scholarly journals Cutaneous reactions to inactivated SARS‐CoV‐2 vaccine and ChAdOx1‐S (recombinant) vaccine against SARS‐CoV‐2: A case series from the Philippines

2021 ◽  
Author(s):  
J.N. Yu ◽  
C.B. Angeles ◽  
H.G. Lim ◽  
C. Chavez ◽  
C. Roxas‐Rosete
Keyword(s):  
Case Series ◽  
The Philippines ◽  
Recombinant Vaccine ◽  
Cutaneous Reactions

Neuromyelitis optica spectrum disorder in a tertiary hospital in the Philippines: a case series

2019 ◽  
Vol 31 ◽  
pp. 124-130 ◽  
Author(s):  
Adrian I. Espiritu ◽  
Bryan Vincent Q. Mesina ◽  
Athena Angellie DL. Puerto ◽  
Nikolai Gil D. Reyes ◽  
Ludwig F. Damian ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Case Series ◽  
Tertiary Hospital ◽  
The Philippines ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder

Is SARS-CoV-2 transmitted by asymptomatic and pre-symptomatic infected individuals?

2021 ◽  
Vol 54 ◽  
Author(s):  
Abigail F. Melicor ◽  
Katrina Loren R. Rey ◽  
Leonila F. Dans
Keyword(s):  
Case Reports ◽  
Case Series ◽  
The Philippines ◽  
World Health ◽  
Current Evidence ◽  
Wide Confidence Interval ◽  
Cross Sectional ◽  
Viral Shedding ◽  
Asymptomatic Patients ◽  
Health Organization

KEY FINDINGSAsymptomatic and pre-symptomatic transmission of SARS-CoV-2 may occur.• Manifestations of COVID-19 are highly varied and may include asymptomatic cases, who do not manifest with anysigns and symptoms despite testing positive for COVID-19 by viral nucleic acid tests. Pre-symptomatic cases areinfected individuals who are still in their incubation period, hence do not exhibit any symptoms yet but eventuallydevelop symptoms.• As of June 2020, only 586 (2.8%) of the 20,990 active cases in the Philippines were classified as asymptomatic,but it is unclear whether cases are pre-symptomatic or carriers (true asymptomatic).• Based on 36 observational studies (case reports, case series, cross-sectional and cohort studies) and 9 statisticalmodeling analysis, asymptomatic and pre-symptomatic transmission of SARS-CoV-2 may occur. However, 3studies reported no transmission from pre-symptomatic and asymptomatic cases.• Studies on viral load comparing symptomatic cases with pre-symptomatic and asymptomatic cases reportedcontradicting results. The duration of viral shedding was significantly longer for symptomatic patients comparedto asymptomatic patients but similar for asymptomatic and pre-symptomatic patients.• Therewas no difference in the transmission rates of symptomatic and asymptomatic cases. However,the estimatedinfectivity and probability of transmission was higherfor symptomatic cases compared to asymptomatic cases, butresults were imprecise due to a wide confidence interval.• The World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) recognize thepossibility of pre-symptomatic and asymptomatic transmission. According to WHO, current evidence suggestsasymptomatic cases are less likely to transmit the virus than symptomatic cases.

scholarly journals Dyke-Davidoff-Masson Syndrome in the Philippines: A Case Series

2015 ◽  
Vol 49 (1) ◽  
Author(s):  
Christine C. Sia ◽  
Mina N. Astejada
Keyword(s):  
Case Series ◽  
The Philippines

...

scholarly journals Maxillary Sinus Squamous Cell Carcinoma in a Tertiary Hospital in the Philippines

2019 ◽  
Vol 34 (1) ◽  
pp. 34-37
Author(s):  
Anna Kristina M. Hernandez ◽  
Arsenio Claro A. Cabungcal
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Maxillary Sinus ◽  
General Hospital ◽  
Squamous Cell ◽  
Case Series ◽  
The Philippines ◽  
Chief Complaint ◽  
Initial Symptoms ◽  
Sinus Cancer

