Apremilast in multibacillary leprosy patients with chronic and recurrent erythema nodosum leprosum: A prospective single centre pilot study

2021 ◽  
Author(s):  
Tarun Narang ◽  
Raihan Ashraf ◽  
Akanksha Kaushik ◽  
Sunil Dogra
Keyword(s):  
Pilot Study ◽  
Erythema Nodosum ◽  
Single Centre ◽  
Erythema Nodosum Leprosum ◽  
Leprosy Patients ◽  
Multibacillary Leprosy

scholarly journals A Retrospective Study: Epidemiology, Onset, and Duration of Erythema Nodosum Leprosum in Surabaya, Indonesia

2021 ◽  
Vol 33 (1) ◽  
pp. 8
Author(s):  
Cindy Fransisca ◽  
Iskandar Zulkarnain ◽  
Evy Ervianti ◽  
Damayanti Damayanti ◽  
Maylita Sari ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Retrospective Study ◽  
Erythema Nodosum ◽  
First Year ◽  
Erythema Nodosum Leprosum ◽  
Regular Control ◽  
Leprosy Patients ◽  
Multibacillary Leprosy

Background: Erythema nodosum leprosum (ENL) has a chronic and recurrent nature which could reduce patient’s quality of life in addition to the onset of ENL that occurs before, during, or after multidrug treatment, further emphasizing the importance of regular control and education.Purpose:This study aimed to evaluate the epidemiology, onset, duration, and recurrence of ENL. Methods:Data from medical records were obtained for a 3-year retrospective study of multibacillary leprosy patients at the Leprosy Division of the Dermatology and Venereology Outpatient Department, Dr. Soetomo General Hospital Surabaya, with a minimum of 2–5 years follow-up period.Result:The prevalence of  ENL continued to increase almost every year especially in 2017 (32% in 2015; 32% in 2016; and 36% in 2017). ENL most often occurs during the first year of multi-drug therapy (MDT) administration followed by after the release from treatment (RFT) with the latest onset occurring 4 years after RFT. The majority of patients experienced chronic and recurrent reactions with the longest reactions lasting up to 4.5 years (55 months). Conclusion:Knowledge about the onset, duration, and recurrences of ENL are essential, and strict supervision for routine control shall be encouraged to increase the patients’ compliance so as to increase their quality of life.

Unusual non-trophic ulcerations in leprosy: A case series of 17 patients

2021 ◽  
pp. 004947552199849
Author(s):  
Prakriti Shukla ◽  
Kiran Preet Malhotra ◽  
Parul Verma ◽  
Swastika Suvirya ◽  
Abir Saraswat ◽  
...  
Keyword(s):  
Erythema Nodosum ◽  
Case Series ◽  
Lepromatous Leprosy ◽  
Sweet Syndrome ◽  
Erythema Nodosum Leprosum ◽  
Leprosy Patients ◽  
Atypical Presentations ◽  
Neuropathic Ulcers

Non-neuropathic ulcers in leprosy patients are infrequently seen, and atypical presentations are prone to misdiagnosis. We evaluated diagnosed cases of leprosy between January 2017 and January 2020 for the presence of cutaneous ulceration, Ridley–Jopling subtype of leprosy, reactions and histologic features of these ulcerations. Treatment was given as WHO recommended multi-bacillary multi-drug therapy. We found 17/386 leprosy patients with non-neuropathic ulcers. We describe three causes – spontaneous cutaneous ulceration in lepromatous leprosy (one nodular and one diffuse), lepra reactions (five patients with type 1; nine with type 2, further categorised into ulcerated Sweet syndrome-like who also had pseudoepitheliomatous hyperplasia, pustulo-necrotic and necrotic erythema nodosum leprosum) and Lucio phenomenon (one patient). Our series draws attention towards the different faces of non-neuropathic ulcers in leprosy, including some atypical and novel presentations.

scholarly journals Effectiveness of the retreatment of patients with multibacillary leprosy and episodes of erythema nodosum leprosum and/or persistent neuritis: a single-center experience

2018 ◽  
Vol 93 (2) ◽  
pp. 181-184 ◽  
Author(s):  
Joel Carlos Lastória ◽  
Thaís Sampaio Corrêa de Almeida ◽  
Maria Stella de Mello Ayres Putinatti ◽  
Carlos Roberto Padovani
Keyword(s):  
Erythema Nodosum ◽  
Single Center ◽  
Single Center Experience ◽  
Erythema Nodosum Leprosum ◽  
Multibacillary Leprosy

scholarly journals A Case Report of Multibacillary Leprosy Presenting with Multiple Outbreaks of Erythema Nodosum Leprosum

2019 ◽  
Vol 77 (1) ◽  
pp. 67-72
Author(s):  
R. Bouceiro-Mendes ◽  
A. Ortins-Pina ◽  
T. Marques ◽  
M. Viveiros ◽  
D. Machado ◽  
...  
Keyword(s):  
Erythema Nodosum ◽  
Mycobacterium Leprae ◽  
Endemic Region ◽  
Appropriate Care ◽  
Erythema Nodosum Leprosum ◽  
Mucous Membranes ◽  
Atypical Presentations ◽  
Multibacillary Leprosy ◽  
Skin Phototype

Leprosy is a chronic granulomatous disease with a long incubation period caused by Mycobacterium leprae that mainly affects the skin, mucous membranes and the peripheral nervous system. It carries the risk of per-manent sequels with a significant impact on the patient’s quality of life. It has a considerable clinically diver-sity and possible atypical presentations. We present a case of a 31-year-old, skin phototype V woman with multibacillary leprosy characterized by multiple outbreaks of erythema nodosum leprosum, as an inaugural manifestation of the disease. The disease was acquired within a group of children and adolescents from an endemic region of Africa, evolved untreated for 3 years, and presented with unusual features and remarkable lymphatic involvement. We highlight the importance of building and maintaining collaboration between expert centers and institutional partnerships in order to provide the adequate diagnostic resources and appropriate care to the affected populations.

scholarly journals The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions

2018 ◽  
Vol 12 (12) ◽  
pp. e0007035 ◽  
Author(s):  
Edessa Negera ◽  
Melaku Tilahun ◽  
Kidist Bobosha ◽  
Saba M. Lambert ◽  
Stephen L. Walker ◽  
...  
Keyword(s):  
Erythema Nodosum ◽  
Lipid Profiles ◽  
Prednisolone Treatment ◽  
Erythema Nodosum Leprosum ◽  
Leprosy Patients

Erythema nodosum leprosum as the presenting feature in multibacillary leprosy

2009 ◽  
Vol 15 (6) ◽  
Author(s):  
Smitha Prabhu ◽  
S D Shenoi ◽  
B Sathish Pai ◽  
H Sripathi
Keyword(s):  
Erythema Nodosum ◽  
Erythema Nodosum Leprosum ◽  
Multibacillary Leprosy
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