The effects of 11‐ketotestosterone implants on transcript levels of gonadotropin receptors, and foxl2 and dmrt1 genes in the Previtellogenic ovary of cultured beluga ( Huso huso )

2020 ◽  
Vol 97 (2) ◽  
pp. 374-382
Author(s):  
Abdolali Rahdari ◽  
Majidreza Khoshkholgh ◽  
Mahtab Yarmohammadi ◽  
Maren Ortiz‐Zarragoitia ◽  
Pieter Mark Lokman ◽  
...  
Keyword(s):  
Huso Huso ◽  
Gonadotropin Receptors ◽  
Transcript Levels

Expression profiles of gonadotropin receptors during ovary development in the orange-spotted grouper (Epinephelus coioides)

2013 ◽  
Vol 19 (6) ◽  
pp. 915-922 ◽  
Author(s):  
Xuesong HU ◽  
Xiaochun LIU ◽  
Yong ZHANG ◽  
Shuisheng LI ◽  
Huapu CHEN ◽  
...  
Keyword(s):  
Expression Profiles ◽  
Ovary Development ◽  
Epinephelus Coioides ◽  
Gonadotropin Receptors

Influence of the serine amino acid on the viability and sperm fertility of the beluga (Huso huso)

Cryobiology ◽  
2020 ◽  
Vol 97 ◽  
pp. 286
Author(s):  
Konstantin Kovalev ◽  
Olga Dokina ◽  
Natalya Pronina
Keyword(s):  
Amino Acid ◽  
Huso Huso

scholarly journals Molecular Mechanisms of ZC3H12C/Reg-3 Biological Activity and Its Involvement in Psoriasis Pathology

2021 ◽  
Vol 22 (14) ◽  
pp. 7311
Author(s):  
Mateusz Wawro ◽  
Jakub Kochan ◽  
Weronika Sowinska ◽  
Aleksandra Solecka ◽  
Karolina Wawro ◽  
...  
Keyword(s):  
Family Member ◽  
Cellular Localization ◽  
Molecular Mechanisms ◽  
Inflammatory Diseases ◽  
Association Studies ◽  
Psoriasis Patient ◽  
Genome Wide Association Studies ◽  
Mrna Levels ◽  
Transcript Levels

The members of the ZC3H12/MCPIP/Regnase family of RNases have emerged as important regulators of inflammation. In contrast to Regnase-1, -2 and -4, a thorough characterization of Regnase-3 (Reg-3) has not yet been explored. Here we demonstrate that Reg-3 differs from other family members in terms of NYN/PIN domain features, cellular localization pattern and substrate specificity. Together with Reg-1, the most comprehensively characterized family member, Reg-3 shared IL-6, IER-3 and Reg-1 mRNAs, but not IL-1β mRNA, as substrates. In addition, Reg-3 was found to be the only family member which regulates transcript levels of TNF, a cytokine implicated in chronic inflammatory diseases including psoriasis. Previous meta-analysis of genome-wide association studies revealed Reg-3 to be among new psoriasis susceptibility loci. Here we demonstrate that Reg-3 transcript levels are increased in psoriasis patient skin tissue and in an experimental model of psoriasis, supporting the immunomodulatory role of Reg-3 in psoriasis, possibly through degradation of mRNA for TNF and other factors such as Reg-1. On the other hand, Reg-1 was found to destabilize Reg-3 transcripts, suggesting reciprocal regulation between Reg-3 and Reg-1 in the skin. We found that either Reg-1 or Reg-3 were expressed in human keratinocytes in vitro. However, in contrast to robustly upregulated Reg-1 mRNA levels, Reg-3 expression was not affected in the epidermis of psoriasis patients. Taken together, these data suggest that epidermal levels of Reg-3 are negatively regulated by Reg-1 in psoriasis, and that Reg-1 and Reg-3 are both involved in psoriasis pathophysiology through controlling, at least in part different transcripts.

scholarly journals Nucleotide-Binding Leucine-Rich Repeat Genes CsRSF1 and CsRSF2 Are Positive Modulators in the Cucumis sativus Defense Response to Sphaerotheca fuliginea

2021 ◽  
Vol 22 (8) ◽  
pp. 3986
Author(s):  
Xue Wang ◽  
Qiumin Chen ◽  
Jingnan Huang ◽  
Xiangnan Meng ◽  
Na Cui ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Defense Response ◽  
Nucleotide Binding ◽  
Plant Defense Response ◽  
Sphaerotheca Fuliginea ◽  
Leucine Rich Repeat ◽  
Transcript Levels ◽  
Yield And Quality ◽  
Leucine Rich Repeats ◽  
Exogenous Substances

Cucumber powdery mildew caused by Sphaerotheca fuliginea is a leaf disease that seriously affects cucumber’s yield and quality. This study aimed to report two nucleotide-binding site-leucine-rich repeats (NBS-LRR) genes CsRSF1 and CsRSF2, which participated in regulating the resistance of cucumber to S. fuliginea. The subcellular localization showed that the CsRSF1 protein was localized in the nucleus, cytoplasm, and cell membrane, while the CsRSF2 protein was localized in the cell membrane and cytoplasm. In addition, the transcript levels of CsRSF1 and CsRSF2 were different between resistant and susceptible cultivars after treatment with exogenous substances, such as abscisic acid (ABA), methyl jasmonate (MeJA), salicylic acid (SA), ethephon (ETH), gibberellin (GA) and hydrogen peroxide (H2O2). The expression analysis showed that the transcript levels of CsRSF1 and CsRSF2 were correlated with plant defense response against S. fuliginea. Moreover, the silencing of CsRSF1 and CsRSF2 impaired host resistance to S. fuliginea, but CsRSF1 and CsRSF2 overexpression improved resistance to S. fuliginea in cucumber. These results showed that CsRSF1 and CsRSF2 genes positively contributed to the resistance of cucumber to S. fuliginea. At the same time, CsRSF1 and CsRSF2 genes could also regulate the expression of defense-related genes. The findings of this study might help enhance the resistance of cucumber to S. fuliginea.

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