Epigallocatechin Gallate and Caffeine Prevent DNA Adduct Formation and Interstrand Cross-Links Induced by Acrolein and Crotonaldehyde

2015 ◽  
Vol 39 (6) ◽  
pp. 725-732 ◽  
Author(s):  
Mingfu Wang ◽  
Wen Hao
Keyword(s):  
Epigallocatechin Gallate ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Interstrand Cross Links ◽  
Cross Links

Inhibitory Effects of (−)-Epigallocatechin Gallate on the Mutation, DNA Strand Cleavage, and DNA Adduct Formation by Heterocyclic Amines

2003 ◽  
Vol 51 (17) ◽  
pp. 5150-5153 ◽  
Author(s):  
Sakae Arimoto-Kobayashi ◽  
Naomi Inada ◽  
Yasuko Sato ◽  
Chitose Sugiyama ◽  
Keinosuke Okamoto ◽  
...  
Keyword(s):  
Epigallocatechin Gallate ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Heterocyclic Amines ◽  
Inhibitory Effects ◽  
Dna Strand

Electron microscopic study of the membrane glycoproteins in the rat kidney after cisplatin treatment

1989 ◽  
Vol 47 ◽  
pp. 912-913
Author(s):  
S.K. Aggarwal
Keyword(s):  
Alkaline Phosphatase ◽  
Rat Kidney ◽  
Light And Electron Microscopy ◽  
Kidney Tissue ◽  
Membrane Glycoproteins ◽  
Electron Microscopic ◽  
Before And After ◽  
Interstrand Cross Links ◽  
Cross Links

The proposed primary mechanism of action of the anticancer drug cisplatin (Cis-DDP) is through its interaction with DNA, mostly through DNA intrastrand cross-links or DNA interstrand cross-links. DNA repair mechanisms can circumvent this arrest thus permitting replication and transcription to proceed. Various membrane transport enzymes have also been demonstrated to be effected by cisplatin. Glycoprotein alkaline phosphatase was looked at in the proximal tubule cells before and after cisplatin both in vivo and in vitro for its inactivation or its removal from the membrane using light and electron microscopy.Outbred male Swiss Webster (Crl: (WI) BR) rats weighing 150-250g were given ip injections of cisplatin (7mg/kg). Animals were killed on day 3 and day 5. Thick slices (20-50.um) of kidney tissue from treated and untreated animals were fixed in 1% buffered glutaraldehyde and 1% formaldehyde (0.05 M cacodylate buffer, pH 7.3) for 30 min at 4°C. Alkaline phosphatase activity and carbohydrates were demonstrated according to methods described earlier.

Nitroreduction of 4-Nitropyrene Is Primarily Responsible for DNA Adduct Formation in the Mammary Gland of Female CD Rats

1999 ◽  
Vol 12 (2) ◽  
pp. 180-186 ◽  
Author(s):  
Young-Heum Chae ◽  
Ben-Yi Ji ◽  
Jyh-Ming Lin ◽  
Peter P. Fu ◽  
Bongsup P. Cho ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Adduct Formation ◽  
Dna Adduct

scholarly journals Ethanol and 4-methylpyrazole increase DNA adduct formation of furfuryl alcohol in FVB/N wild-type mice and in mice expressing human sulfotransferases 1A1/1A2

2016 ◽  
Vol 37 (3) ◽  
pp. 314-319 ◽  
Author(s):  
Benjamin Sachse ◽  
Walter Meinl ◽  
Hansruedi Glatt ◽  
Bernhard H. Monien
Keyword(s):  
Furfuryl Alcohol ◽  
Adduct Formation ◽  
Dna Adduct ◽  
Wild Type
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