Gamma‐delta T cell large granular lymphocyte leukaemia with multiple cutaneous nodules that showed spontaneous regression

2018 ◽  
Vol 33 (3) ◽  
Author(s):  
C. Suzuki ◽  
I. Hirai ◽  
H. Nomura ◽  
T. Ouchi ◽  
M. Okayama ◽  
...  
Keyword(s):  
T Cell ◽  
Spontaneous Regression ◽  
Large Granular Lymphocyte ◽  
Gamma Delta ◽  
Large Granular Lymphocyte Leukaemia ◽  
Gamma Delta T Cell

scholarly journals Gamma delta T-cell large granular lymphocyte lymphoma in a dog

2015 ◽  
Vol 44 (3) ◽  
pp. 442-447 ◽  
Author(s):  
Ana Liza Ortiz ◽  
Sofia Carvalho ◽  
Chiara Leo ◽  
Fulvio Riondato ◽  
Joy Archer ◽  
...  
Keyword(s):  
T Cell ◽  
Large Granular Lymphocyte ◽  
Gamma Delta ◽  
Gamma Delta T Cell

scholarly journals Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes.

1988 ◽  
Vol 168 (5) ◽  
pp. 1899-1916 ◽  
Author(s):  
J A Bluestone ◽  
R Q Cron ◽  
M Cotterman ◽  
B A Houlden ◽  
L A Matis
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Line ◽  
Gene Segment ◽  
Cell Receptor ◽  
Gamma Delta ◽  
Human T Cells ◽  
T Cell Lines ◽  
Gamma Delta T Cell ◽  
Delta Cells

Analyses of TCR-bearing murine and human T cells have defined a unique subpopulation of T cells that express the TCR-gamma/delta proteins. The specificity of TCR-gamma/delta T cells and their role in the immune response have not yet been elucidated. Here we examine alloreactive TCR-gamma/delta T cell lines and clones that recognize MHC-encoded antigens. A BALB/c nu/nu (H-2d)-derived H-2k specific T cell line and derived clones were both cytolytic and released lymphokines after recognition of a non-classical H-2 antigen encoded in the TL region of the MHC. These cells expressed the V gamma 2/C gamma 1 protein in association with a TCR-delta gene product encoded by a Va gene segment rearranged to two D delta and one J delta variable elements. A second MHC-specific B10 nu/nu (H-2b) TCR-gamma/delta T cell line appeared to recognize a classical H-2D-encoded MHC molecule and expressed a distinct V gamma/C gamma 4-encoded protein. These data suggest that many TCR-gamma/delta-expressing T cells may recognize MHC-linked antigens encoded within distinct subregions of the MHC. The role of MHC-specific TCR-gamma/delta cells in immune responses and their immunological significance are discussed.

An Unusual Case of a Splenic Gamma/Delta T-cell Lymphoma with Angiocentric Tendency and Haemophagocytic Syndrome

1996 ◽  
Vol 23 (5-6) ◽  
pp. 631-634 ◽  
Author(s):  
August Zabernigg ◽  
Falko Fend ◽  
Josef Thaler ◽  
Claus Gattringer
Keyword(s):  
T Cell ◽  
Unusual Case ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Gamma Delta ◽  
Haemophagocytic Syndrome ◽  
Gamma Delta T Cell

scholarly journals Gamma-delta t-cell lymphomas

2014 ◽  
Vol 94 (3) ◽  
pp. 206-218 ◽  
Author(s):  
Marco Foppoli ◽  
Andrés J. M. Ferreri
Keyword(s):  
T Cell ◽  
Gamma Delta ◽  
T Cell Lymphomas ◽  
Gamma Delta T Cell

scholarly journals Different gamma delta T-cell receptors are expressed on thymocytes at different stages of development.

1989 ◽  
Vol 86 (2) ◽  
pp. 631-635 ◽  
Author(s):  
K. Ito ◽  
M. Bonneville ◽  
Y. Takagaki ◽  
N. Nakanishi ◽  
O. Kanagawa ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Gamma Delta ◽  
Stages Of Development ◽  
Cell Receptors ◽  
Gamma Delta T Cell

Gamma-delta T-cell lymphomas

2009 ◽  
Vol 6 (12) ◽  
pp. 707-717 ◽  
Author(s):  
Claudio Tripodo ◽  
Emilio Iannitto ◽  
Ada Maria Florena ◽  
Carlo Ennio Pucillo ◽  
Pier Paolo Piccaluga ◽  
...  
Keyword(s):  
T Cell ◽  
Gamma Delta ◽  
T Cell Lymphomas ◽  
Gamma Delta T Cell

scholarly journals Hepatosplenic T-cell lymphoma: a distinct clinicopathologic entity of cytotoxic gamma delta T-cell origin

Blood ◽  
1996 ◽  
Vol 88 (11) ◽  
pp. 4265-4274 ◽  
Author(s):  
CB Cooke ◽  
L Krenacs ◽  
M Stetler-Stevenson ◽  
TC Greiner ◽  
M Raffeld ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Killer Cell ◽  
Clinical Manifestations ◽  
Lymphoid Cells ◽  
T Cell Lymphoma ◽  
Survival Duration ◽  
Adult Males ◽  
Gamma Delta ◽  
Gamma Delta T Cell

We identified eight cases of T-cell lymphoma with evidence of a gamma delta phenotype over a 13-year period. Seven of these cases conformed to a distinct clinicopathologic entity of hepatosplenic gamma delta T- cell lymphoma. Nearly all of these patients were young adult males (five of seven), with a median age at presentation of 20 years. They presented with marked hepatosplenomegaly, without lymphadenopathy or significant peripheral blood lymphocytosis. Thrombocytopenia was seen in all patients, and five of seven were mildly anemic. The clinical course was aggressive, and despite multiagent chemotherapy, the median survival duration was less than 1 year. The morphologic findings were uniform; a monomorphic population of medium-sized lymphoid cells with moderately clumped chromatin and a rim of pale cytoplasm infiltrated the sinusoids of the spleen, liver, and bone marrow. The cells had a characteristic immunophenotype: CD2+, CD3+, CD4-, CD5-, CD7+, CD16+, CD57-, CD25-, T-cell receptor (TCR)delta +, beta F1-. CD8 was positive in four of seven cases tested, and CD56 was positive in five of six. All cases expressed the cytotoxic granule-associated protein, TIA1, but perforin was detected in only one case. All cases with assessable DNA had a TCR gamma gene rearrangement, and lacked Epstein-Barr virus sequences. Isochromosome 7q was identified in two cases with cytogenetic information. The one case of cutaneous gamma delta T-cell lymphoma differed in its clinical manifestations, histologic appearance, and immunophenotype. We conclude that hepatosplenic gamma delta T-cell lymphoma is a distinct clinicopathologic entity derived from cytotoxic gamma delta T cells, and should be distinguished from other lymphomas of T-cell and natural-killer cell (NK)-like T-cell derivation.

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