Chronic hand eczema understanding has ramifications on clinical management

2020 ◽  
Vol 34 (8) ◽  
Author(s):  
J.P. Thyssen ◽  
J.I. Silverberg ◽  
E. Guttman‐Yassky
Keyword(s):  
Clinical Management ◽  
Hand Eczema ◽  
Chronic Hand Eczema

Chronic hand eczema in Germany: 5-year follow-up data from the CARPE registry

2018 ◽  
Vol 80 (1) ◽  
pp. 45-53 ◽  
Author(s):  
Christian J. Apfelbacher ◽  
Robert F. Ofenloch ◽  
Elke Weisshaar ◽  
Sonja Molin ◽  
Andrea Bauer ◽  
...  
Keyword(s):  
Hand Eczema ◽  
Chronic Hand Eczema

scholarly journals Skin Microbiome in Patients with Hand Eczema and Healthy Controls: A Three-week Prospective Study

2021 ◽  
Author(s):  
Line Brok Nørreslet ◽  
Berit Lilje ◽  
Anna Cäcilia Ingham ◽  
Sofie Marie Edslev ◽  
Maja-Lisa Clausen ◽  
...  
Keyword(s):  
Prospective Study ◽  
Disease Severity ◽  
Amplicon Sequencing ◽  
Hand Eczema ◽  
Skin Microbiome ◽  
Healthy Controls ◽  
16S Rrna Amplicon Sequencing ◽  
Chronic Hand Eczema ◽  
Α Diversity ◽  
Underlying Mechanisms

The pathogenesis of chronic hand eczema remains unclear. Insights into the skin microbiome in hand eczema and its potential relevance to disease severity may help to elucidate the underlying mechanisms of hand eczema. The aim of this study was to characterize the microbiome in patients with hand eczema and healthy controls. A 5-visit prospective study was conducted over a period of 3 weeks. At each visit, bacterial swabs were taken from the hands of patients with hand eczema and controls. The microbiome was examined using DNA extraction and 16S rRNA amplicon sequencing (V3–V4 regions). Fifty patients with hand eczema and 50 controls were included (follow-up rate=100%). The baseline bacterial α-diversity was reduced on the hands of patients with hand eczema compared with controls (effect size=–0.31; 95% confidence interval (95% CI) –0.50; –0.11; p = 0.003). The dysbiosis on the patients’ hands was stable over the study period, was associated with disease severity, and was characterized by reduced bacterial diversity and different bacterial community compositions.

scholarly journals Drugs for the Treatment of Chronic Hand Eczema: Successes and Key Challenges [Corrigendum]

2021 ◽  
Vol Volume 17 ◽  
pp. 233-234
Author(s):  
Celina Dubin ◽  
Ester Del Duca ◽  
Emma Guttman-Yassky
Keyword(s):  
Hand Eczema ◽  
Chronic Hand Eczema

Chronic hand eczema and hepatogenic pruritus with good response to apremilast

2019 ◽  
Vol 32 (3) ◽  
Author(s):  
Francisco J. Navarro‐Triviño ◽  
Carlos Cuenca‐Barrales ◽  
Jorge J. Vega‐Castillo ◽  
Ricardo Ruiz‐Villaverde
Keyword(s):  
Hand Eczema ◽  
Chronic Hand Eczema
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