scholarly journals After placebo: In medical research and clinical practice R.Nunn, ArjanaMedia 2015

2018 ◽  
Vol 24 (5) ◽  
pp. 1265-1267
Author(s):  
Cosima Locher ◽  
Jens Gaab ◽  
Michael Loughlin ◽  
Charlotte Blease
Keyword(s):  
Clinical Practice ◽  
Medical Research

Meso-Level Racism in Medicine

Contexts ◽  
2021 ◽  
Vol 20 (3) ◽  
pp. 57-59
Author(s):  
Ashley C. Rondini
Keyword(s):  
Clinical Practice ◽  
Medical Research ◽  
Medical Care ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Structural Racism ◽  
Meso Level ◽  
Medical Tests ◽  
The U.S

This article highlights that the standardization of medical care in the U.S. relies on clinical practice guidelines (CPGs), which indicate institutionalized norms about when and under what circumstances it is appropriate to administer specific medical tests and courses of treatment. However, when CPGs in medicine derive from medical research that was informed by since-debunked ideas about race, they may also facilitate structural racism.

scholarly journals Statistical methods for the analyses in clinical practice. Part 1. Univariate statistical analysis

2009 ◽  
Vol 55 (5) ◽  
pp. 48-55 ◽  
Author(s):  
P O Rumyantsev ◽  
U V Saenko ◽  
U V Rumyantseva
Keyword(s):  
Clinical Practice ◽  
Statistical Analysis ◽  
Clinical Study ◽  
Medical Research ◽  
Statistical Methods ◽  
Multivariate Statistics ◽  
Statistical Treatment ◽  
Descriptive Statistics ◽  
Integral Component ◽  
Mathematical Computation

Statistical analysis is an integral component of any clinical study. The objective of the present work was to assist clinicians in understanding various methods of statistical treatment of medical findings without going into details of mathematical computation. The most strongly sought for and popular analytical procedures are considered in application to clinical and experimental medical research. Part 1 of this communication is focused on descriptive statistics and methods of univariate statistical analysis. Part II will be concerned with the analysis of survivorship and multivariate statistics.

Ireland and Medical Research with Minors: Some Medico-Legal Aspects

2008 ◽  
Vol 15 (2) ◽  
pp. 169-181 ◽  
Author(s):  
Asim Sheikh
Keyword(s):  
Clinical Trials ◽  
Clinical Practice ◽  
Longitudinal Study ◽  
Medical Research ◽  
Blood Sample ◽  
Good Clinical Practice ◽  
Legal Aspects ◽  
Legal Issues ◽  
Sample Collection ◽  
Therapeutic Research

AbstractThe practice of medical research with minors in Ireland consist of practices pertaining to therapeutic and non-therapeutic medical research. Clinical trials (a category of therapeutic research), is governed by legislation. However, any other therapeutic research (non-clinical trials research) and non-therapeutic research, e.g. observational medical research such as a longitudinal study of children or non-therapeutic research such as blood sample collection for analysis of cause of disease, are unregulated by legislation. This, article will outline and describe some of the medico-legal issues involved in both types of research and will comment on matters such as what national law exists, how the directive on good clinical practice has been implemented, what guidelines, if any, exist.

scholarly journals Bulletin of Medical and Clinical Research

2021 ◽  
Author(s):  
Idiberto José Zotarelli Filho ◽  
Keyword(s):  
Clinical Practice ◽  
Medical Students ◽  
Clinical Research ◽  
Medical Research ◽  
Deep Understanding ◽  
Book Series

The Bulletin of Medical and Clinical Research (BMCR) is one of the new advanced Book series which focused on the new issues and developments in all aspects of general & scientific medical research and clinical practice. This volume is a welcome contribution to the all areas of Medical and Clinical Research. It is concise and accessible, yet covers the field comprehensively. Also, it demonstrates the deep understanding of the diverse theories, and presents the various viewpoints and approaches in an easily readable fashion. This book is of assistance to the medical students as well as the experienced practitioner.

scholarly journals Assessment of Awareness and Experience of Using off-label Drugs by Doctors of Clinical Specialties

