Successful treatment of co‐existent SAPHO syndrome and hidradenitis suppurativa with adalimumab and methotrexate

2019 ◽  
Vol 33 (S6) ◽  
pp. 40-41 ◽  
Author(s):  
G. Genovese ◽  
R. Caorsi ◽  
C. Moltrasio ◽  
A.V. Marzano
Keyword(s):  
Successful Treatment ◽  
Hidradenitis Suppurativa ◽  
Sapho Syndrome

Successful treatment of Sapho syndrome and hidradenitis suppurativa: A therapeutic challenge

2020 ◽  
Vol 33 (3) ◽  
Author(s):  
Luca Fania ◽  
Francesco Moro ◽  
Antonio Clemente ◽  
Donatella Sordi ◽  
Alessandra Scarabello ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Hidradenitis Suppurativa ◽  
Sapho Syndrome ◽  
Therapeutic Challenge

scholarly journals Successful Treatment of Recalcitrant Hidradenitis Suppurativa with Adalimumab

2009 ◽  
Vol 1 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Ian Gorovoy ◽  
Adar Berghoff ◽  
Laura Ferris
Keyword(s):  
Successful Treatment ◽  
Hidradenitis Suppurativa

A Case of Successful Treatment of Refractory Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome with Adalimumab

2013 ◽  
Vol 30 (1) ◽  
pp. 55
Author(s):  
Jin Taek Yoo ◽  
Young Hwan Kim ◽  
Soon Myung Jung ◽  
Sang Chang Kwon ◽  
Seung Min Ryu ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Sapho Syndrome

scholarly journals Successful treatment of SAPHO syndrome with zoledronic acid

2004 ◽  
Vol 50 (9) ◽  
pp. 2970-2973 ◽  
Author(s):  
Petros Kopterides ◽  
Dimitrios Pikazis ◽  
Christos Koufos
Keyword(s):  
Zoledronic Acid ◽  
Successful Treatment ◽  
Sapho Syndrome

scholarly journals Surgical treatment of chronic hidradenitis suppurativa in the gluteal and perianal regions

2012 ◽  
Vol 59 (2) ◽  
pp. 91-95 ◽  
Author(s):  
Sokol Bilali ◽  
Vangjel Todi ◽  
Ali Lila ◽  
Valbona Bilali ◽  
Julian Habibaj
Keyword(s):  
Wound Healing ◽  
Successful Treatment ◽  
Hidradenitis Suppurativa ◽  
Surgical Excision ◽  
Healing Time ◽  
Complete Healing ◽  
Sweat Glands ◽  
Apocrine Glands ◽  
Treatment Methods ◽  
Complete Wound Healing

Introduction: Verneuil disease, or perianal hidradenitis suppurativa (HS), is a chronic suppurative disease with a tendency to develop sinus formation, fibrosis, and sclerosis, having a great impact on quality of life. HS affect the apocrine sweat glands or sebaceous glands and may arise in each of the regions where the apocrine glands are prominent: the axilla, breast aureole, umbilicus, perineum, groin, and buttocks. We present here moderate and extensive HS cases, with their respective treatment methods and outcomes. Methods: A retrospective re-view of 6 patients? medical records from January 2001 to December 2010. Results: The 6 patients underwent treatment for HS in the gluteal and perianal regions with surgical excision. Five of the patients were male (83%). The median age was 42.5 years. We performed a total of 8 operations on these patients. In 3 patients, the wound was left open for secondary healing, and the mean time for complete wound healing was 11.3 weeks (range: 9.5-19 weeks). Delayed skin grafting was used for 2 patients in whom the wounds had been left open after the first operation. In this group, complete wound healing took 2 months in total. One patient underwent primary wound closure using rotation flaps, with a complete healing time of 2 weeks. Successful treatment without recurrence was accomplished in 5 (83.3%) of the patients. Conclusion: The conservative treatment methods had little effect, particularly on gluteal and perianal/perineal HS. The only successful treatment was wide surgical excision. Management of the wound after wide excision should be tailored to the individual patient.

Efficacy of Adalimumab on Severe Sapho Syndrome Likely Triggered by Isotretinoin

2020 ◽  
Author(s):  
Michele Luzzati ◽  
Cesare Filippeschi ◽  
Teresa Giani ◽  
Sandra Trapani
Keyword(s):  
Hidradenitis Suppurativa ◽  
Severe Depression ◽  
Joint Inflammation ◽  
Sapho Syndrome ◽  
Adolescent Male ◽  
Clinical Feature ◽  
Severe Acne ◽  
Chronic Disorder ◽  
Tnf Α ◽  
Acne Fulminans

Abstract Background SAPHO (synovitis, acne, pustolosis, hyperostosis and osteitis) syndrome is a rare autoinflammatory chronic disorder, presenting with non-infectious inflammatory osteitis, sterile joint inflammation and skin manifestations including palmoplantar pustolosis and severe acne. It could be often misdiagnosed for its heterogeneous clinical presentation. Isotretinoin, which is commonly used for severe acne treatment, has been rarely described as possible trigger of osteo-articular manifestations, in particular sacroiliitis. Various biological treatment have been proposed in refractory patients.Case presentation The case of an adolescent male, affected by acne fulminans and depression, who presented with sacroiliitis after a 10-week treatment with isotretinoin is presented and discussed. After SAPHO diagnosis, the boy started NSAIDs therapy but the onset of bilateral gluteal hidradenitis suppurativa required the switch to a tumour necrosis factor (TNF)-α antagonist (adalimumab). Despite specific therapy with sertraline, the patient continued to complain severe depression, this symptom has been widely reported in patient with SAPHO.Conclusions Our case strengthens the hypothesis that isotretinoin could be a trigger of musculoskeletal involvement in SAPHO. The occurrence of hidradenitis suppurativa as additional clinical feature of SAPHO, already described in literature, supported the TNF-α blocker’s commencement in our patient. Furthermore, the good outcome of our case confirms the efficacy of ADA treatment in obtaining persistent clinical remission of cutaneous and osteoarticular symptoms in SAPHO syndrome.

scholarly journals Successful treatment of resistant SAPHO syndrome with anti-TNF therapy

2013 ◽  
Vol 2013 (jan25 1) ◽  
pp. bcr2012007161-bcr2012007161 ◽  
Author(s):  
S. L. Hampton ◽  
H. Youssef
Keyword(s):  
Successful Treatment ◽  
Sapho Syndrome
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