Nagi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Extracellular Matrix ◽  
Stress Responses ◽  
Oxidative Stress Responses ◽  
And Oxidative Stress

scholarly journals Antioxidant and hepatoprotective effects of the food seasoning curry leaves Murraya koenigii (L.) Spreng. (Rutaceae)

RSC Advances ◽  
2015 ◽  
Vol 5 (122) ◽  
pp. 100589-100597 ◽  
Author(s):  
Wan Yong Ho ◽  
Boon Kee Beh ◽  
Kian Lam Lim ◽  
Nurul Elyani Mohamad ◽  
Hamidah Mohd Yusof ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gallic Acid ◽  
Liver Damage ◽  
Water Extract ◽  
Leaf Water ◽  
Murraya Koenigii ◽  
Curry Leaves ◽  
Hepatoprotective Effects ◽  
And Oxidative Stress

The curry leaf water extract, which is rich in gallic acid, reversed paracetamol-induced liver damage in mice by reducing inflammation and oxidative stress.

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