Objective: To establish preliminary demographic and clinicopathologic data on Maxillary Sinus Squamous Cell Carcinoma (SCC) in the Philippine General Hospital Methods:                  Design:           Retrospective Case Series           Setting:           Tertiary National University Hospital           Participants: Socio-demographic and clinical data from records of 22 patients admitted at the Department of Otorhinolaryngology of the Philippine General Hospital from 2013-2016 and histopathologically confirmed to have Maxillary Sinus SCC, were collected and described using means and proportions. Results: There were 15 males and 7 females with a mean age of 50-years-old (range 24 to 77-years-old). Maxillary mass/swelling was the most common chief complaint.  The mean gap between initial symptoms and consult was 6.77 months.  Initial biopsies were obtained from the maxillary sinus in 16 patients, with 1 patient noted to have undergone malignant transformation from a prior intranasal squamous papilloma.  Staging was advanced (Stage IVA in 16, IVB in 4, and III in 2), with no patients with Stage I or II disease.  Sixteen (16) patients underwent surgery and radiotherapy, while 6 patients received radiotherapy (RT) with or without chemotherapy.  Regional and distant metastases were uncommon. Conclusion: In this series, maxillary sinus SCC occurs more in males, with a maxillary mass as the most common chief complaint.  Delay in treatment is common, with a mean gap of 6 months between initial symptoms and consult.  Neck node metastasis is uncommon, and most patients undergo surgery with radiotherapy as treatment.   Keywords: maxillary sinus cancer; paranasal sinus cancer; squamous cell carcinoma  

scholarly journals Contents Vol. 34 no. 1 January – June 2019

2020 ◽  
Vol 34 (1) ◽  
pp. 3
Author(s):  
Philipp J Otolaryngol Head and Neck Surg
Keyword(s):  
Arteriovenous Malformation ◽  
Total Thyroidectomy ◽  
Meta Analysis ◽  
Case Series ◽  
The Philippines ◽  
Provincial Government ◽  
University Hospital ◽  
Postpartum Woman ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Papillary Thyroid

EDITORIAL 4 Authorship Controversies: Gift, Guest and Ghost Authorship Lapeña JF META-ANALYSIS 6 Morbidity Outcomes of Prophylactic Central Neck Dissection with Total Thyroidectomy versus Total Thyroidectomy Alone in Patients with Node-Negative Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies Sison CZI, Fernando AF, Gutierrez TMDG ORIGINAL ARTICLES 14 Levothyroxine versus Levothyroxine with Iodine in Reduction of Thyroid Nodule Volume: A Double-Blind Randomized Controlled Trial Segocio DJD, Cachuela JE 20 The Use of Bony Septum as an Extended Spreader Graft in Primary and Secondary Rhinoplasty Que-Ansorge C, Yap EC 26 Clinical Profile of Filipino Patients with Epistaxis in a University Hospital Gutierrez TMD, Lerma FJV 30 Advanced Laryngotracheal Stenosis Patients in a Tertiary Provincial Government Hospital: A Prospective Case Series Villanueva JVM, Soriano RG 34 Maxillary Sinus Squamous Cell Carcinoma in a Tertiary Hospital in the Philippines Hernandez AKM, Cabungcal ACA 38 Usability of a Smartphone Application for Preoperative Facial Analysis for Rhinoplasty among ENT Surgeons Padua PFC, Dela Cruz APIC, Pascual RC, Cambe SMM CASE REPORTS 44 Aggressive Tuberculous Otitis Media in a Young Child Canta LAB, Dizon APJE, Abes FLLB 48 Non-Traumatic Cerebrospinal Fluid Leak from a Sphenoid Sinus Midline Roof Defect Previously Managed as Allergic Rhinitis Formalejo JPD, Amable JPM 52 Arteriovenous Malformation of the Mandible in a Young Postpartum Woman Mercado GAG, Delovino KAE, Carpela AB 56 Intraosseus Arteriovenous Malformation of the Mandible: Extracorporeal Curettage and Immediate Replantation Tongol EA, Pontejos AQY, Fullante PB, Cabungcal ACA, Ong KMC SURGICAL INNOVATION AND INSTRUMENTATION 60 Autologous Tracheal Cartilage Composite Graft for a Subglottic Defect after Laryngotracheal Resection for Invasive Papillary Thyroid Carcinoma Crisostomo MV, Ureta CV FEATURED GRAND ROUNDS 64 Solitary Fibrous Tumor of the Larynx and Anterior Neck Pabayos GS, Chiong AM UNDER THE MICROSCOPE 68 Intracapsular Carcinoma ex Pleomorphic Adenoma Carnate JM, Masalunga MC  

scholarly journals Melioidosis in the Philippines

2018 ◽  
Vol 3 (3) ◽  
pp. 99
Author(s):  
Peter San Martin ◽  
Joseph Chua ◽  
Ralph Bautista ◽  
Jennifer Nailes ◽  
Mario Panaligan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Soft Tissue ◽  
Mortality Rate ◽  
Surveillance System ◽  
Case Series ◽  
The Philippines ◽  
Soft Tissue Infections ◽  
Intensive Phase ◽  
Co Morbidity ◽  
Tertiary Hospitals

