scholarly journals Cutaneous small vessel vasculitis secondary to COVID‐19 infection: a case report

2020 ◽  
Vol 34 (10) ◽  
Author(s):  
A. Mayor‐Ibarguren ◽  
M. Feito‐Rodriguez ◽  
L. Quintana Castanedo ◽  
E. Ruiz‐Bravo ◽  
D. Montero Vega ◽  
...  
Keyword(s):  
Case Report ◽  
Small Vessel ◽  
Small Vessel Vasculitis

scholarly journals MULTIPLE MYELOMA PRESENTING AS SMALL VESSEL VASCULITIS IN A PATIENT WITH NO CRYOGLOBULINEMIA: CASE REPORT

2021 ◽  
Author(s):  
Túlio Silva Freire ◽  
Villane Matheus Fernandes Silva ◽  
Raquel Anne Bacurau Monteiro ◽  
Hugo Deleon de Lima ◽  
Guilherme Augusto Silva ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Small Vessel ◽  
Small Vessel Vasculitis

scholarly journals Sudden Cardiac Death Caused by Cardiac Small Vessel Vasculitis after COVID-19 Vaccination (BNT162b2 nCov-19): A Case Report

2021 ◽  
Vol 45 (4) ◽  
pp. 133-138
Author(s):  
Sohyung Park ◽  
Min Kyoung Kim ◽  
Kanghyun Baek
Keyword(s):  
Diabetes Mellitus ◽  
Case Report ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Vascular Dysfunction ◽  
Postmortem Examination ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Chronic Hypertension ◽  
Inflammatory Syndrome

This study presents a case of sudden cardiac death due to cardiac small vessel vasculitis after coronavirus disease 2019 (COVID-19) mRNA vaccination (BNT162b2). The deceased was a 76-year-old woman with diabetes mellitus (DM) and chronic hypertension (HTN), who experienced generalized pain for a month after the first dose of vaccination, and unexpectedly died. Postmortem examination revealed small vessel vasculitis in the heart, lungs and vaccinated site of the left arm. These features were similar to those observed in a previously reported case of a patient with COVID-19 and cardiac endotheliitis and multisystem inflammatory syndrome. In addition, DM and HTN may contribute to vaccine-induced immunologic changes and vascular dysfunction. However, further studies with additional cases are needed.

scholarly journals NCMP-23. PEMBROLIZUMAB-ASSOCIATED CD8+ VASCULITIC MONONEURITIS MULTIPLEX IN A PATIENT WITH MESOTHELIOMA: FIRST CASE REPORT

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii127-ii127
Author(s):  
Michaela Baldauf ◽  
Kapauer Monika ◽  
Jörger Markus ◽  
Flatz Lukas ◽  
Regulo Rodriguez ◽  
...  
Keyword(s):  
Case Report ◽  
Checkpoint Inhibitors ◽  
Axonal Neuropathy ◽  
Immunosuppressive Treatment ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
High Dose ◽  
Mononeuritis Multiplex ◽  
First Case ◽  
The Right

Abstract INTRODUCTION Immunotherapy, especially with immune checkpoint inhibitors (ICPI), has increasingly become an attractive treatment modality for various types of cancers. However, many patients develop ICPI-associated autoimmune adverse events such as pneumonitis, colitis or rarely neurological syndromes. Large and medium vessel vasculitis haS only occasionally been reported. Here we report the first case of ICPI-associated mononeuritis multiplex in a patient with malignant mesothelioma, caused by a histological proven small vessel vasculitis. CASE REPORT A 61-year old female developed subacute progressive painful and asymmetric sensorimotor deficits on distal extremities. Electrophysiologically, signs of a severe axonal neuropathy of both legs and the right arm were found, and swellings of the corresponding nerves were seen upon nerve ultrasound exam. The clinical and electrophysiological findings were reminiscent of mononeuritis multiplex. Laboratory work up including CSF examination was normal. More than two years prior to developing peripheral nerve deficits, the patient had been diagnosed with malignant pleural mesothelioma and treated with the anti-PD1 monoclonal antibody pembrolizumab on progression after chemotherapy. Biopsy of the right sural nerve revealed a small vessel vasculitis with a lymphocyte predominance of CD8+ T cells over CD4+ T as well as B lymphocytes. Despite discontinuation of pembrolizumab and immunosuppressive treatment (high dose methylprednisone, cyclophosphamide) complemented by opioid therapy, painful allodynia persisted. CONCLUSION ICPI-associated autoimmune disorders also include small vessel vasculitis with rare phenotypes such as mononeuritis multiplex. Further studies are required to improve our understanding of the link between ICPIs, and the pathogenic process leading to vasculitis, as well as to optimize treatment options for those rare diseases.

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