Kardiologiia ◽  
2021 ◽  
Vol 61 (5) ◽  
pp. 41-50
Author(s):  
O. M. Drapkina ◽  
R. N. Shepel ◽  
S. Yu. Martsevich ◽  
N. P. Kutishenko ◽  
S. A. Berns ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Medical Research ◽  
Scientific Evidence ◽  
Research Centers ◽  
Off Label ◽  
Additional Information ◽  
National Medical ◽  
Coronavirus Infection ◽  
The Russian Federation ◽  
To Receive

Aim      To evaluate the frequency of off-label prescription of medicines in practice of clinical specialists and the awareness of respondents of the procedure of justified off-label prescription.Material and methods  The sample included 542 clinical specialists who worked in definite medical organizations in 26 entities of the Russian Federation. The respondents were proposed to fill in remotely an anonymous questionnaire to evaluate the experience of prescribing medicines off-label to adult patients.Results Prescribing medicines not in consistence with the officially approved instruction for medical use (off-label or “outside instruction”) is a relevant issue of global medical care since convincing scientific evidence for safety of such use is scarce. Analysis of information about off-label prescription is one of current tasks of national medical research centers according to the Federal Project “Development of a network of national medical research centers and implementation of innovative medical technologies”. According to the responses about the frequency of off-label prescriptions 67.5 % of respondents reported of no experience of off-label prescription, 27.7 % said “rarely” or “sometimes”, and 4.8 % said “frequently” and “very frequently”. Specialties of physicians who have more often used medicines off-label (50% and more) included obstetrics and gynecology, pediatrics, rheumatology, hematology, and pulmonology. Cardiologists, neurologists and clinical pharmacologists use medicines off-label relatively rarely (19.6%, 28.6 %, and 22.2 %, respectively). 40 % of medicines used off-label were those designed for the treatment of coronavirus infection SARS-CoV-2. The medicines most frequently used off-label included metformin, rituximab, and thioctic acid. 65 % of respondents assessed their knowledge of off-label prescription as insufficient. In addition, 75 % of respondents consider it useful to receive additional information about risks and benefits of off-label prescription in clinical practice.Conclusion      The survey revealed the need of physicians for information about risks of the off-label use of medicines in clinical practice. 

An approach to standardize, quantify and record progress of routine upper limb therapy for stroke subjects: The Action Medical Research Upper Limb Therapy protocol

Hand Therapy ◽  
2009 ◽  
Vol 14 (3) ◽  
pp. 60-68 ◽  
Author(s):  
Sheeba B Rosewilliam ◽  
Catherine BüCher ◽  
Christine Roffe ◽  
Anand D Pandyan
Keyword(s):  
Clinical Practice ◽  
Medical Research ◽  
Upper Limb ◽  
Physical Therapists ◽  
Controlled Trial ◽  
Group Discussion ◽  
Occupational Therapists ◽  
Randomized Controlled ◽  
Stage Process ◽  
Therapy Protocol

Introduction. Explicitly describing therapy for research purposes, in terms of content and quantity, improves the validity of research and facilitates evidence-based clinical practice. However, such descriptions are not common in therapy research. The aim was to develop an upper limb therapy protocol which reflected local clinical practice in the stroke unit, and a recording form to document the content, quantity and progression of therapy. Methods. This was a multi-method study. A list of interventions commonly used for the rehabilitation of the stroke upper limb was compiled following a systematic literature search. This was then refined into the Action Medical Research Upper Limb Therapy (AMRULT) protocol in a two-stage process involving a survey and a group discussion. Six physical therapists and three occupational therapists supported its development. The AMRULT protocol was then piloted in a two-arm randomized controlled trial with 90 stroke patients for therapy and recording purposes. Results. The protocol classified therapies based on therapy input as passive, active assisted, active/strengthening and functional. Using this form it was possible to not only summarize the content of therapy but also objectively document progression (e.g. 14% of the participants progressed to functional exercises between the 5th and 8th weeks after stroke onset). Discussion. The AMRULT protocol and associated recording form were useful in both standardizing the delivery and quantification (content and progression) of therapy. While the AMRULT protocol was devised for a specific purpose, the method used can be adapted to develop protocols to support other research studies.

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