scholarly journals Undertreatment in adult patients with moderate‐to‐severe atopic dermatitis and other chronic inflammatory skin diseases

2020 ◽  
Vol 34 (10) ◽  
pp. 2168-2169
Author(s):  
P. Gisondi ◽  
G. Girolomoni
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Adult Patients ◽  
Severe Atopic Dermatitis ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

scholarly journals Relationship between Skin Microbiota and Skin Biophysical Parameters in Inflammatory Skin Disease: A Systematic Review

2021 ◽  
Vol 7 (1) ◽  
pp. 1-6
Author(s):  
Paola Perugini ◽  
Keyword(s):  
Systematic Review ◽  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Bacterial Flora ◽  
Skin Microbiota ◽  
Biophysical Parameters ◽  
Microbial Composition ◽  
Inflammatory Skin Diseases ◽  
Starting Point ◽  
Inflammatory Skin

Many recent studies highlight the importance of skin microbiota for skin health. Alterations in the balance of bacterial flora cause the development of inflammatory skin diseases such as acne, atopic dermatitis, or psoriasis. This systematic review aims to investigate the relationship, in these skin diseases, between skin microbiota and skin biophysical parameters, such as pH, Transepidermal Water Loss (TEWL), Hydration (HI) and sebum levels. Google Scholar, Medline via Pubmed, and Web of Science were considered as scientific database to search studies about this topic. Research about acne and psoriasis did not produce any results. For this reason, in this review, only articles concerning atopic dermatitis were discussed. Therefore, a possible correlation between skin barrier functionality and microbial composition was also investigated. So, this could be a starting point for the diagnosis of atopic dermatitis or, more generally, for all inflammatory skin diseases.

scholarly journals Effect of Neferine on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice

2021 ◽  
Vol 22 (15) ◽  
pp. 8237
Author(s):  
Chung-Chi Yang ◽  
Yen-Ling Hung ◽  
Wen-Chin Ko ◽  
Yi-Ju Tsai ◽  
Jia-Feng Chang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Inflammatory Diseases ◽  
Biological Activities ◽  
Transepidermal Water Loss ◽  
Hacat Cells ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

Atopic dermatitis (AD) is a chronic and persistent inflammatory skin disease characterized by eczematous lesions and itching, and it has become a serious health problem. However, the common clinical treatments provide limited relief and are accompanied by adverse effects. Therefore, there is a need to develop novel and effective therapies to treat AD. Neferine is a small molecule compound isolated from the green embryo of the mature seeds of lotus (Nelumbo nucifera). It has a bisbenzylisoquinoline alkaloid structure. Relevant studies have shown that neferine has many pharmacological and biological activities, including anti-inflammatory, anti-thrombotic, and anti-diabetic activities. However, there are very few studies on neferine in the skin, especially the related effects on inflammatory skin diseases. In this study, we proved that it has the potential to be used in the treatment of atopic dermatitis. Through in vitro studies, we found that neferine inhibited the expression of cytokines and chemokines in TNF-α/IFN-γ-stimulated human keratinocyte (HaCaT) cells, and it reduced the phosphorylation of MAPK and the NF-κB signaling pathway. Through in vivo experiments, we used 2,4-dinitrochlorobenzene (DNCB) to induce atopic dermatitis-like skin inflammation in a mouse model. Our results show that neferine significantly decreased the skin barrier damage, scratching responses, and epidermal hyperplasia induced by DNCB. It significantly decreased transepidermal water loss (TEWL), erythema, blood flow, and ear thickness and increased surface skin hydration. Moreover, it also inhibited the expression of cytokines and the activation of signaling pathways. These results indicate that neferine has good potential as an alternative medicine for the treatment of atopic dermatitis or other skin-related inflammatory diseases.

scholarly journals Characterization of Circular RNA Transcriptomes in Psoriasis and Atopic Dermatitis Reveals Disease-specific Expression Profiles

2020 ◽  
Author(s):  
Liviu Ionut Moldovan ◽  
Lam Alex Tsoi ◽  
Stephen Weidinger ◽  
Johann Gudjonsson ◽  
Jørgen Kjems ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Expression Profiles ◽  
Circular Rna ◽  
Detection Algorithm ◽  
Healthy Skin ◽  
Inflammatory Skin Diseases ◽  
Specific Expression ◽  
Lesional Skin ◽  
Inflammatory Skin

AbstractBackgroundAtopic dermatitis (AD) and psoriasis, two chronic inflammatory skin diseases, affect a large number of individuals worldwide, and are associated with various comorbidities. Circular RNA (circRNA) constitute a major class of non-coding RNAs that have been implicated in many human diseases, although their potential involvement in inflammatory skin diseases remains elusive.ObjectivesTo compare and contrast the circRNA expression landscapes in paired lesional and non-lesional skin from psoriasis and AD patients relative to skin from unaffected individuals. Moreover, to correlate circRNA expression to disease severity.MethodsWe analyzed high-depth RNA-seq data from paired lesional and non-lesional skin samples from 27 AD patients, 28 psoriasis patients, and 38 healthy controls. CircRNAs and their cognate linear transcripts were quantified using the circRNA detection algorithm, CIRI2.ResultsWe identified 39,286 unique circRNAs in total and found that psoriasis and AD lesional skin could be distinguished from non-lesional and healthy skin based on circRNA expression landscapes. In general, circRNAs were less abundant in lesional relative to non-lesional and healthy skin. Differential expression analyses revealed many significantly downregulated circRNAs, mainly in psoriasis lesional skin, and a strong correlation between psoriasis and AD-related circRNA expression changes was observed. A subset of circRNAs, including ciRS-7, was specifically dysregulated in psoriasis and show promise as biomarkers for discriminating AD from psoriasis.ConclusionPsoriasis and circRNA transcriptomes share expression features, including a global downregulation, but only psoriasis is characterized by several circRNAs being dysregulated independently of their cognate linear transcripts.

scholarly journals Oxidative Stress and Alterations of Paraoxonases in Atopic Dermatitis

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 697
Author(s):  
Oriana Simonetti ◽  
Tiziana Bacchetti ◽  
Gianna Ferretti ◽  
Elisa Molinelli ◽  
Giulio Rizzetto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Lipid Hydroperoxides ◽  
Polymorphonuclear Cells ◽  
Inflammatory Skin Diseases ◽  
Total Antioxidant ◽  
Inflammatory Skin ◽  
Total Antioxidant Potential ◽  
The Relationship

Background: previous studies reported the involvement of reactive oxygen species (ROS) and lipid peroxidation in the pathogenesis of inflammatory skin diseases. The aim of our study was to investigate the relationship between oxidative stress and inflammation in children affected by atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. Methods: levels of lipid hydroperoxides, total antioxidant capacity, and activities of the enzymes myeloperoxidase (MPO), PON1, and PON2/3 were investigated in 56 atopic pediatric patients, and compared with 48 sex-/age-matched healthy controls. Results: significantly higher levels of lipid hydroperoxides and lower values of total antioxidant potential were observed in the serum of AD children compared to that of the controls. Significant lower PON1 activities, and a significant increase in levels of MPO were observed in serum of patients, with a higher serum MPO level/PON1 paraoxonase activity ratio in patients compared to that in the controls. Significantly lower lactonase activity of PON enzymes was observed in polymorphonuclear cells isolated from AD patients. Statistically negative correlation was established between the activity of intracellular PON2/3 activity and ROS levels. Conclusions: our data confirmed that AD is associated with higher oxidative damage and a decrease in antioxidant defense. Moreover, alterations of extracellular and intracellular PON activity can promote lipoprotein dysfunction in AD patients.

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