Protective effect of dietary fiber from sweet potato (Ipomoea batatasL.) against lead-induced renal injury by inhibiting oxidative stress via AMPK/SIRT1/PGC1α signaling pathways

2018 ◽  
Vol 42 (3) ◽  
pp. e12513
Author(s):  
Yi Zhang ◽  
WenLong Gu ◽  
LiQin Duan ◽  
Hong Zhu ◽  
HongYun Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Signaling Pathways ◽  
Dietary Fiber ◽  
Sweet Potato ◽  
Renal Injury

scholarly journals Protective Effect of White-Skinned Sweet Potato (Ipomoea batatas L.) from Indonesia on Streptozotocin-Induced Oxidative Stress in Rats

2010 ◽  
Vol 20 (11) ◽  
pp. 1569-1576 ◽  
Author(s):  
Moch. Saiful Bachri ◽  
Hye-Won Jang ◽  
Jong-Won Choi ◽  
Jong-Ok Park
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Sweet Potato ◽  
Ipomoea Batatas

scholarly journals Protective Effect of Shikimic Acid against Cisplatin-Induced Renal Injury: In Vitro and In Vivo Studies

Plants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1681
Author(s):  
Jinkyung Lee ◽  
Quynh Nhu Nguyen ◽  
Jun Yeon Park ◽  
Sullim Lee ◽  
Gwi Seo Hwang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Cell Viability ◽  
Renal Injury ◽  
Shikimic Acid ◽  
Kidney Injury ◽  
In Vivo Studies ◽  
Artemisia Absinthium ◽  
Vitro Assay

Nephrotoxicity is a serious side effect of cisplatin, which is one of the most frequently used drugs for cancer treatment. This study aimed to assess the renoprotective effect of Artemisia absinthium extract and its bioactive compound (shikimic acid) against cisplatin-induced renal injury. An in vitro assay was performed in kidney tubular epithelial cells (LLC-PK1) with 50, 100, and 200 µg/mL A. absinthium extract and 25 and 50 µM shikimic acid, and cytotoxicity was induced by 25 µM cisplatin. BALB/c mice (6 weeks old) were injected with 16 mg/kg cisplatin once and orally administered 25 and 50 mg/kg shikimic acid daily for 4 days. The results showed that the A. absinthium extract reversed the decrease in renal cell viability induced by cisplatin, whereas it decreased the reactive oxidative stress accumulation and apoptosis in LLC-PK1 cells. Shikimic acid also reversed the effect on cell viability but decreased oxidative stress and apoptosis in renal cells compared with the levels in the cisplatin-treated group. Furthermore, shikimic acid protected against kidney injury in cisplatin-treated mice by reducing serum creatinine levels. The protective effect of shikimic acid against cisplatin-mediated kidney injury was confirmed by the recovery of histological kidney injury in cisplatin-treated mice. To the best of our knowledge, this study is the first report on the nephroprotective effect of A. absinthium extract and its mechanism of action against cisplatin-induced renal injury.

scholarly journals Protective Effect of Coptis chinensis Polysaccharide Against Renal Injury by Suppressing Oxidative Stress and Inflammation in Diabetic Rats

2019 ◽  
Vol 14 (9) ◽  
pp. 1934578X1986099
Author(s):  
Shuang Jiang ◽  
Yong Tang ◽  
Yang Bao ◽  
Xin Su ◽  
Kexin Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Renal Injury ◽  
Renal Tissue ◽  
Diabetic Rats ◽  
The Body ◽  
Antidiabetic Activity ◽  
Coptis Chinensis ◽  
Tyrosine Kinase 2 ◽  
Underlying Mechanisms

Our previous studies confirmed that Coptis chinensis polysaccharide (CCPW) had a good antidiabetic activity and could improve insulin resistance. However, whether CCPW has a protective effect against the renal injury caused by diabetes has not been reported. In this study, the protective effect of CCPW against the renal injury of diabetic rats and its underlying mechanisms were investigated. The results showed that in CCPW-treated groups, the body mass of rats increased significantly, while the ratio of kidney weight to body weight decreased significantly; the 24-hour urine protein and the serum BUN and serum creatinine (Scr) levels decreased significantly, and pathological changes of the renal tissue were improved; superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities in the renal tissue were significantly higher, and malondialdehyde (MDA) contents in the renal tissue, and tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), and hypersensitive c-reactive protein (hs-CRP) levels in the serum were significantly lower; the expressions of phosphorylated tyrosine kinase 2 (p-JAK2) and activators of transcription 3 (p-STAT3) decreased significantly. The results indicate that CCPW should have a protective effect against the renal injury in diabetic rats, which may be associated with its inhibition on oxidative stress and inflammation.

scholarly journals Protective effect of Boysenberry Juice on Ferric Nitrilotriacetate-induced Renal Injury in Mice

2021 ◽  
pp. 76-81
Author(s):  
Takashi Hashimoto ◽  
Maki Kiyota ◽  
Kazuki Kanazawa
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Protective Effect ◽  
Blood Urea Nitrogen ◽  
Renal Injury ◽  
Thiobarbituric Acid ◽  
Thiobarbituric Acid Reactive Substances ◽  
Urea Nitrogen ◽  
Ferric Nitrilotriacetate ◽  
Ad Libitum

Boysenberry (Rubus loganbaccus × baileyanus Britt.) is one of the popular berries in Western countries. In the present study, the effect of the boysenberry juice on ferric nitrilotriacetate (Fe-NTA)-induced renal injury was investigated. ICR mice (7 weeks old, male) were ad libitum administered boysenberry juice for 1 week, and were intraperitoneally injected Fe-NTA (5 mg Fe/kg body weight) as an oxidant to renal. The consumption of boysenberry juice suppressed the Fe-NTA-increased thiobarbituric acid reactive substances (TBARS) in kidney and blood urea nitrogen (BUN). These results indicate that the consumption of boysenberry juice reduces the risk of oxidative stress.

scholarly journals The Role of Ubiquitination and Sumoylation in Diabetic Nephropathy

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Chenlin Gao ◽  
Wei Huang ◽  
Keizo Kanasaki ◽  
Yong Xu
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Signaling Pathways ◽  
Renal Injury ◽  
Treatment Strategy ◽  
Microvascular Complication ◽  
Epigenetic Mechanism ◽  
Potential Treatment ◽  
Ubiquitin Proteasome

Diabetic nephropathy (DN) is a common and characteristic microvascular complication of diabetes; the mechanisms that cause DN have not been clarified, and the epigenetic mechanism was promised in the pathology of DN. Furthermore, ubiquitination and small ubiquitin-like modifier (SUMO) were involved in the progression of DN. MG132, as a ubiquitin proteasome, could improve renal injury by regulating several signaling pathways, such as NF-κB, TGF-β, Nrf2-oxidative stress, and MAPK. In this review, we summarize how ubiquitination and sumoylation may contribute to the pathology of DN, which may be a potential treatment strategy of DN.

scholarly journals Protective Effect of Sweet Potato Peel against Oxidative Stress in Hyperlipidemic Albino Rats

2019 ◽  
Vol 10 (05) ◽  
pp. 503-516
Author(s):  
Sami A Althwab ◽  
Hassan M. Mousa ◽  
Khaled M El-Zaha ◽  
A. M. Abdel Zaher
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Sweet Potato ◽  
Albino Rats ◽  
Potato Peel
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