Chronology of regional lymph node metastases in cutaneous melanoma: a model based on mitotic rate

2018 ◽  
Vol 32 (7) ◽  
pp. e289-e291
Author(s):  
A. Tejera-Vaquerizo ◽  
J. J. Meléndez ◽  
E. Nagore
1984 ◽  
Vol 12 (4) ◽  
pp. 260-263 ◽  
Author(s):  
Eliot M. Rosen ◽  
J. Robert Cassady ◽  
Cynthia Kretschmar ◽  
Christopher N. Frantz ◽  
Stephen E. Sallan ◽  
...  

2016 ◽  
Vol 41 (4) ◽  
pp. e181-e186 ◽  
Author(s):  
Suzana Cipriano Teixeira ◽  
Bas B. Koolen ◽  
Wouter V. Vogel ◽  
Jelle Wesseling ◽  
Marcel P. M. Stokkel ◽  
...  

2005 ◽  
Vol 32 (8) ◽  
pp. 925-931 ◽  
Author(s):  
Rimma Danielsson ◽  
Margaretha Bååth ◽  
Leif Svensson ◽  
Ulrica Forslöv ◽  
Karl-Gustav Kölbeck

2021 ◽  
Author(s):  
Arash Golpazir ◽  
Mehri Nazeri ◽  
Seyed mostafa meshkati yazd ◽  
Mohamadreza Karoobi ◽  
Houshang Nemati ◽  
...  

Abstract Background: Cutaneous Melanoma (CM) is cancer with rising prevalence worldwide. The most significant predictor of CM is regional lymph node metastasis. Sentinel Lymph Node (SLN) biopsy has been used to stage CM and to identify lymphatic metastasis. This study aims to evaluate the SLN association with clinicopathological factors in the CM patients for a better surgical management. Methods: This retrospective study included 80 CM patients who had gone through lymphatic mapping and SLN biopsy at Imam Khomeini Hospital in Tehran from 2011 to 2018. The clinical and histologic factors, including sex, age, tumor location, Breslow thickness, ulceration, angiolymphatic invasion, tumor mitotic rate (TMR), and Clark level, were analyzed.Results: Fifty-six patients (70%) were found to have SLN, 19 patients (33.9%) were SLN-positive, and 37 patients (66.1%) were SLN-negative. Breslow thickness was the only variable that was significantly associated with the prediction of SLN. SLN was not correlated with other features such as ulceration, angiolymphatic invasion, and tumor mitotic rate. Complete Lymph Node Dissection (CLND) was carried out in 18 out of 19 SLN-positive patients. Moreover, 5 patients (27.8%) were found to be non-SLN-positive out of 18 SLN biopsy+CLND-positive patients. Furthermore, there was not any significant relationship between the clinicopathological features and the prediction of non-SLN. Conclusions: Breslow thickness was significantly correlated with positive SLN biopsy. Thus, it can be a strong predictor of positive SLN in CM patients.


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