scholarly journals Effect of injection of brucea javanica oil emulsion plus chemoradiotherapy for lung cancer: a review of clinical evidence

2012 ◽  
Vol 5 (4) ◽  
pp. 216-225 ◽  
Author(s):  
Yan-li Nie ◽  
Ke-xin Liu ◽  
Xuan-yue Mao ◽  
Yu-lin Li ◽  
Jing Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Evidence ◽  
Oil Emulsion ◽  
Brucea Javanica ◽  
Brucea Javanica Oil

scholarly journals Efficacy of Aidi Injection and Brucea javanica Oil Emulsion Injection in Rectal Cancer during CapeOX Adjuvant Chemotherapy

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Wenjun Meng ◽  
Xiaoge Zeng ◽  
Yuchen Gao ◽  
Qi Chen ◽  
Lian Bai
Keyword(s):  
Rectal Cancer ◽  
Adjuvant Chemotherapy ◽  
Control Group ◽  
Oil Emulsion ◽  
Brucea Javanica ◽  
Significant Difference ◽  
Hand Foot Syndrome ◽  
Aidi Injection ◽  
One Year ◽  
Brucea Javanica Oil

Background. Adjuvant chemotherapy with CapeOX regimen is widely used in resected rectal cancer, which brings benefits to patients. But drug-related toxicities are severe during this process; thus, survival outcomes may potentially be affected. This study explored the efficacy of two Chinese herbal injections, Aidi injection (ADI) and Brucea javanica oil emulsion injection (BJOEI), as adjuvant drugs in CapeOX adjuvant chemotherapy on rectal cancer patients. Methods. A total of 240 cases were enrolled in this retrospective study. 80 cases received CapeOX with ADI (the ADI group), 80 cases received CapeOX with BJOEI (the BJOEI group), and the rest 80 cases received CapeOX alone (the control group). After four cycles’ chemotherapy, adverse reactions (ADRs) and quality of life (QOL) were analyzed. Then, patients received follow-up for at least one year, and the endpoint was disease-free survival (DFS). Results. All patients completed at least four cycles’ adjuvant chemotherapy. The incidence of leukopenia and thrombocytopenia was significantly lower in the ADI group; the incidence of nausea was significantly lower in the BJOEI group; the incidence of hand-foot syndrome was significantly lower in both the ADI group and BJOEI group. Significant difference was found in the control group regarding the Karnofsky Performance Status (KPS) scores prior and posttreatment. No difference was found among three groups regarding one-year DFS. Conclusion. As adjuvant drugs for rectal cancer during CapeOX chemotherapy, ADI shows advantages in decreasing leukopenia and thrombocytopenia, while BJOEI results better in remitting nausea. Both two CHIs had positive impacts on decreasing hand-foot syndrome and the maintenance of patients’ QOL. It is worthy of further study and promotion for CHIs.

scholarly journals Efficacy and safety of Brucea javanica oil emulsion for liver cancer

Medicine ◽  
2020 ◽  
Vol 99 (47) ◽  
pp. e23197
Author(s):  
Didi Luo ◽  
Daorui Hou ◽  
Tiancheng Wen ◽  
Meiling Feng ◽  
Haiming Zhang
Keyword(s):  
Liver Cancer ◽  
Efficacy And Safety ◽  
Oil Emulsion ◽  
Brucea Javanica ◽  
Brucea Javanica Oil

scholarly journals Involvement of autophagy inhibition in Brucea javanica oil emulsion-induced colon cancer cell death

2015 ◽  
Vol 9 (3) ◽  
pp. 1425-1431 ◽  
Author(s):  
ZHENG YAN ◽  
BEI ZHANG ◽  
YUANYUAN HUANG ◽  
HUIJUAN QIU ◽  
PING CHEN ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Oil Emulsion ◽  
Brucea Javanica ◽  
Cancer Cell Death ◽  
Autophagy Inhibition ◽  
Brucea Javanica Oil

scholarly journals The Efficacy of Brucea javanica Oil Emulsion Injection as Adjunctive Therapy for Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Wei Xu ◽  
Xinchan Jiang ◽  
Zhengyuan Xu ◽  
Tong Ye ◽  
Qionghua Shi
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Advanced Nsclc ◽  
Meta Analysis ◽  
Small Cell ◽  
Nausea And Vomiting ◽  
Small Cell Lung ◽  
Oil Emulsion ◽  
Brucea Javanica

Purpose. To evaluate the efficacy of Brucea javanica oil emulsion injection (BJOEI) in patients with advanced non-small-cell lung cancer (NSCLC) during chemotherapy. Method. Electronic database of EMBASE and PubMed and the conference proceeding of ASCO, CNKI, CBMdisc, VIP, and Wanfang database were searched to select RCTs comparing BJOEI plus chemotherapy with chemotherapy alone in the treatment of advanced NSCLC, until June 1, 2016. Two reviewers independently performed the analysis according to the inclusion and exclusion criteria. Review Manager 5.3 and STATA 12.0 were employed for data analysis. Result. Twenty-one studies including 2234 cases were included. The pooled result indicated that there were significant differences in ORR (RR=1.25; 95% CI: 1.14–1.36; P<0.00001), improvement of QOL (RR=1.87; 95% CI: 1.63–2.15; P<0.00001), nausea and vomiting (RR=0.67; 95% CI: 0.46–0.98; P=0.04), leukopenia (RR=0.63; 95% CI: 0.52–0.75; P<0.00001), but there was no difference in thrombocytopenia (RR=0.78; 95% CI: 0.49–1.23; P=0.29). Begg’s funnel plot and Egger’s test indicated that no publication bias was found. The sensitivity analysis suggested the stability of the pooled result. Conclusion. The addition of BJOEI can enhance efficacy, improve QOL, and decrease incidence of nausea and vomiting and leukopenia for advanced NSCLC patients. However, higher quality RCTs are needed to further confirm this finding.

scholarly journals The Promotional Effect of Hollow MnO2 with Brucea Javanica Oil Emulsion (BJOE) on Endometrial Cancer Apoptosis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Qin Hu ◽  
Shu Zhang ◽  
Jun Zhu ◽  
Lina Yin ◽  
Suping Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Proliferation ◽  
Endometrial Cancer ◽  
Cancer Cells ◽  
Vital Role ◽  
New Paradigm ◽  
Oil Emulsion ◽  
Gynecological Malignancy ◽  
Brucea Javanica ◽  
Brucea Javanica Oil

Endometrial cancer (EC) is a common gynecological malignancy worldwide whose therapy mainly depends on chemotherapy. In past years, an increasing number of studies indicate that hollow MnO2 could serve as a nanoplatform in the drug delivery system. The Brucea javanica oil emulsion (BJOE) has been illustrated to play a vital role in cancers. However, knowledge about the combined effect of H-MnO2-PEG/BJOE in endometrial cancer remains ambiguous up to now. In the present work, we prepared a drug-delivery vector H-MnO2-PEG by chemical synthesis and found that H-MnO2-PEG significantly inhibited cell proliferation in endometrial cancer cells. Moreover, the combination of H-MnO2-PEG/BJOE could repress cell proliferation more efficiently and promote cell apoptosis. Mechanistically, we found that BJOE exerted its role as a promoter of endometrial apoptosis by regulating relative protein expressions. In general, the present study demonstrates that H-MnO2-PEG functions as a critical vector in the tumor microenvironment of endometrial cancer and the significant effect of H-MnO2-PEG/BJOE on cancer cells, suggesting a new paradigm for the treatment of endometrial cancer.

Sign in / Sign up

Export Citation Format

Share Document