The first documented case of melioidosis in the Philippines occurred in 1948. Since then, there have been sporadic reports in the literature about travelers diagnosed with melioidosis after returning from the Philippines. Indigenous cases, however, have been documented rarely, and under-reporting is highly likely. This review collated all Philippine cases of melioidosis published internationally and locally, as well as unpublished case series and reports from different tertiary hospitals in the Philippines. In total, 25 papers and 41 cases were identified. Among these, 23 were indigenous cases (of which 20 have not been previously reported in the literature). The most common co-morbidity present was diabetes mellitus, and the most common presentations were pulmonary and soft tissue infections. Most of the cases received ceftazidime during the intensive phase, while trimethoprim-sulfamethoxazole was given during the eradication phase. The known mortality rate was 14.6%, while 4.9% of all cases were reported to have had recurrence. The true burden of melioidosis in the country is not well defined. A lack of awareness among clinicians, a dearth of adequate laboratories, and the absence of a surveillance system for the disease are major challenges in determining the magnitude of the problem.

Effect of concomitant HIV infection on adverse drug reactions by first line antitubercular drugs - a case series analysis

2020 ◽  
Vol 3 (3) ◽  
pp. 222-225
Author(s):  
Alka Bansal ◽  
Lokendra Sharma
Keyword(s):  
Hiv Infection ◽  
Adverse Drug Reactions ◽  
Case Series ◽  
Individual Case ◽  
Drug Reactions ◽  
First Line ◽  
Drug Induced ◽  
Antitubercular Drugs ◽  
Cutaneous Reactions ◽  
Recovery Status

The pattern and severity of adverse drug reactions (ADRs) due to first-line anti-tubercular drugs in solely tubercular and TB-HIV co-infected patients could be different due to drug-disease and drug-drug interactions in TB-HIV co-infected patients. Nevertheless, the studies regarding this aspect are very meager. Hence a retrospective appraisal of individual case safety reports (ICSR) due to first-line antitubercular drugs spontaneously submitted to the ADR monitoring center was done for solely tubercular and TB-HIV coinfected patients. Out of eight ICSRs, four had concomitant HIV infection, and two of them were on antiretroviral (ARV) drugs. Co-infected patients showed rare and severe ADRs like optic neuritis, acute renal failure, and drug-induced liver injury (DILI). In contrast, four non-HIV co-infected tubercular patients suffered from comparatively less severe cutaneous reactions and vertigo. A high negative (-0.774) correlation coefficient between HIV co-infection and recovery status found that HIV co-infected patients had low chances of fully recovering. In conclusion, HIV co-infection and ARV drugs can affect the pattern, severity, and recovery status of adverse drug reactions due to first-line antitubercular drugs.

Cefaclor-Associated Serum Sickness-Like Disease: Eight Cases and Review of the Literature

1992 ◽  
Vol 26 (7-8) ◽  
pp. 910-914 ◽  
Author(s):  
Thierry Vial ◽  
Jacqueline Pont ◽  
Emmanuel Pham ◽  
Muriel Rabilloud ◽  
Jacques Descotes
Keyword(s):  
Clinical Features ◽  
Case Reports ◽  
Case Series ◽  
Epidemiologic Studies ◽  
Serum Sickness ◽  
Under Five ◽  
Causative Relationship ◽  
Clinical Presentations ◽  
Pharmacovigilance Center ◽  
Cutaneous Reactions

OBJECTIVE: To describe the clinical features of serum sickness-like diseases (SSLD) in cefaclor-treated patients. DESIGN: Analysis of a case series spontaneously reported to Lyons Pharmacovigilance Center. SETTING: General and hospital practitioners and the French Network of Regional Pharmacovigilance Centers (FNRPC). PATIENTS: All reported cases with a possible causative relationship between cefaclor treatment and SSLD. MAIN RESULTS: Eight cases of SSLD following cefaclor treatment are described. The clinical features included cutaneous reactions, arthralgias, and moderate hyperthermia. In 50 percent of the patients, hospitalization was required because of incapacitating symptoms. The outcome was benign in all cases following discontinuation of the offending drug. All eight cases were reported in children under five years of age. Among 137 cefaclor-associated drug reactions collected by FNRPC, 27 cases of SSLD have been reported; 23 of these patients were younger than five years of age. A literature survey confirmed the higher reporting of SSLD in children with cefaclor compared with other antibiotics and suggested an incidence of 0.024–0.2 percent of SSLD per drug course of cefaclor. CONCLUSIONS: The case reports and epidemiologic studies confirmed the presumed role of age (patients under five years of age) in cefaclor-induced SSLD and the benign outcome despite severe clinical presentations in some reports.

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