Microenvironment in cutaneous melanomas: a gene expression profile study may explain the role of histological regression

Author(s):  
S. Osella‐Abate ◽  
C. Vignale ◽  
L. Annaratone ◽  
A. Nocifora ◽  
L. Bertero ◽  
...  
2013 ◽  
Vol 102 (8) ◽  
pp. 2833-2841 ◽  
Author(s):  
Xiaoying Lü ◽  
Jiandan Wang ◽  
Bin Li ◽  
Zhiwei Zhang ◽  
Lifeng Zhao

2006 ◽  
Vol 6 (4) ◽  
pp. 157-165 ◽  
Author(s):  
S. Gambardella* ◽  
M. Biancolella* ◽  
M. R. D'Apice ◽  
F. Amati ◽  
F. Sangiuolo ◽  
...  

2002 ◽  
Vol 48 (2) ◽  
pp. 216-225
Author(s):  
NOBUHIKO TACHIBANA ◽  
TAKURO FUJIMAKI ◽  
SHINJI NAKAMURA ◽  
TOSHINARI FUNAKI ◽  
AKIRA MURAKAMI

Author(s):  
Patricia Sanz-Ramos ◽  
Javier Dotor ◽  
Iñigo Izal-Azcárate

AbstractWe aim to demonstrate the role of Alk receptors in the response of hydrogel expansion. Chondrocytes from rat knees were cultured onto plastic and hydrogel surfaces. Alk-1 and Alk-5 were overexpressed or silenced and the effects on cells during expansion were tested and confirmed using peptide inhibitors for TGFβ. Overexpression of Alk-5 and silencing of Alk-1 led to a loss of the chondrocyte phenotype, proving that they are key regulators of chondrocyte mechanosensing. An analysis of the gene expression profile during the expansion of these modified cartilage cells in plastic showed a better maintenance of the chondrocyte phenotype, at least during the first passages. These passages were also assayed in a mouse model of intramuscular chondrogenesis. Our findings indicate that these two receptors are important mediators in the response of chondrocytes to changes in the mechanical environment, making them suitable targets for modulating chondrogenesis. Inhibition of TGFβ could also be effective in improving chondrocyte activity in aged or expanded cells that overexpress Alk-1.


2011 ◽  
Vol 156 (1-2) ◽  
pp. 25-34 ◽  
Author(s):  
Atthapan Morchang ◽  
Umpa Yasamut ◽  
Janjuree Netsawang ◽  
Sansanee Noisakran ◽  
Wiyada Wongwiwat ◽  
...  

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 983-984
Author(s):  
S. Sánchez Sosa ◽  
C. Bilbao Sieyro ◽  
Y. Florido Ortega ◽  
E. González Pérez ◽  
M. D. L. N. Saez Perdomo ◽  
...  

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e91010 ◽  
Author(s):  
Cristina Nodale ◽  
Simona Ceccarelli ◽  
Mariateresa Giuliano ◽  
Marcella Cammarota ◽  
Sirio D’Amici ◽  
...  

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