Structural-features of food-derived bioactive peptides with anti-inflammatory activity: A brief review

2018 ◽  
Vol 43 (1) ◽  
pp. e12531 ◽  
Author(s):  
Snigdha Guha ◽  
Kaustav Majumder
Keyword(s):  
Bioactive Peptides ◽  
Structural Features ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Baijiu vinasse as a new source of bioactive peptides with antioxidant and anti-inflammatory activity

2021 ◽  
Vol 339 ◽  
pp. 128159
Author(s):  
Lin Peng ◽  
Xiaoyong Kong ◽  
Zongmin Wang ◽  
Aisikaer Ai-lati ◽  
Zhongwei Ji ◽  
...  
Keyword(s):  
Bioactive Peptides ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Anti-inflammatory activity of peptides derived from millet bran in vitro and in vivo

2022 ◽  
Author(s):  
Rong He ◽  
Mengting Liu ◽  
Zhipeng Zou ◽  
Mingjie Wang ◽  
Zhigao Wang ◽  
...  
Keyword(s):  
Bioactive Peptides ◽  
Bioactive Peptide ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Various food-derived bioactive peptides have been found with potential anti-inflammatory effects. Millet bran peptide is a food-derived bioactive peptide extracted from millet bran, a by-product of millet processing. In this...

Legume Proteins as a Promising Source of Anti-Inflammatory Peptides

2019 ◽  
Vol 20 (12) ◽  
pp. 1204-1217 ◽  
Author(s):  
Aline Reyes-Díaz ◽  
Carmen Lizette Del-Toro-Sánchez ◽  
José Carlos Rodríguez-Figueroa ◽  
Santiago Valdéz-Hurtado ◽  
Francisco Javier Wong-Corral ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Bioactive Peptides ◽  
Inflammatory Activity ◽  
In Vivo Studies ◽  
Cytokines And Chemokines ◽  
Legume Proteins ◽  
Anti Inflammatory ◽  
Promising Source

Legume proteins are precursors of bioactive components, such as peptides. In the present paper, different types of legume as sources of bioactive peptides and hydrolysates are considered and discussed based on their anti-inflammatory effect. Peptides with anti-inflammatory activity were included from in vitro and in vivo studies. Current strategies for obtaining bioactive peptides, as well as their structure and impact on health, were also reviewed. It was discovered that peptides derived from legume protein, mainly soybean and bean, can regulate several inflammatory markers, which include prostaglandin E2 (PGE2), nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX- 2), cytokines, and chemokines. So far, lunasin, VPY and γ-glutamyl peptides have been identified with anti-inflammatory activity but their mechanisms have not been fully elucidated. Furthermore, it is necessary to gather more information about hydrolysates containing peptides and single peptides with antiinflammatory activity. Considering the wide diversity, legume may be promising components to produce peptides efficient to ameliorate inflammatory disorders.

Synthesis and Evaluation of Substituted Aryl Thiazoles With Antioxidant Potential as Gastro-sparing Anti-inflammatory Agents

2020 ◽  
Vol 17 (12) ◽  
pp. 1566-1578
Author(s):  
Akhil Bansal ◽  
Alka Bali ◽  
Ajitesh Balaini
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Reducing Power ◽  
Structural Features ◽  
Inflammatory Activity ◽  
Standard Group ◽  
Standard Drug ◽  
Rat Paw Edema ◽  
Anti Inflammatory

Background: NSAIDs are used as first-line drugs for the treatment of various inflammatory disorders. Chronic use of NSAIDs is known to be associated with gastrointestinal and renal toxicity. Local generation of reactive oxygen species finally resulting in cellular apoptosis is one of the accepted mechanisms for NSAID-induced toxicity. Objective: The objective of the present study was to design and synthesize a series of 2-methane sulfonamido substituted arylthiazole derivatives by including structural features of combined antiulcer and anti-inflammatory activity utilizing as the structural core, thiazole nucleus with potential for antioxidant effect. Methods: Compounds were designed based on three dimensional and field similarity studies. The synthesized compounds were evaluated for their anti-inflammatory activity in carrageenan-induced rat paw edema model. Rofecoxib and indomethacin were taken as standard drugs for comparison. The in vitro antioxidant activity was assessed in potassium ferricyanide reducing power (PFRAP) assay employing ascorbic acid as the standard drug. Results: The compounds 6 and 7 showed good anti-inflammatory activity comparable to the standard group and were also non ulcerogenic at the test doses. Compounds 1-7 displayed varying degrees of reducing power in the PFRAP) assay and the methanesulphonamido derivatives 4-7 showed the highest antioxidant activity (EC50 values 3.7-5.1 μmol/ml vs ascorbic acid 7.4 μmol/ml). Theoretical ADME profiling of the compounds based on selected physicochemical properties showed excellent compliance with Lipinski’s rule. Conclusion: A series of compounds have been designed and synthesized having dual antioxidant and anti-inflammatory activity with activities comparable to standard drugs.

scholarly journals The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal Inflammation

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Wanying Zhu ◽  
Liying Ren ◽  
Li Zhang ◽  
Qinqin Qiao ◽  
Muhammad Zahid Farooq ◽  
...  
Keyword(s):  
Bioactive Peptides ◽  
Intestinal Inflammation ◽  
Janus Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Inflammatory Activity ◽  
Peptide Transporter ◽  
Food Protein ◽  
Anti Inflammatory ◽  
Chronic Intestinal Inflammation

Inflammation can cause various chronic diseases like inflammatory bowel diseases. Various food protein-derived bioactive peptides (BAPs) with anti-inflammatory activity have the potential to manage these diseases. The aim of this paper is to overview the mechanisms and the molecular targets of BAPs to exert anti-inflammatory activity. In this review, the in vitro and in vivo effects of BAPs on intestinal inflammation are highlighted. The mechanism, pathways, and future perspectives of BAPs as the potential sources of therapeutic treatments to alleviate intestinal inflammation are provided, including nuclear factor-κB, mitogen-activated protein kinase, Janus kinase-signal transducer and activator of transcription, and peptide transporter 1 (PepT1), finding that PepT1 and gut microbiota are the promising targets for BAPs to alleviate the intestinal inflammation. This review provides a comprehensive understanding of the role of dietary BAPs in attenuating inflammation and gives a novel direction in nutraceuticals for people or animals with intestinal inflammation.

Anti-platelet and anti-inflammatory activity of Plumbago zeylanicus (Pz), Phyllanthus emblica (Pe) and their combination

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
DA Uchil ◽  
SK Kamat ◽  
SS Menon ◽  
AM Scindia ◽  
GK Dang ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Phyllanthus Emblica ◽  
Anti Inflammatory

A new flavonol with anti-inflammatory activity from Boldoa purpurascens Cav.

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
DM González Mosquera ◽  
A Kilonda ◽  
S Toppet ◽  
F Compernolle ◽  
W Dehaen ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Anti Inflammatory

Isolation characterization and anti-inflammatory activity of Rhaphiostylis beninensis Planch. Ex Benth (Icacinaceae)

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
J Ofeimun ◽  
B Ayinde ◽  
I Igbe ◽  
MI Choudhary ◽  
I Husain ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Anti Inflammatory
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