Recurrence of conjunctival goblet cells after discontinuation of dupilumab in a patient with dupilumab‐related conjunctivitis

2019 ◽  
Vol 34 (2) ◽  
Author(s):  
A.N. Voorberg ◽  
W.F.A. den Dunnen ◽  
R.H.J. Wijdh ◽  
M.S. Bruin‐Weller ◽  
M.L.A. Schuttelaar
Keyword(s):  
Goblet Cells ◽  
Conjunctival Goblet Cells

OPC-12759 Increases Proliferation of Cultured Rat Conjunctival Goblet Cells

Cornea ◽  
2006 ◽  
Vol 25 (5) ◽  
pp. 573-581 ◽  
Author(s):  
José D. Ríos ◽  
Marie Shatos ◽  
Hiroki Urashima ◽  
Hao Tran ◽  
Darlene A. Dartt
Keyword(s):  
Goblet Cells ◽  
Conjunctival Goblet Cells

Morphological differentiation of the conjunctival goblet cells in the chick (Gallus domesticus)

1997 ◽  
Vol 235 (11) ◽  
pp. 717-722 ◽  
Author(s):  
Antonio Micali ◽  
Domenico Puzzolo ◽  
Alba M. Arco ◽  
Antonina Pisani ◽  
Giuseppe Santoro ◽  
...  
Keyword(s):  
Morphological Differentiation ◽  
Goblet Cells ◽  
Gallus Domesticus ◽  
Conjunctival Goblet Cells

scholarly journals How goblet cells respond to dry eye: adaptive and pathological roles of voltage-gated calcium channels and P2X7 purinoceptors

2020 ◽  
Vol 318 (6) ◽  
pp. C1305-C1315
Author(s):  
Donald G. Puro
Keyword(s):  
Calcium Channels ◽  
Dry Eye ◽  
Goblet Cell ◽  
Adaptive Strategy ◽  
Goblet Cells ◽  
High Gain ◽  
Cell Physiology ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Conjunctival Goblet Cells

Dry eye is a common sight-impairing, painful disorder characterized by disruption of the preocular tear film, whose integrity is required for ~70% of the eye’s refractive power. A universal feature of clinical dry eye is hyperosmolarity of the tears resulting from their accelerated evaporation due to dysfunction of tear- and oil-producing ocular glands. A key adaptive response to dryness/hyperosmolarity is release of tear-stabilizing mucin by conjunctival goblet cells. Yet the mechanisms mediating this response to hyperosmolarity remain poorly understood. In this study of freshly excised rat conjunctiva, perforated-patch recordings revealed that during sustained hyperosmolarity, the development of a nonspecific cation (NSC) conductance depolarizes the goblet cells to a near-optimal voltage for the tonic activation of their voltage-gated calcium channels (VGCCs). In turn, as demonstrated by high-resolution membrane capacitance measurements, VGCC activation boosts the exocytotic response of conjunctival goblet cells to neural input. However, over time, VGCC activation also increases the vulnerability of these cells to the lethality of hyperosmolarity. Viability assays further revealed that hyperosmotic-induced goblet cell death is critically dependent on P2X7 receptor channels. Similar to the yin-yang impact of VGCCs on goblet cell physiology and pathobiology, P2X7 activation not only compromises goblet cell viability but also enhances exocytotic activity. Thus, the NSC/VGCC and P2X7 purinoceptor pathways are components of a previously unappreciated high-gain/high-risk adaptive strategy to combat ocular dryness. These pathways boost release of tear-stabilizing mucin at the risk of jeopardizing the viability of the conjunctival goblet cells, whose loss is a histopathological hallmark of irreversible mucin-deficient dry eye.

Investigations on the conjunctival goblet cells and on the characteristics of glands associated with the eye in the guinea pig

2011 ◽  
Vol 14 (1) ◽  
pp. 26-40 ◽  
Author(s):  
Karin Gasser ◽  
Andrea Fuchs-Baumgartinger ◽  
Alexander Tichy ◽  
Barbara Nell
Keyword(s):  
Guinea Pig ◽  
Goblet Cells ◽  
Conjunctival Goblet Cells

Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells

2008 ◽  
Vol 86 (4) ◽  
pp. 629-636 ◽  
Author(s):  
J. David Ríos ◽  
Marie A. Shatos ◽  
Hiroki Urashima ◽  
Darlene A. Dartt
Keyword(s):  
Egf Receptor ◽  
Goblet Cells ◽  
Receptor Activation ◽  
Mapk Activity ◽  
Conjunctival Goblet Cells
Sign in / Sign up

Export Citation Format

Share Document