scholarly journals Diversification of HP1-like Chromo Domain Proteins inTetrahymena thermophila

2017 ◽  
Vol 65 (1) ◽  
pp. 104-116 ◽  
Author(s):  
Emily A. Wiley ◽  
Scott Horrell ◽  
Alyssa Yoshino ◽  
Cara C. Schornak ◽  
Claire Bagnani ◽  
...  
Keyword(s):  
Chromo Domain

scholarly journals Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3

2001 ◽  
Vol 20 (18) ◽  
pp. 5232-5241 ◽  
Author(s):  
Steven A. Jacobs ◽  
Sean D. Taverna ◽  
Yinong Zhang ◽  
Scott D. Briggs ◽  
Jinmei Li ◽  
...  
Keyword(s):  
Histone H3 ◽  
Chromo Domain ◽  
N Terminus

scholarly journals DNA-binding and chromatin localization properties of CHD1.

1995 ◽  
Vol 15 (5) ◽  
pp. 2745-2753 ◽  
Author(s):  
D G Stokes ◽  
R P Perry
Keyword(s):  
Dna Binding ◽  
Minor Groove ◽  
Binding Activity ◽  
Micrococcal Nuclease ◽  
Matrix Attachment Region ◽  
Centromeric Heterochromatin ◽  
Immunoglobulin Gene ◽  
Sequence Motifs ◽  
Chromo Domain ◽  
Dna Binding Activity

CHD1 is a novel DNA-binding protein that contains both a chromatin organization modifier (chromo) domain and a helicase/ATPase domain. We show here that CHD1 preferentially binds to relatively long A.T tracts in double-stranded DNA via minor-groove interactions. Several CHD1-binding sites were found in a well-characterized nuclear-matrix attachment region, which is located adjacent to the intronic enhancer of the kappa immunoglobulin gene. The DNA-binding activity of CHD1 was localized to a 229-amino-acid segment in the C-terminal portion of the protein, which contains sequence motifs that have previously been implicated in the minor-groove binding of other proteins. We also demonstrate that CHD1 is a constituent of bulk chromatin and that it can be extracted from nuclei with 0.6 M NaCl or with 2 mM EDTA after mild digestion with micrococcal nuclease. In contrast to another chromo-domain protein, HP1, CHD1 is not preferentially located in condensed centromeric heterochromatin, even though centromeric DNA is highly enriched in (A+T)-rich tracts. Most interestingly, CHD1 is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis. These observations lend credence to the idea that CHD1, like other proteins with chromo or helicase/ATPase domains, plays an important role in the determination of chromatin architecture.

scholarly journals The chromo domain protein Chd1p from budding yeast is an ATP-dependent chromatin-modifying factor

2000 ◽  
Vol 19 (10) ◽  
pp. 2323-2331 ◽  
Author(s):  
Hien G Tran ◽  
David J Steger ◽  
Vishwanath R Iyer ◽  
Alexander D Johnson
Keyword(s):  
Budding Yeast ◽  
Chromo Domain ◽  
Domain Protein

Characterization of a Novel Chromo Domain Gene in Xp22.3 with Homology to Drosophila msl-3

Genomics ◽  
1999 ◽  
Vol 59 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Siddharth K. Prakash ◽  
Ignatia B. Van den Veyver ◽  
Brunella Franco ◽  
Manuela Volta ◽  
Andrea Ballabio ◽  
...  
Keyword(s):  
Chromo Domain
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