Usefulness of real‐time elastography for diagnosing lymph node metastasis of skin cancer: does elastography potentially eliminate the need for sentinel lymph node biopsy in squamous cell carcinoma?

2020 ◽  
Vol 34 (4) ◽  
pp. 754-761 ◽  
Author(s):  
T. Tanaka ◽  
M. Kamata ◽  
S. Fukaya ◽  
K. Hayashi ◽  
A. Fukuyasu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Skin Cancer ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Lymph Node Biopsy ◽  
Node Metastasis ◽  
Node Biopsy

Sentinel lymph node biopsy for clinically N0 oral squamous cell carcinoma.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 5584-5584
Author(s):  
Hiroyuki Goda ◽  
Koh-ichi Nakashiro ◽  
Ryota Oka ◽  
Satoru Shintani ◽  
Hiroyuki Hamakawa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Lymph Node Biopsy ◽  
Node Metastasis ◽  
Node Biopsy

5584 Background: Regionallymph node metastasis is an important prognostic factor in oral squamous cell carcinoma (OSCC). Sentinel lymph node biopsy (SLNB) is a widely accepted procedure in various human malignancies. In clinically N0 (cN0) OSCC cases, SLNB has received considerable attention for its role in deciding whether to perform neck dissection. In this study, we assessed the efficiency of SLNB for cN0 OSCC case in a single-institution experience. Methods: 100 patients with cN0 OSCC underwent SLNB between 2001 and 2011, of which 95 were clinically T1 and T2. The primary site was tongue, gingiva, oral floor, buccal mucosa, and lip in 50%, 36%, 8%, 5%, and 1%, respectively. The location of sentinel lymph node (SLN) was determined by radioisotope (RI) method with preoperative lymphoscintigraphy and intraoperative use of a handheld gamma probe and/or dye method, and evaluated by histopathological examination and genetic analysis. Results: SLNB was performed with RI and dye method (79%), only dye method (14%), or only RI method (7%). SLN was successfully identified with RI method (100%) and dye method (71%). The average number of SLN was 2.5 with dye method and 1.9 with RI method. The rate of SLN identified side was 84% in ipsilateral, 10% in bilateral, and 6% in contralateral. Fifteen of 100 patients (15%) had metastasis-positive SLN, and 3 patients was up-grade to stage III and others to stage IVA. Eight patients with negative SLN developed latent neck lymph node metastasis. The sensitivity, specificity, accuracy, and negative predictive value was 65% (15/23), 100% (77/77), 92% (92/100) and 91% (77/85). Disease specific survival rate for SLNB-negative patients were 98% (79/81), and for SLNB-positive patients were 73% (11/15), respectively. Conclusions: SLNB is a minimally invasive and highly reliable means of staging the cN0 neck for patients with OSCC. Patients with negative SLNB showed more excellent neck control rate and SLNB provides more accurate staging than elective neck dissection or wait and see.

Prospective evaluation of sentinel node navigation surgery in Japanese patients with low-risk endometrial cancer—safety and occurrence of lymphedema

2021 ◽  
Author(s):  
Hitoshi Niikura ◽  
Asami Toki ◽  
Tomoyuki Nagai ◽  
Satoshi Okamoto ◽  
Shogo Shigeta ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Lymph Node Metastasis ◽  
Lower Extremity ◽  
Lymph Node Biopsy ◽  
Occurrence Rate ◽  
Node Metastasis ◽  
Node Biopsy

Abstract Objective The present study aimed to clarify the occurrence rate of lymphedema and prognosis in patients with endometrial cancer according to sentinel lymph node biopsy alone with intraoperative histopathological examination. Methods The study included 45 consecutive patients with endometrial cancer treated at Tohoku University Hospital between October 2014 and August 2017. All patients had endometrial carcinoma with endometrioid histology Grade 1 or Grade 2 confirmed by biopsy and stage I on magnetic resonance imaging and/or computed tomography at their preoperative evaluation. Sentinel lymph node detection was performed by radioisotope and dye. Patients who were diagnosed intraoperatively as negative for sentinel lymph node metastasis did not undergo further systematic pelvic lymphadenectomy. The occurrence rate of lymphedema and prognosis was evaluated. Results Bilateral sentinel lymph nodes were detected in 44 of 45 patients (97%). Forty-three patients underwent sentinel lymph node biopsy alone, and only two patients underwent systematic lymphadenectomy. Sentinel lymph node metastases were detected in one patient intraoperatively and two patients postoperatively as ITCs. No patients experienced recurrence. New symptomatic lower-extremity lymphedema was identified in one of 43 patients (2.3%) who underwent sentinel lymph node biopsy alone. Conclusion Sentinel lymph node biopsy alone with intraoperative histopathological diagnosis appears to be a safe and effective strategy to detect lymph node metastasis and to reduce the number of patients with lower-extremity lymphedema among patients with endometrial cancer.

Validity of frozen section in sentinel lymph node biopsy for the staging in oral and oropharyngeal squamous cell carcinoma

2012 ◽  
Vol 106 (7) ◽  
pp. 816-819 ◽  
Author(s):  
Melanie S. Vorburger ◽  
Martina A. Broglie ◽  
Alex Soltermann ◽  
Stephan K. Haerle ◽  
Sarah R. Haile ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Frozen Section ◽  
Lymph Node Biopsy ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Node Biopsy

scholarly journals Rapid molecular detection of metastatic head and neck squamous cell carcinoma as an intraoperative adjunct to sentinel lymph node biopsy

2012 ◽  
Vol 122 (5) ◽  
pp. 1020-1030 ◽  
Author(s):  
Robert L. Ferris ◽  
Patrick Stefanika ◽  
Liqiang Xi ◽  
William Gooding ◽  
Raja R. Seethala ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Molecular Detection ◽  
Lymph Node Biopsy ◽  
Node Biopsy
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