Molecular cloning, expression of, and regulation by thyroid-hormone receptor α A in the half-smooth tongue sole Cynoglossus semilaevis during metamorphosis

2016 ◽  
Vol 88 (5) ◽  
pp. 1693-1707 ◽  
Author(s):  
W. T. Zhang ◽  
K. Liu ◽  
J. S. Xiang ◽  
L. Y. Zhang ◽  
W. J. Liu ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Molecular Cloning ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Cynoglossus Semilaevis ◽  
Tongue Sole ◽  
Half Smooth Tongue Sole ◽  
Thyroid Hormone Receptor Α

scholarly journals 3,3′,5-Triiodothyroacetic acid (TRIAC) induces embryonic ζ-globin expression via thyroid hormone receptor α

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Huiqiao Chen ◽  
Zixuan Wang ◽  
Shanhe Yu ◽  
Xiao Han ◽  
Yun Deng ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Globin Gene ◽  
Erythroid Cells ◽  
Cell Disease ◽  
Potent Inducer ◽  
Thyroid Hormone Receptor Α

AbstractThe human ζ-globin gene (HBZ) is transcribed in primitive erythroid cells only during the embryonic stages of development. Reactivation of this embryonic globin synthesis would likely alleviate symptoms both in α-thalassemia and sickle-cell disease. However, the molecular mechanisms controlling ζ-globin expression have remained largely undefined. Moreover, the pharmacologic agent capable of inducing ζ-globin production is currently unavailable. Here, we show that TRIAC, a bioactive thyroid hormone metabolite, significantly induced ζ-globin gene expression during zebrafish embryogenesis. The induction of ζ-globin expression by TRIAC was also observed in human K562 erythroleukemia cell line and primary erythroid cells. Thyroid hormone receptor α (THRA) deficiency abolished the ζ-globin-inducing effect of TRIAC. Furthermore, THRA could directly bind to the distal enhancer regulatory element to regulate ζ-globin expression. Our study provides the first evidence that TRIAC acts as a potent inducer of ζ-globin expression, which might serve as a new potential therapeutic option for patients with severe α-thalassemia or sickle-cell disease.

scholarly journals Nuclear factors specifically favor thyroid hormone binding to c-ErbAα1 protein (thyroid hormone receptor α) over-expressed in E. coli

FEBS Letters ◽  
1995 ◽  
Vol 358 (2) ◽  
pp. 137-141 ◽  
Author(s):  
Malika Daadi ◽  
Christelle Lenoir ◽  
Alexandra Dace ◽  
Jeannine Bonne ◽  
Michèle Teboul ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Hormone Binding ◽  
E Coli ◽  
Nuclear Factors ◽  
Thyroid Hormone Receptor Α

scholarly journals Temperature Homeostasis in Transgenic Mice Lacking Thyroid Hormone Receptor-α Gene Products

Endocrinology ◽  
2005 ◽  
Vol 146 (7) ◽  
pp. 2872-2884 ◽  
Author(s):  
Husnia Marrif ◽  
Aria Schifman ◽  
Zaruhi Stepanyan ◽  
Marc-Antoine Gillis ◽  
Angelino Calderone ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Transgenic Mice ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Gene Products ◽  
Temperature Homeostasis ◽  
Thyroid Hormone Receptor Α

scholarly journals Elevated expression of thyroid hormone receptor α 2 (c-erb A-α2) in nasopharyngeal carcinoma*

2000 ◽  
Vol 83 (12) ◽  
pp. 1674-1680 ◽  
Author(s):  
J-W Lee ◽  
C-L Chen ◽  
B-T Juang ◽  
J-Y Chen ◽  
C-S Yang ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Nasopharyngeal Carcinoma ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Elevated Expression ◽  
Thyroid Hormone Receptor Α

scholarly journals Molecular cloning and expression analysis of the aqp1aa gene in half-smooth tongue sole (Cynoglossus semilaevis)

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0175033 ◽  
Author(s):  
Hua Guo ◽  
Min Wei ◽  
Yang Liu ◽  
Ying Zhu ◽  
Wenteng Xu ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Expression Analysis ◽  
Cynoglossus Semilaevis ◽  
Cloning And Expression ◽  
Tongue Sole ◽  
Half Smooth Tongue Sole

scholarly journals Activation of the thyroid hormone receptor α gene promoter by the orphan nuclear receptor ERRα

Oncogene ◽  
1998 ◽  
Vol 17 (19) ◽  
pp. 2429-2435 ◽  
Author(s):  
Jean-Marc Vanacker ◽  
Edith Bonnelye ◽  
Cateline Delmarre ◽  
Vincent Laudet
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptor ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Gene Promoter ◽  
Orphan Nuclear Receptor ◽  
Thyroid Hormone Receptor Α
Sign in / Sign up

Export Citation Format

Share Document