Remodelling of calcinosis cutis in a patient with scleroderma overlap syndrome

2019 ◽  
Vol 34 (1) ◽  
Author(s):  
M.R. Dittmer ◽  
M. Ogawa‐Momohara ◽  
Y. Muro ◽  
M. Kono ◽  
M. Akiyama
Keyword(s):  
Overlap Syndrome ◽  
Calcinosis Cutis

scholarly journals Resolution of calcinosis using bisphosphonates in overlap syndrome – a case report

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Mitchell Platter ◽  
Brian Pugmire ◽  
Reshma Patel
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Soft Tissue ◽  
Ct Scan ◽  
Successful Treatment ◽  
Lupus Erythematosus ◽  
Complete Resolution ◽  
Juvenile Dermatomyositis ◽  
Overlap Syndrome ◽  
Systemic Lupus ◽  
Calcinosis Cutis

Abstract Introduction Calcinosis cutis is a common complication of pediatric rheumatologic diseases. However, there is currently no consensus on first-line treatment. Bisphosphonates have been described as a successful treatment in several case studies, but most of these cases are limited to patients with isolated juvenile dermatomyositis or systemic sclerosis. Specifically, there are limited reports of their usefulness in treating overlap syndromes and mixed connective tissue disorders. Case presentation We describe the case of a 13 year-old girl with overlap syndrome with features of juvenile dermatomyositis and systemic lupus erythematosus. After 22 months of extensive immunosuppressive therapy, including monthly IVIG and Rituximab, she continued to have pain and weakness of the lower extremities. A CT scan was performed which showed significant multifocal soft tissue calcifications of the pelvis. She was started on treatment with oral alendronate with the goal of improving her calcinosis and improving her symptoms. After several months of therapy, our patient reported subjective improvement of her lower extremity pain and weakness, as well as complete resolution of abnormalities previously seen on physical examination. A repeat CT scan of the pelvis was performed after 11 months of therapy and demonstrated complete resolution of the previously seen calcinosis. Conclusions We report the successful treatment of soft tissue calcinosis with oral bisphosphonates in a patient with juvenile dermatomyositis-systemic lupus erythematosus overlap syndrome. These results provide further evidence that bisphosphonates can be used successfully to treat calcinosis cutis in pediatric rheumatologic disorders. Additionally, the results provide new evidence that they can be used specifically in juvenile dermatomyositis-systemic lupus erythematosus overlap syndrome, which has not been previously reported.

Calcinosis cutis universalis secondary to scleroderma-polymyositis overlap syndrome

2021 ◽  
Author(s):  
Matthew Colquhoun ◽  
Hassan Hirji ◽  
Adriana Martinez ◽  
Shahir Hamdulay
Keyword(s):  
Overlap Syndrome ◽  
Calcinosis Cutis

Resolution of Calcinosis using Bisphosphonates in Overlap Syndrome – A Case Report

2020 ◽  
Author(s):  
Mitchell Platter ◽  
Brian Pugmire ◽  
Reshma Patel
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Soft Tissue ◽  
Ct Scan ◽  
Successful Treatment ◽  
Lupus Erythematosus ◽  
Complete Resolution ◽  
Juvenile Dermatomyositis ◽  
Overlap Syndrome ◽  
Systemic Lupus ◽  
Calcinosis Cutis

Abstract Background Calcinosis cutis is a common complication of pediatric rheumatologic diseases. However, there is currently no consensus on first-line treatment. Bisphosphonates have been described as successful treatment in several case studies, but most of these cases are limited to patients with isolated juvenile dermatomyositis or systemic sclerosis. Specifically, there are limited reports of their usefulness in treating overlap syndromes and mixed connective tissue disorders.Case Presentation: We describe the case of a 13 year-old girl with overlap syndrome with mostly features of juvenile dermatomyositis and systemic lupus erythematosus. After 22 months of extensive immunosuppressive therapy, including monthly IVIG, she continued to have pain and weakness of the lower extremities. A CT scan was performed which showed significant multifocal soft tissue calcifications of the pelvis. She was started on treatment with oral alendronate with the goal of improving her calcinosis and improving her symptoms. After several months of therapy, our patient reported subjective improvement of her lower extremity pain and weakness, as well as complete resolution of abnormalities previously seen on physical examination. A repeat CT scan of the pelvis was performed after 11 months of therapy and demonstrated complete resolution of the previously seen calcinosis.Conclusions We report the successful treatment of soft tissue calcinosis with oral bisphosphonates in a patient with juvenile dermatomyositis-systemic lupus erythematosus overlap syndrome. These results provide further evidence that bisphosphonates can be used successfully to treat calcinosis cutis in pediatric rheumatologic disorders. Additionally, the results provide new evidence that they can be used specifically in juvenile dermatomyositis-systemic lupus erythematosus overlap syndrome, which has not been previously reported.

A Case of Milia-like Idiopathic Calcinosis Cutis in Down Syndrome

2008 ◽  
Vol 70 (6) ◽  
pp. 621-624
Author(s):  
Yoshio ITO ◽  
Tetsuo SASAKI ◽  
Yoshiko YATA ◽  
Junko KAWASHIMA ◽  
Shinichi TAKAHASHI
Keyword(s):  
Down Syndrome ◽  
Calcinosis Cutis

Milia-like Idiopathic Calcinosis Cutis in Down Syndrome.

2000 ◽  
Vol 62 (4) ◽  
pp. 466-468 ◽  
Author(s):  
Yoshihiro UMEBAYASHI ◽  
Shusaku ITO ◽  
Ken NAGAYAMA
Keyword(s):  
Down Syndrome ◽  
Calcinosis Cutis
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